Cited by 178Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietBarrier Structure and Function Studies

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Do polyphenols enter the brain and does it matter? Some theoretical and practical considerations

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Schaffer, Sebastian, Halliwell, Barry·2012·Genes & Nutrition

DOI 10.1007/s12263-011-0255-5PMC PMC3316747

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Abstract

Although several epidemiological and intervention studies suggest that polyphenols (PPs) and PP-rich foods may improve memory and cognition in animals and humans, PPs' mode of action is only poorly understood. To help distinguish between the different modes of action that have been proposed for PPs, it is obviously important to know how much PPs can accumulate in the brain, if any at all. However, reliable data on PP uptake into the brain of animals are limited as many studies failed to report important control procedures during data acquisition. In this paper, we summarize published data on the penetration of PPs into animal brain and review some hypotheses to explain the biological basis of potentially health-beneficial effects of PPs to the brain. Finally, we highlight promising new approaches, especially those of a hormetic dose-response and gut microbiota-brain interaction, which may allow a better understanding of PPs' mode of action in animals and humans.

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Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon?
LOTITO, S. B., & Frei, B. B. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.033 · Cited by 780
Retracted
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Free Radicals in Biology and Medicine
Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990
Self-citation
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228
Oxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614
Self-citation
The Relative Antioxidant Activities of Plant-Derived Polyphenolic Flavonoids
Rice-Evans, C. A., Miller, N. J., Bolwell, P., Bramley, P. M., & Pridham, J. B. (1995) · Free Radical Research · doi:10.3109/10715769509145649 · Cited by 2,160
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · cited 3×
“…of this bidirectional interaction are well established, for instance the effect of mucosal inflammation on pain reception, effects of gut microbiota on other CNS-regulated phenomena such as mood changes or anxious behaviour have only recently been described (Forsythe et al. 2010; Rhee et al. 2009).”
Biotransformation of Curcumin Through Reduction and Glucuronidation in Mice
Pan, M., Huang, T., & Lin, J. (1999) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)15211-7 · Cited by 950
Ascorbate regulation and its neuroprotective role in the brain
Rice, M. E. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01543-x · Cited by 835

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Losada‐Barreiro, S., & Bravo‐Díaz, C. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.03.061 · Cited by 304
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Godos, J., Currenti, W., Angelino, D., Mena, P. R., Castellano, S., Caraci, F., Galvano, F., Rio, D. D., Ferri, R., & Grosso, G. (2020) · Antioxidants · doi:10.3390/antiox9040346 · Cited by 274
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Authors: Schaffer, S., & Halliwell, B.
Affiliations: National University of Singapore (SG)
Corresponding author: Halliwell, Barry
ORCID: Halliwell, Barry
Venue: Genes & Nutrition
Publisher: Springer Science and Business Media LLC
Published: 2011-10-20
Volume: 7
Issue: 2
Pages: 99-109
ISSN: 1555-8932 (ISSN-L)
1865-3499
DOI: 10.1007/s12263-011-0255-5
PMC: PMC3316747
OpenAlex: W2095447381
Cited by: 178
References: 120
Citations by year: 2026: 7 · 2025: 5 · 2024: 3 · 2023: 17 · 2022: 11 · 2021: 13 · 2020: 16 · 2019: 14 · 2018: 9 · 2017: 14 · 2016: 16 · 2015: 20 · 2014: 18 · 2013: 6 · 2012: 9
FWCI: 6.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Genes & Nutrition (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: polyphenols, brain penetration, cognitive function, memory, mechanism of action, gut-brain axis, polyphenol-rich foods, animal studies

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Do polyphenols enter the brain and does it matter? Some theoretical and practical considerations

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