Bone marrow-derived progenitor cells are functionally impaired in ischemic heart disease
Open accessAbstract
To determine whether the presence of ischemic heart disease (IHD) per se, or rather the co-presence of heart failure (HF), is the primum movens for less effective stem cell products in autologous stem cell therapy, we assessed numbers and function of bone marrow (BM)-derived progenitor cells in patients with coronary artery disease (n = 17), HF due to ischemic cardiomyopathy (n = 8), non-ischemic HF (n = 7), and control subjects (n = 11). Myeloid and erythroid differentiation capacity of BM-derived mononuclear cells was impaired in patients with underlying IHD but not with non-ischemic HF. Migration capacity decreased with increasing IHD severity. Hence, IHD, with or without associated cardiomyopathy, is an important determinant of progenitor cell function. No depletion of hematopoietic and endothelial progenitor cells (EPC) within the BM was observed, while circulating EPC numbers were increased in the presence of IHD, suggesting active recruitment. The observed myelosuppression was not driven by inflammation and thus other mechanisms are at play.
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In ischaemic heart failure patients, bone marrow-derived angiogenic cells are severely impaired and display markers of senescence, disabling their use for patient-derived cellular therapy.
“In ischaemic heart failure patients, these cells are severely impaired186,187 and display markers of senescence,188,189 disabling their use for patient-derived cellular therapy.”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [187]
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Cites
General Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study
D’Agostino, R. B., Vasan, R. S., Pencina, M. J., Wolf, P. A., Cobain, M., Massaro, J. M., & Kannel, W. B. (2008) · Circulation · doi:10.1161/circulationaha.107.699579 · Cited by 7,491 · see citing works
Bone marrow cells regenerate infarcted myocardium
Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S. M., Li, B., Pickel, J. M., McKay, R. D. G., Nadal‐Ginard, B., Bodine, D. M., et al. (2001) · Nature · doi:10.1038/35070587 · Cited by 5,149 · see citing works
Bellini, M., Charalampidis, S., Herbert, P., Bonatsos, V., Crane, J., Muthusamy, A., Dor, F., & Papalois, V. E. (2022) · BioMed Research International · doi:10.1155/2738 · Cited by 2,431 · see citing works
Vasa‐Nicotera, M., Fichtlscherer, S., Aicher, A., Adler, K., Urbich, C., Martin, H., Zeiher, A. M., & Dimmeler, S. (2001) · Circulation Research · doi:10.1161/hh1301.093953 · Cited by 2,328 · see citing works
The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease.
Sianos, G., Morel, M., Kappetein, A. P., Morice, M., Colombo, A., Dawkins, K. D., van den Brand, M., Dyck, N. V., Russell, M. E., Mohr, F. W., et al. (2005) · PubMed · Cited by 2,242 · see citing works
Ren, G., Zhang, L., Zhao, X., Xu, G., Zhang, Y., Roberts, A. I., Zhao, R. C., & Shi, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.11.014 · Cited by 2,101 · see citing works
Babitt, J. L., & Lin, H. Y. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011111078 · Cited by 1,041 · see citing works
HMG-CoA reductase inhibitor mobilizes bone marrow–derived endothelial progenitor cells
Llevadot, J., Murasawa, S., Kureishi, Y., Uchida, S., Masuda, H., Kawamoto, A., Walsh, K., Isner, J. M., & Asahara, T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13131 · Cited by 701 · see citing works
Heeschen, C., Lehmann, R., Honold, J., Aßmus, B., Aicher, A., Walter, D. H., Martin, H., Zeiher, A. M., & Dimmeler, S. (2004) · Circulation · doi:10.1161/01.cir.0000124476.32871.e3 · Cited by 617 · see citing works
HMG-CoA reductase inhibitor mobilizes bone marrow–derived endothelial progenitor cells
Llevadot, J., Murasawa, S., Kureishi, Y., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113131 · Cited by 611 · see citing works
Lipinski, M. J., Biondi‐Zoccai, G., Abbate, A., Khianey, R., Sheiban, I., Bartunek, J., Vanderheyden, M., Kim, H.-S., Kang, H., Strauer, B. E., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.041 · Cited by 507 · see citing works
