Role of oxidative stress in infectious diseases. A review
Abstract
Oxidative stress plays a dual role in infections. Free radicals protect against invading microorganisms, and they can also cause tissue damage during the resulting inflammation. In the process of infection, there is generation of reactive species by myeloperoxidase, NADPH oxidase, and nitric oxide synthase. On the other hand, reactive species can be generated among others, by cytochrome P450, some metals, and xanthine oxidase. Some pathologies arising during infection can be attributed to oxidative stress and generation of reactive species in infection can even have fatal consequences. This article reviews the basic pathways in which reactive species can accumulate during infectious diseases and discusses the related health consequences.
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Flagged first, then by citations
Cited by
Sorted by citations
- Authors
- Pohanka, M.
- Affiliations
- University of Defence (CZ)
- Corresponding author
- Pohanka, Miroslav
- ORCID
- Pohanka, Miroslav
- Venue
- Folia Microbiologica
- Published
- 2013-03-17
- Volume
- 58
- Issue
- 6
- Pages
- 503-513
- ISSN
- 0015-5632 (ISSN-L)
- 1874-9356
- OpenAlex
- W2086679562
- Cited by
- 157
- References
- 127
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 9 · 2023: 12 · 2022: 17 · 2021: 29 · 2020: 15 · 2019: 9 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 7 · 2014: 7 · 2013: 3 · 2012: 1
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Folia Microbiologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- oxidative stress, infectious diseases, reactive oxygen species, free radicals, myeloperoxidase, NADPH oxidase, nitric oxide synthase, cytochrome P450, xanthine oxidase, inflammation, tissue damage, host defense
- MeSH terms
- Communicable Diseases, Cytochrome P-450 Enzyme System, Free Radicals, Humans, Metals, Peroxidase, Xanthine Oxidase, Oxidative Stress, Nitric Oxide Synthase, NADPH Oxidases, Metabolic Networks and Pathways
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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