Cited by 157Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressNitric Oxide and Endothelin Effects

Role of oxidative stress in infectious diseases. A review

Pohanka, Miroslav·2013·Folia Microbiologica

Abstract

Oxidative stress plays a dual role in infections. Free radicals protect against invading microorganisms, and they can also cause tissue damage during the resulting inflammation. In the process of infection, there is generation of reactive species by myeloperoxidase, NADPH oxidase, and nitric oxide synthase. On the other hand, reactive species can be generated among others, by cytochrome P450, some metals, and xanthine oxidase. Some pathologies arising during infection can be attributed to oxidative stress and generation of reactive species in infection can even have fatal consequences. This article reviews the basic pathways in which reactive species can accumulate during infectious diseases and discusses the related health consequences.

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Crossref · 10.1007/s12223-013-0239-5

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Authors
Pohanka, M.
Affiliations
University of Defence (CZ)
Corresponding author
Pohanka, Miroslav
Venue
Folia Microbiologica
Published
2013-03-17
Volume
58
Issue
6
Pages
503-513
ISSN
  • 0015-5632 (ISSN-L)
  • 1874-9356
OpenAlex
W2086679562
Cited by
157
References
127
Citations by year
2026: 6 · 2025: 13 · 2024: 9 · 2023: 12 · 2022: 17 · 2021: 29 · 2020: 15 · 2019: 9 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 7 · 2014: 7 · 2013: 3 · 2012: 1
FWCI
5.12
Type
journal article
Language
en
Open access
closed
Locations
  • Folia Microbiologica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
oxidative stress, infectious diseases, reactive oxygen species, free radicals, myeloperoxidase, NADPH oxidase, nitric oxide synthase, cytochrome P450, xanthine oxidase, inflammation, tissue damage, host defense
MeSH terms
Communicable Diseases, Cytochrome P-450 Enzyme System, Free Radicals, Humans, Metals, Peroxidase, Xanthine Oxidase, Oxidative Stress, Nitric Oxide Synthase, NADPH Oxidases, Metabolic Networks and Pathways

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