Eleusine indica L. possesses antioxidant activity and precludes carbon tetrachloride (CCl4)-mediated oxidative hepatic damage in rats
Open accessAbstract
OBJECTIVES: The purpose of this study was to evaluate the ability of aqueous extract of Eleusine indica to protect against carbon tetrachloride (CCl₄)-induced hepatic injury in rats. METHODS: The antioxidant activity of E. indica was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. The total phenolic content of E. indica was also determined. Biochemical parameters [e.g. alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), glutathione (GSH), catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase and quinone reductase] were used to evaluate hepatic damage in animals pretreated with E. indica and intoxicated with CCl₄. CCl₄-mediated hepatic damage was also evaluated by histopathologically. RESULTS: E. indica extract was able to reduce the stable DPPH level in a dose-dependent manner. The half maximal inhibitory concentration (IC₅₀) value was 2350 μg/ml. Total phenolic content was found to be 14.9 ± 0.002 mg/g total phenolic expressed as gallic acid equivalent per gram of extract. Groups pretreated with E. indica showed significantly increased activity of antioxidant enzymes compared to the CCl₄-intoxicated group (p < 0.05). The increased levels of serum ALT and AST were significantly prevented by E. indica pretreatment (p < 0.05). The extent of MDA formation due to lipid peroxidation was significantly reduced (p < 0.05), and reduced GSH was significantly increased in a dose-dependently manner (p < 0.05) in the E. indica-pretreated groups as compared to the CCl₄-intoxicated group. The protective effect of E. indica was further evident through decreased histopathological alterations in the liver. CONCLUSION: The results of our study indicate that the hepatoprotective effects of E. indica might be ascribable to its antioxidant and free radical scavenging property.
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Eleusine indica has antioxidant properties.
“The scientific data collected show that Eleusine indica has antidiabetic, antimalarial, antibacterial, antifungal, anti-trypanosomal, antihelmintic, antioxidant, anti-inflammatory, antiurolithiasic, antiviral, phytoremediating, hepatoprotective and phytoremediating properties.”
From Review of the literature of Eleusine indica: phytochemical, toxicity, pharmacological and zootechnical studies (2021) · cites this paper as [9]
Eleusine indica has hepatoprotective properties.
“The scientific data collected show that Eleusine indica has antidiabetic, antimalarial, antibacterial, antifungal, anti-trypanosomal, antihelmintic, antioxidant, anti-inflammatory, antiurolithiasic, antiviral, phytoremediating, hepatoprotective and phytoremediating properties.”
From Review of the literature of Eleusine indica: phytochemical, toxicity, pharmacological and zootechnical studies (2021) · cites this paper as [9]
Paragis has antioxidant activity.
“antioxidant activity (Al-Zubairi et al., 2011;Iqbal & Gnanaraj, 2012)”
From Utilization of Unwanted Weed, Paragis Leaves (Eleusine indica Linn.) in Cookie Production (2020) · cites this paper as Iqbal & Gnanaraj, 2012
The pharmaceutical action of E. indica is due to its generous supply of phytochemicals and antioxidants.
“The hepaprotective effect (Iqbal & Gnanaraj, 2012) and pharmaceutical action of E. indica were reported to have been due to the generous supply of phytochemicals and antioxidants.”
From Utilization of Unwanted Weed, Paragis Leaves (Eleusine indica Linn.) in Cookie Production (2020) · cites this paper as Iqbal & Gnanaraj, 2012
Paragis has a hepatoprotective effect.
“The hepaprotective effect (Iqbal & Gnanaraj, 2012)”
From Utilization of Unwanted Weed, Paragis Leaves (Eleusine indica Linn.) in Cookie Production (2020) · cites this paper as Iqbal & Gnanaraj, 2012
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- Authors
- Iqbal, M., & Gnanaraj, C.
- Affiliations
- Universiti of Malaysia Sabah (MY)
- Corresponding author
- Iqbal, Mohammad
- Venue
- Environmental Health and Preventive Medicine
- Published
- 2011-12-30
- Volume
- 17
- Issue
- 4
- Pages
- 307-315
- ISSN
- 1342-078X (ISSN-L)
- 1347-4715
- PMC
- PMC3390565
- OpenAlex
- W1977314068
- Cited by
- 42
- References
- 41
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 9 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 3 · 2012: 1
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Environmental Health and Preventive Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universiti Malaysia Sabah
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal plant effects and applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Eleusine indica, carbon tetrachloride, hepatotoxicity, hepatoprotection, antioxidant activity, free radical scavenging, oxidative liver damage, lipid peroxidation, antioxidant enzymes, glutathione, total phenolic content, aqueous plant extract
- MeSH terms
- Animals, Antioxidants, Carbon Tetrachloride Poisoning, Disease Models, Animal, Male, Plant Extracts, Rats, Sprague-Dawley, Oxidative Stress, Eleusine, Rats, Chemical and Drug Induced Liver Injury
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