Perin, E. C., Willerson, J. T., Pepine, C. J., Henry, T. D., Ellis, S. G., Zhao, D. X.-M., Silva, G. V., Lai, D., Thomas, J. D., Kronenberg, M. W., et al. (2012) · JAMA · doi:10.1001/jama.2012.418 · Cited by 460 · see citing works
Aging and disease as modifiers of efficacy of cell therapy
Dimmeler, S., & Leri, A. (2008) · Circulation Research · doi:10.1161/circresaha.108.175943 · Cited by 379 · see citing works
CD34 + and Endothelial Progenitor Cells in Patients With Various Degrees of Congestive Heart Failure
Valgimigli, M., Rigolin, G. M., Fucili, A., Porta, M. G. D., Soukhomovskaia, O., Malagutti, P., Bugli, A. M., Bragotti, L. Z., Francolini, G., Mauro, E., et al. (2004) · Circulation · doi:10.1161/01.cir.0000136813.89036.21 · Cited by 372 · see citing works
Folia Histochemica et Cytobiologica
(2012) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc · Cited by 315 · see citing works
Kissel, C. K., Lehmann, R., Aßmus, B., Aicher, A., Honold, J., Fischer‐Rasokat, U., Heeschen, C., Spyridopoulos, I., Dimmeler, S., & Zeiher, A. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.01.095 · Cited by 241 · see citing works
Tongers, J., Losordo, D. W., & Landmesser, U. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr018 · Cited by 241 · see citing works
Aßmus, B., Fischer‐Rasokat, U., Honold, J., Seeger, F. H., Fichtlscherer, S., Tonn, T., Seifried, E., Schächinger, V., Dimmeler, S., & Zeiher, A. M. (2007) · Circulation Research · doi:10.1161/01.res.0000264508.47717.6b · Cited by 216 · see citing works
Adult Bone Marrow Cell Therapy for Ischemic Heart Disease
Afzal, M. R., Samanta, A., Shah, Z. I., Jeevanantham, V., Abdel‐Latif, A., Zuba‐Surma, E. K., & Dawn, B. (2015) · Circulation Research · doi:10.1161/circresaha.114.304792 · Cited by 210 · see citing works
Meta-Analysis of Cell Therapy Trials for Patients With Heart Failure
Fisher, S. A., Doree, C. J., Mathur, A., & Martin‐Rendon, E. (2015) · Circulation Research · doi:10.1161/circresaha.116.304386 · Cited by 202 · see citing works
Pronk, C. J., Veiby, O. P., Bryder, D., & Jacobsen, S. E. W. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110752 · Cited by 196 · see citing works
Tumor Necrosis Factor Receptors Types 1 and 2 Differentially Regulate Osteoclastogenesis
Abu‐Amer, Y., Erdmann, J. M., Alexopoulou, L., Kollias, G. A., Ross, F. P., & Teitelbaum, S. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003886200 · Cited by 195 · see citing works
Delewi, R., Hirsch, A., Tijssen, J. G. P., Schächinger, V., Wojakowski, W., Roncalli, J. G., Aakhus, S., Erbs, S., Aßmus, B., Tendera, M., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht372 · Cited by 141 · see citing works
Jakob, P., Doerries, C., Schumacher, S. B., Mocharla, P. S., Kränkel, N., Besler, C., Mueller, M. F., Manes, C., Templin, C., Baltes, C., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.093906 · Cited by 126 · see citing works
Bone Marrow Dysfunction in Chronic Heart Failure Patients
Westenbrink, B. D., Voors, A. A., de Boer, R. A., Schuringa, J. J., Klinkenberg, T. J., van der Harst, P., Vellenga, E., van Veldhuisen, D. J., & van Gilst, W. H. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq061 · Cited by 116 · see citing works
Lin, C.-P., Lin, F., Huang, P., Chen, Y., Chen, W., Chen, H.-Y., Huang, Y.-C., Liao, W., Huang, H., Liu, P., et al. (2012) · BioMed Research International · doi:10.1155/2013/845037 · Cited by 99 · see citing works
Chen, X., & Oppenheim, J. J. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.04.025 · Cited by 97 · see citing works
Myeloid suppressor cells require membrane TNFR2 expression for suppressive activity
Polz, J., Remke, A., Weber, S., Schmidt, D., Weber‐Steffens, D., Pietryga‐Krieger, A., Müller, N. C., Ritter, U., Mostböck, S., & Männel, D. N. (2014) · Immunity Inflammation and Disease · doi:10.1002/iid3.19 · Cited by 92 · see citing works
Hamshere, S. M., Arnous, S., Choudhury, T. R., Choudry, F., Mozid, A. M., Yeo, C., Barrett, C., Saunders, N., Gulati, A., Knight, C. J., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv390 · Cited by 90 · see citing works
What causes the symptoms of heart failure?
