The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases
Abstract
Nitric oxide (NO) is a pivotal signaling messenger in the cardiovascular system. NO participates in regulatory functions including control of hemostasis, fibrinolysis, platelet and leukocyte interactions with the arterial wall, regulation of vascular tone, proliferation of vascular smooth muscle cells, and homeostasis of blood pressure. Diminished NO bioavailability and abnormalities in NO-dependent signaling are among central factors of vascular disease, although it is unclear whether this is a cause of, or result of endothelial dysfunction or both pathogenic events. Disturbances in NO bioavailability have been linked to cause endothelial dysfunction, leading to increased susceptibility to atherosclerotic lesion progression, hypertension, hypercholesterolemia, diabetes mellitus, thrombosis and stroke.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Similarly, vascular disease, cardiovascular disease (CVD), and metabolic syndrome all share effective loss of NO function[23,35–39].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [35]
Citations
Cites
Dynamic activation of endothelial nitric oxide synthase by Hsp90
García‐Cardeña, G., Fan, R., Shah, V. H., Sorrentino, R., Cirino, G., Papapetropoulos, A., & Sessa, W. C. (1998) · Nature · doi:10.1038/33934 · Cited by 1,029
Nitric Oxide as a Signaling Molecule in the Vascular System: An Overview
Ignarro, L. J., Cirino, G., Casini, A., & Claudio Napoli, A. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199912000-00016 · Cited by 767
Self-citationKLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation
SenBanerjee, S., Lin, Z., Atkins, G. B., Greif, D. M., Rao, R. M., Kumar, A., Feinberg, M. W., Chen, Z., Simon, D. I., Luscinskas, F. W., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031132 · Cited by 734
Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2
Parmar, K. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24787 · Cited by 710
Doughan, A. K., Harrison, D. G., & Dikalov, S. I. (2008) · Circulation Research · doi:10.1161/circresaha.107.162800 · Cited by 710
Nitric Oxide Donors and Cardiovascular Agents Modulating the Bioactivity of Nitric Oxide
Ignarro, L. J., Claudio Napoli, A., & Loscalzo, J. (2002) · Circulation Research · doi:10.1161/hh0102.102330 · Cited by 495
Self-citationNitric oxide and atherosclerosis: An update
Claudio Napoli, A., de Nigris, F., Williams‐Ignarro, S., Pignalosa, O., Sica, V., & Ignarro, L. J. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.03.011 · Cited by 471
Self-citationRole of Krüppel-Like Transcription Factors in Endothelial Biology
Atkins, G. B., & Jain, M. K. (2007) · Circulation Research · doi:10.1161/01.res.0000267856.00713.0a · Cited by 422
Kruppel-Like Factor 2 (KLF2) Regulates Endothelial Thrombotic Function
Lin, Z., Kumar, A., SenBanerjee, S., Staniszewski, K. E., Parmar, K. M., Vaughan, D. E., Gimbrone, M. A., Balasubramanian, V., García‐Cardeña, G., & Jain, M. K. (2005) · Circulation Research · doi:10.1161/01.res.0000159707.05637.a1 · Cited by 385
Nitric Oxide and Atherosclerosis
Claudio Napoli, A., & Ignarro, L. J. (2001) · Nitric Oxide · doi:10.1006/niox.2001.0337 · Cited by 374
Self-citationDekker, R. J., Boon, R. A., Rondaij, M. G., Kragt, A., Volger, O. L., Elderkamp, Y. W., Meijers, J. C. M., Voorberg, J., Pannekoek, H., & Horrevoets, A. J. G. (2006) · Blood · doi:10.1182/blood-2005-08-3465 · Cited by 366
Dekker, R. J., van Thienen, J. V., Rohlena, J., de Jager, S. C. A., Elderkamp, Y. W., Seppen, J., de Vries, C. J. M., Biessen, E. A. L., van Berkel, T. J. C., Pannekoek, H., et al. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63002-7 · Cited by 355
Liu, V. W. T., & Huang, P. L. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.06.024 · Cited by 263
Statins Exert Endothelial Atheroprotective Effects via the KLF2 Transcription Factor
Parmar, K. M., Nambudiri, V. E., Dai, G., Larman, H. B., Gimbrone, M. A., & García‐Cardeña, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500144200 · Cited by 255
Claudio Napoli, A., & Ignarro, L. J. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140226 · Cited by 218
Self-citationGoya, K., Sumitani, S., Xu, X., Kitamura, T., Yamamoto, H., Kurebayashi, S., Saito, H., Kouhara, H., Kasayama, S., & Kawase, I. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000118682.58708.78 · Cited by 174
Fledderus, J. O., van Thienen, J. V., Boon, R. A., Dekker, R. J., Rohlena, J., Volger, O. L., Bijnens, A. P., Daemen, M. J. A. P., Kuiper, J., van Berkel, T. J. C., et al. (2007) · Blood · doi:10.1182/blood-2006-07-036020 · Cited by 150
Lavi, S., Yang, E. H., Prasad, A., Mathew, V., Barsness, G. W., Rihal, C. S., Lerman, L. O., & Lerman, A. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.099986 · Cited by 150
Maniatis, N. A., Brovkovych, V. M., Allen, S. E., John, T. A., Shajahan‐Haq, A. N., Tiruppathì, C., Vogel, S. M., Skidgel, R. A., Malik, A. B., & Minshall, R. D. (2006) · Circulation Research · doi:10.1161/01.res.0000245187.08026.47 · Cited by 141
D'Armiento, F. P., Bianchi, A., de Nigris, F., Capuzzi, D. M., D'Armiento, M. R., Crimi, G., Abete, P., Palinski, W., Condorelli, M., Napoli, C., et al. (2001) · Stroke · doi:10.1161/hs1101.098520 · Cited by 137
