New microfluidic paths to test for bleeding or clotting
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These microfluidic devices have an endothelialized lumen that can reliably capture features of blood vessels such as atherosclerotic plaque deposition and bifurcations by altering channel geometry and flow patterns.
“These devices possess endothelialized lumen that can reliably capture several features of blood vessels such as atherosclerosis (i.e. fatty plaque deposition and formation) and bifurcations (i.e. branches and bends) by changing the channel geometries and flow patterns, ranging from laminar steady flow to pulsatile flow [287–290,295–304].”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [299]
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Cites
Fluid Mechanics of Blood Clot Formation
Fogelson, A. L., & Neeves, K. B. (2014) · Annual Review of Fluid Mechanics · doi:10.1146/annurev-fluid-010814-014513 · Cited by 305 · see citing works
Neeves, K. B., Maloney, S. F., Fong, K. P., Schmaier, A. A., Kahn, M. L., Brass, L. F., & Diamond, S. L. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03188.x · Cited by 151 · see citing works
Self-citationMicrofluidics and Coagulation Biology
Colace, T. V., Tormoen, G. W., McCarty, O. J. T., & Diamond, S. L. (2013) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071812-152406 · Cited by 126 · see citing works
Self-citationTransport physics and biorheology in the setting of hemostasis and thrombosis
Brass, L. F., & Diamond, S. L. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13280 · Cited by 94 · see citing works
Self-citationA Microfluidic Model of Hemostasis Sensitive to Platelet Function and Coagulation
Schoeman, R. M., Rana, K., Danes, N., Lehmann, M., Paola, J. A. D., Fogelson, A. L., Leiderman, K., & Neeves, K. B. (2016) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-016-0469-0 · Cited by 58 · see citing works
Dynamics of Blood Flow and Thrombus Formation in a Multi-Bypass Microfluidic Ladder Network
Zilberman‐Rudenko, J., Sylman, J. L., Lakshmanan, H. H. S., McCarty, O. J. T., & Maddala, J. (2016) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-016-0470-7 · Cited by 46 · see citing works
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Cardiovascular disease models: A game changing paradigm in drug discovery and screening
Savoji, H., Mohammadi, M. H., Rafatian, N., Toroghi, M. K., Wang, E. Y., Zhao, Y., Korolj, A., Ahadian, S., & Radisic, M. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.036 · Cited by 223 · see citing works
- Authors
- Diamond, S. L.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Diamond, Scott L.
- ORCID
- Diamond, Scott L.
- Venue
- Cellular and Molecular Bioengineering
- Published
- 2017-01-18
- Volume
- 10
- Issue
- 1
- Pages
- 1-2
- ISSN
- 1865-5025 (ISSN-L)
- 1865-5033
- PMC
- PMC5600493
- OpenAlex
- W2574187080
- Cited by
- 9
- References
- 6
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 4
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cellular and Molecular Bioengineering (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (U01HL131053, R01HL103419)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- microfluidics, hemorrhage, coagulation, clotting, hemostasis, coagulation tests
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