Coats, A. J. S. (2001) · Heart · doi:10.1136/heart.86.5.574 · Cited by 78 · see citing works
Mangialardi, G., Katare, R., Oikawa, A., Meloni, M., Reni, C., Emanueli, C., & Madeddu, P. R. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300424 · Cited by 68 · see citing works
Spyridopoulos, I., Erben, Y., Brümmendorf, T. H., Haendeler, J., Dietz, K., Seeger, F. H., Kissel, C. K., Martin, H., Hoffmann, J., Aßmus, B., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.160846 · Cited by 68 · see citing works
Cogle, C. R., Wise, E. A., Meacham, A. M., Zierold, C., Traverse, J. H., Henry, T. D., Perin, E. C., Willerson, J. T., Ellis, S. G., Carlson, M., et al. (2014) · Circulation Research · doi:10.1161/circresaha.115.304353 · Cited by 67 · see citing works
Craenenbroeck, E. M. V., Craenenbroeck, A. H. V., van Ierssel, S. H., Bruyndonckx, L., Hoymans, V. Y., Vrints, C. J., & Conraads, V. M. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.10.047 · Cited by 66 · see citing works
Self-citationGajkowska, A., Ołdak, T., Jastrzewska, M., Machaj, E. K., Walewski, J. A., Kraszewska, E., & Pojda, Z. (2006) · PubMed · doi:10.5603/4589 · Cited by 58 · see citing works
Kappen, C. (2000) · American Journal of Hematology · doi:10.1002/1096-8652(200010)65:2 · Cited by 56 · see citing works
Diabetes impairs mobilization of stem cells for the treatment of cardiovascular disease
Fadini, G. P., & Avogaro, A. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.10.089 · Cited by 50 · see citing works
Cangiano, E., Marchesini, J., Campo, G. C., Francolini, G., Fortini, C., Carrà, G., Miccoli, M., Ceconi, C., Tavazzi, L., & Ferrari, R. (2011) · American Journal of Cardiovascular Drugs · doi:10.2165/11589400-000000000-00000 · Cited by 44 · see citing works
Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease
Liguori, A., Fiorito, C., Balestrieri, M. L., Crimi, E., Bruzzese, G., Williams‐Ignarro, S., D’Amora, M., Sommese, L., Grimaldi, V., Minucci, P. B., et al. (2007) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2007.01007.x · Cited by 41 · see citing works
Hematopoietic Progenitor Cell Mobilization Is Mediated Through β-2 and β-3 Receptors After Injury
Beiermeister, K. A., Keck, B. M., Sifri, Z. C., Elhassan, I. O., Hannoush, E. J., Alzate, W. D., Rameshwar, P., Livingston, D. H., & Mohr, A. M. (2010) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181e5d35e · Cited by 38 · see citing works
Identification of early myeloid progenitors as immunosuppressive cells
Pu, S., Qin, B., He, H., Zhan, J., Wu, Q., Zhang, X., Yang, L., Qu, C., & Zhou, Z. (2016) · Scientific Reports · doi:10.1038/srep23115 · Cited by 31 · see citing works
SANT'ANNA, R. T., Fracasso, J., Valle, F. H., Castro, I., Nardi, N. B., Sant'Anna, J. R. M., Nesralla, I. A., & Kalil, R. A. K. (2014) · Brazilian Journal of Cardiovascular Surgery · doi:10.5935/1678-9741.20140091 · Cited by 29 · see citing works
Expression of tumor necrosis factor alpha and its receptors during cellular differentiation
Schling, P., Rudolph, C., Heimerl, S., Fruth, S., & Schmitz, G. (2006) · Cytokine · doi:10.1016/j.cyto.2006.02.007 · Cited by 26 · see citing works
Bozdağ-Turan, İ., Turan, R. G., Paranskaya, L., Arsoy, N. S., Turan, C. H., Akın, İ., Kische, S., Ortak, J., Schneider, H., Ludovicy, S., et al. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-143 · Cited by 20 · see citing works
Improving stem cell therapy in cardiovascular diseases: the potential role of microRNA
Nollet, E., Hoymans, V. Y., Craenenbroeck, A. H. V., Vrints, C. J., & Craenenbroeck, E. M. V. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00239.2016 · Cited by 12 · see citing works
