Polyphenols: Food sources and bioavailability

Manach, Claudine; Scalbert, Augustin; Morand, Christine; Rémésy, Christian; Jiménez, Liliana

doi:10.1093/ajcn/79.5.727

Cited by 8,175Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietPomegranate: compositions and health benefits

Polyphenols: Food sources and bioavailability

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Manach, Claudine, Scalbert, Augustin, Morand, Christine, Rémésy, Christian, Jiménez, Liliana·2004·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/79.5.727

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Abstract

Polyphenols are abundant micronutrients in our diet, and evidence for their role in the prevention of degenerative diseases such as cancer and cardiovascular diseases is emerging. The health effects of polyphenols depend on the amount consumed and on their bioavailability. In this article, the nature and contents of the various polyphenols present in food sources and the influence of agricultural practices and industrial processes are reviewed. Estimates of dietary intakes are given for each class of polyphenols. The bioavailability of polyphenols is also reviewed, with particular focus on intestinal absorption and the influence of chemical structure (eg, glycosylation, esterification, and polymerization), food matrix, and excretion back into the intestinal lumen. Information on the role of microflora in the catabolism of polyphenols and the production of some active metabolites is presented. Mechanisms of intestinal and hepatic conjugation (methylation, glucuronidation, sulfation), plasma transport, and elimination in bile and urine are also described. Pharmacokinetic data for the various polyphenols are compared. Studies on the identification of circulating metabolites, cellular uptake, intracellular metabolism with possible deconjugation, biological properties of the conjugated metabolites, and specific accumulation in some target tissues are discussed. Finally, bioavailability appears to differ greatly between the various polyphenols, and the most abundant polyphenols in our diet are not necessarily those that have the best bioavailability profile. A thorough knowledge of the bioavailability of the hundreds of dietary polyphenols will help us to identify those that are most likely to exert protective health effects.

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19 of the 306 references couldn’t be matched to a known paper.

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Coffee and Health: A Review of Recent Human Research
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Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects
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Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action
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Functional Properties of Coffee and Coffee By-Products
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Phenolic compounds in coffee
Farah, A., & Donangelo, C. M. (2006) · Brazilian Journal of Plant Physiology · doi:10.1590/s1677-04202006000100003 · Cited by 840 · see citing works
Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans
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The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature
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The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility
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Retracted
Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry Extracts Inhibit Growth and Stimulate Apoptosis of Human Cancer Cells in Vitro
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Natural polyphenols: An overview
Abbas, M., Saeed, F., Anjum, F. M., Afzaal, M., Tufail, T., Bashir, M. S., Ishtiaq, A., Hussain, S., & Suleria, H. A. R. (2017) · International Journal of Food Properties · doi:10.1080/10942912.2016.1220393 · Cited by 769 · see citing works
Flavonoids in Cancer and Apoptosis
Abotaleb, M., Samuel, S. M., Varghese, E., Varghese, S., Kubatka, P., Líšková, A., & Büsselberg, D. (2018) · Cancers · doi:10.3390/cancers11010028 · Cited by 759 · see citing works
Antioxidant capacity, phenol, anthocyanin and ascorbic acid contents in raspberries, blackberries, red currants, gooseberries and Cornelian cherries
Pantelidis, G., VASILAKAKIS, M. D., Manganaris, G. Α., & Diamantidis, G. C. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.06.021 · Cited by 752 · see citing works
Natural Polyphenols for Prevention and Treatment of Cancer
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Application of Deep Eutectic Solvents (DES) for Phenolic Compounds Extraction: Overview, Challenges, and Opportunities
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Intake and bioaccessibility of total polyphenols in a whole diet
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Polyphenol Composition and in Vitro Antioxidant Activity of Amaranth, Quinoa Buckwheat and Wheat as Affected by Sprouting and Baking
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The flavonoid quercetin in disease prevention and therapy: Facts and fancies
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Metabolite Profiling of Grape: Flavonols and Anthocyanins
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Flavones: Food Sources, Bioavailability, Metabolism, and Bioactivity
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Authors: Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Institut National de la Recherche Agronomique (FR)
ORCID: Manach, Claudine
Scalbert, Augustin
Morand, Christine
Jiménez, Liliana
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2004-05
Volume: 79
Issue: 5
Pages: 727-747
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/79.5.727
OpenAlex: W1914622032
Cited by: 8,175
References: 306
Citations by year: 2026: 348 · 2025: 398 · 2024: 426 · 2023: 445 · 2022: 529 · 2021: 558 · 2020: 526 · 2019: 482 · 2018: 463 · 2017: 476 · 2016: 452 · 2015: 451 · 2014: 426 · 2013: 417 · 2012: 406
FWCI: 13.55
Type: journal article
Language: en
Update notices: erratum (2004-02-01)
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6865 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords: polyphenols, bioavailability, dietary intake, food sources, intestinal absorption, gut microbiota, conjugation, glucuronidation, sulfation, methylation, plasma transport, pharmacokinetics, polyphenol metabolites, degenerative disease prevention, cancer, cardiovascular disease
MeSH terms: Biological Availability, Flavonoids, Food Analysis, Humans, Intestinal Absorption, Phenols, Tissue Distribution, Polyphenols

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Polyphenols: Food sources and bioavailability

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