KLF2 Suppresses TGF-β Signaling in Endothelium Through Induction of Smad7 and Inhibition of AP-1
Boon, R. A., Fledderus, J. O., Volger, O. L., van Wanrooij, E. J. A., Pardali, E., Weesie, F., Kuiper, J., Pannekoek, H., ten Dijke, P., & Horrevoets, A. J. G. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000256466.65450.ce · Cited by 121
Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis
Ignarro, L. J., & Claudio Napoli, A. (2005) · Current Diabetes Reports · doi:10.1007/s11892-005-0062-8 · Cited by 120
Self-citationNapoli, C., Witztum, J. L., de Nigris, F., Palumbo, G., D’Armiento, F. P., & Palinski, W. (1999) · Circulation · doi:10.1161/01.cir.99.15.2003 · Cited by 110
Oxidation-sensitive mechanisms, vascular apoptosis and atherosclerosis
de Nigris, F., Lerman, A., Ignarro, L. J., Williams‐Ignarro, S., Sica, V., Baker, A. H., Lerman, L. O., Geng, Y., & Claudio Napoli, A. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00139-4 · Cited by 107
Self-citationGoodwin, B. L., Solomonson, L. P., & Eichler, D. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308160200 · Cited by 100
Oxidative Stress, Nitric Oxide Synthase, and Superoxide Dismutase
Schiffrin, E. L. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.103226 · Cited by 96
Endothelial Nitric Oxide Synthase
Rabelink, T. J., & Lüscher, T. F. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000196554.85799.77 · Cited by 92
Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis
Ignarro, L. J., & Claudio Napoli, A. (2004) · Current Atherosclerosis Reports · doi:10.1007/s11883-004-0059-9 · Cited by 91
Self-citationInvolvement of Oxidation-Sensitive Mechanisms in the Cardiovascular Effects of Hypercholesterolemia
Claudio Napoli, A., & Lerman, L. O. (2001) · Mayo Clinic Proceedings · doi:10.4065/76.6.619 · Cited by 84
The role of caveolin-1 in PCB77-induced eNOS phosphorylation in human-derived endothelial cells
Lim, E. J., Smart, E. J., Toborek, M. J., & Hennig, B. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00921.2007 · Cited by 58
Hayashi, T., Juliet, P. A. R., Miyazaki, A., Ignarro, L. J., & Iguchi, A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.11.011 · Cited by 57
Self-citationClaudio Napoli, A., Paternò, R., Faraci, F. M., Taguchi, H., Postiglione, A., & Heistad, D. D. (1997) · Stroke · doi:10.1161/01.str.28.11.2266 · Cited by 52
Bouhlel, M. A., Staels, B., & Chinetti‐Gbaguidi, G. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01892.x · Cited by 51
Cao, S., Yao, J. Z., & Shah, V. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212546200 · Cited by 49
Peroxisome Proliferator-Activated Receptor-Alpha and Atherosclerosis
Israelian-Konaraki, Z., & Reaven, P. D. (2005) · Cardiology in Review · doi:10.1097/01.crd.0000137255.54390.12 · Cited by 49
Claudio Napoli, A., Lerman, L. O., de Nigris, F., Loscalzo, J., & Ignarro, L. J. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02306-9 · Cited by 42
Self-citationPolymorphisms in endothelial nitric oxide synthase and carotid artery atherosclerosis: Table 1
Napoli, C., & Ignarro, L. J. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2006.040550 · Cited by 23
Self-citation
Cited by
Sorted by citations
cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action
Francis, S. H., Busch, J. L., & Corbin, J. D. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002907 · Cited by 1,059
Calabrese, V., Cornelius, C., Dinkova‐Kostova, A. T., Calabrese, E. J., & Mattson, M. P. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3074 · Cited by 817
Cocoa and Chocolate in Human Health and Disease
Katz, D. L., Doughty, K. N., & Ali, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3697 · Cited by 475
Mitochondria and Reactive Oxygen Species: Physiology and Pathophysiology
Bolisetty, S., & Jaimes, E. A. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036306 · Cited by 287
Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity
Mladěnka, P., Zatloukalová, L., Filipský, T., & Hrdina, R. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.06.010 · Cited by 256
Metadata
- Authors
- Napoli, C., & Ignarro, L. J.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Archives of Pharmacal Research
- Published
- 2009-08
- Volume
- 32
- Issue
- 8
- Pages
- 1103-1108
- ISSN
- 0253-6269 (ISSN-L)
- 1976-3786
- OpenAlex
- W2049131838
- Cited by
- 281
- References
- 37
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 11 · 2023: 5 · 2022: 15 · 2021: 9 · 2020: 15 · 2019: 16 · 2018: 18 · 2017: 20 · 2016: 9 · 2015: 18 · 2014: 23 · 2013: 17 · 2012: 24
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Pharmacal Research (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- nitric oxide, NO bioavailability, endothelial dysfunction, vascular disease, atherosclerosis, hypertension, hypercholesterolemia, diabetes mellitus, thrombosis, stroke, vascular tone, vascular smooth muscle cell proliferation, hemostasis, fibrinolysis
- MeSH terms
- Animals, Humans, Nitric Oxide, Oxidation-Reduction, Vascular Diseases, Kruppel-Like Transcription Factors, Nitric Oxide Synthase Type III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