Self-citationSchündeln, M. M., Walde, G., Basu, O., Havers, W., & Kremens, B. (2014) · Pediatric Hematology and Oncology · doi:10.3109/08880018.2013.874513 · Cited by 8 · see citing works
Nollet, E., Craenenbroeck, E. M. V., Martinet, W., Rodrigus, I. R., Bock, D. D., Berneman, Z. N., Pintelon, I., Ysebaert, D., Vrints, C. J., Conraads, V. M., et al. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.04.013 · Cited by 6 · see citing works
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Stojanović, S. D., Fiedler, J., Bauersachs, J., Thum, T., & Sedding, D. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz919 · Cited by 188 · see citing works
Adverse Cardiac Remodelling after Acute Myocardial Infarction: Old and New Biomarkers
Berezin, A. Е., & Berezin, A. A. (2020) · Disease Markers · doi:10.1155/2020/1215802 · Cited by 155 · see citing works
Liu, D., Gu, G., Gan, L., Yan, W., Zhang, Z., Yao, P., Zhu, D., Lau, W. B., Xie, D., Wu, S., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101929 · Cited by 20 · see citing works
Nollet, E., Hoymans, V. Y., Rodrigus, I. R., De Bock, D., Dom, M., Van Hoof, V. O. M., Vrints, C. J., & Van Craenenbroeck, E. M. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.03.023 · Cited by 17 · see citing works
Self-citationWang, M., Yang, D., Zhao, H., Shi, Y., Ma, Y., Cao, X., Guo, T., Cai, H., & Cai, H. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.747497 · Cited by 12 · see citing works
Rethineswaran, V. K., Kim, Y.-J., Jang, W. B., Ji, S. T., Kang, S., Kim, D. Y., Park, J., Van, L. T. H., Giang, L. T. T., Ha, J. S., et al. (2019) · Marine Drugs · doi:10.3390/md17070392 · Cited by 8 · see citing works
Ma, Y., Zhao, H., Yang, D., Li, L., Wang, L., Xiao, J., Cao, X., Shi, Y., & Cai, H. (2020) · PubMed Central · Cited by 7 · see citing works
Ayuningtyas, W., Noverina, R., Kurniawan, D., Khairani, A. F., Atik, N., Wirakusumah, F. F., & Faried, A. (2021) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2021.5625
- Authors
- Nollet, E., Hoymans, V. Y., Rodrigus, I. R., De Bock, D., Dom, M., Vanassche, B., Van Hoof, V. O. M., Cools, N., Van Ackeren, K., Wouters, K., Vermeulen, K., Vrints, C. J., & Van Craenenbroeck, E. M.
- Affiliations
- University of Antwerp (BE)
- Antwerp University Hospital (BE)
- Corresponding author
- Nollet, Evelien
- ORCID
- Venue
- Journal of Cardiovascular Translational Research
- Published
- 2016-07-25
- Volume
- 9
- Issue
- 4
- Pages
- 266-278
- ISSN
- 1937-5387 (ISSN-L)
- 1937-5395
- PMC
- PMC5031720
- OpenAlex
- W2479672129
- Cited by
- 8
- References
- 46
- Citations by year
- 2021: 3 · 2020: 2 · 2019: 2 · 2017: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Cardiovascular Translational Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- FWO Flanders (G060321N, Senior clinical investigator)
- University of Antwerp (Research grant)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- ischemic heart disease, bone marrow progenitor cells, endothelial progenitor cells, heart failure, ischemic cardiomyopathy, autologous stem cell therapy, myeloid differentiation, erythroid differentiation, cell migration, myelosuppression, coronary artery disease
- MeSH terms
- Adult, Aged, Alkaline Phosphatase, Bone Marrow Cells, Cell Differentiation, Cell Movement, Cells, Cultured, Coronary Artery Disease, Female, Hematopoietic Stem Cells, Humans, Male, Middle Aged, Cardiomyopathies, Phenotype, Biomarkers, Case-Control Studies, Cytokines, Myocardial Ischemia, Receptors, Cytokine, Inflammation Mediators, Angiogenic Proteins, Endothelial Progenitor Cells
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