Gene Editing to the Rescue: Reversal of Social Deficits Associated with MECP2 Duplication
Open accessThe claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Restoring Mecp2 levels within the PFC in mice via CRISPR-Cas9 or DREADDS can restore some endophenotypes such as social recognition deficits or long-term retrieval of auditory conditioned fear.
“Restoring Mecp2 levels within the PFC in mice via state-of-the-art techniques such as CRISPR-Cas9 or DREADDS can restore some of the endophenotypes such as social recognition deficits or long-term retrieval of auditory conditioned fear [267, 270, 271].”
From Development of prefrontal cortex (2022) · cites this paper as [270]
In “Gene Editing to the Rescue” (page not available), the paper reports that CRISPR-Cas9 normalization of MeCP2 in the mPFC rescued social recognition deficits in male mice. It does not report using DREADDs or restoring long-term retrieval of auditory conditioned fear; instead, it says the mPFC correction failed to rectify enhanced fear learning/memory. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 10 · Cited by 5
- Authors
- Yu, Z.-X., Wang, D.-Y., & Xu, X.-H.
- Affiliations
- Chinese Academy of Sciences (CN)
- Venue
- Neuroscience Bulletin
- Published
- 2020-05-29
- Volume
- 36
- Issue
- 6
- Pages
- 567-569
- ISSN
- 1995-8218 (ISSN-L)
- 1673-7067
- PMC
- PMC7270302
- OpenAlex
- W3031198152
- Cited by
- 5
- References
- 10
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neuroscience Bulletin (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- genome editing, social dysfunction, Rett syndrome, MeCP2, social behavior, gene therapy
- MeSH terms
- Gene Editing, Animals, Prefrontal Cortex, Gene Duplication, Mice, Methyl-CpG-Binding Protein 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
