Cited by 42Drug-Induced Hepatotoxicity and ProtectionMedicinal plant effects and applicationsMedicinal Plant Research

Eleusine indica L. possesses antioxidant activity and precludes carbon tetrachloride (CCl4)-mediated oxidative hepatic damage in rats

Open access
Iqbal, Mohammad, Gnanaraj, Charles·2012·Environmental Health and Preventive Medicine

Abstract

OBJECTIVES: The purpose of this study was to evaluate the ability of aqueous extract of Eleusine indica to protect against carbon tetrachloride (CCl₄)-induced hepatic injury in rats. METHODS: The antioxidant activity of E. indica was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. The total phenolic content of E. indica was also determined. Biochemical parameters [e.g. alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), glutathione (GSH), catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase and quinone reductase] were used to evaluate hepatic damage in animals pretreated with E. indica and intoxicated with CCl₄. CCl₄-mediated hepatic damage was also evaluated by histopathologically. RESULTS: E. indica extract was able to reduce the stable DPPH level in a dose-dependent manner. The half maximal inhibitory concentration (IC₅₀) value was 2350 μg/ml. Total phenolic content was found to be 14.9 ± 0.002 mg/g total phenolic expressed as gallic acid equivalent per gram of extract. Groups pretreated with E. indica showed significantly increased activity of antioxidant enzymes compared to the CCl₄-intoxicated group (p < 0.05). The increased levels of serum ALT and AST were significantly prevented by E. indica pretreatment (p < 0.05). The extent of MDA formation due to lipid peroxidation was significantly reduced (p < 0.05), and reduced GSH was significantly increased in a dose-dependently manner (p < 0.05) in the E. indica-pretreated groups as compared to the CCl₄-intoxicated group. The protective effect of E. indica was further evident through decreased histopathological alterations in the liver. CONCLUSION: The results of our study indicate that the hepatoprotective effects of E. indica might be ascribable to its antioxidant and free radical scavenging property.

Integrity signals

Registry

Crossref · 10.1007/s12199-011-0255-5

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 41 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Iqbal, M., & Gnanaraj, C.
Affiliations
Universiti of Malaysia Sabah (MY)
Corresponding author
Iqbal, Mohammad
Venue
Environmental Health and Preventive Medicine
Published
2011-12-30
Volume
17
Issue
4
Pages
307-315
ISSN
  • 1342-078X (ISSN-L)
  • 1347-4715
OpenAlex
W1977314068
Cited by
42
References
41
Citations by year
2026: 3 · 2025: 1 · 2024: 9 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 3 · 2012: 1
FWCI
1.35
Type
journal article
Language
en
Open access
Locations
  • Environmental Health and Preventive Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Universiti Malaysia Sabah
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal plant effects and applications
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
Eleusine indica, carbon tetrachloride, hepatotoxicity, hepatoprotection, antioxidant activity, free radical scavenging, oxidative liver damage, lipid peroxidation, antioxidant enzymes, glutathione, total phenolic content, aqueous plant extract
MeSH terms
Animals, Antioxidants, Carbon Tetrachloride Poisoning, Disease Models, Animal, Male, Plant Extracts, Rats, Sprague-Dawley, Oxidative Stress, Eleusine, Rats, Chemical and Drug Induced Liver Injury

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review