The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases
Abstract
Nitric oxide (NO) is a pivotal signaling messenger in the cardiovascular system. NO participates in regulatory functions including control of hemostasis, fibrinolysis, platelet and leukocyte interactions with the arterial wall, regulation of vascular tone, proliferation of vascular smooth muscle cells, and homeostasis of blood pressure. Diminished NO bioavailability and abnormalities in NO-dependent signaling are among central factors of vascular disease, although it is unclear whether this is a cause of, or result of endothelial dysfunction or both pathogenic events. Disturbances in NO bioavailability have been linked to cause endothelial dysfunction, leading to increased susceptibility to atherosclerotic lesion progression, hypertension, hypercholesterolemia, diabetes mellitus, thrombosis and stroke.
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“Similarly, vascular disease, cardiovascular disease (CVD), and metabolic syndrome all share effective loss of NO function[23,35–39].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [35]
Citations
Cites
Dynamic activation of endothelial nitric oxide synthase by Hsp90
García‐Cardeña, G., Fan, R., Shah, V. H., Sorrentino, R., Cirino, G., Papapetropoulos, A., & Sessa, W. C. (1998) · Nature · doi:10.1038/33934 · Cited by 1,029
Nitric Oxide as a Signaling Molecule in the Vascular System: An Overview
Ignarro, L. J., Cirino, G., Casini, A., & Claudio Napoli, A. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199912000-00016 · Cited by 767
Self-citationKLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation
SenBanerjee, S., Lin, Z., Atkins, G. B., Greif, D. M., Rao, R. M., Kumar, A., Feinberg, M. W., Chen, Z., Simon, D. I., Luscinskas, F. W., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031132 · Cited by 734
Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2
Parmar, K. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24787 · Cited by 710
Doughan, A. K., Harrison, D. G., & Dikalov, S. I. (2008) · Circulation Research · doi:10.1161/circresaha.107.162800 · Cited by 710
Nitric Oxide Donors and Cardiovascular Agents Modulating the Bioactivity of Nitric Oxide
Ignarro, L. J., Claudio Napoli, A., & Loscalzo, J. (2002) · Circulation Research · doi:10.1161/hh0102.102330 · Cited by 495
Self-citationNitric oxide and atherosclerosis: An update
Claudio Napoli, A., de Nigris, F., Williams‐Ignarro, S., Pignalosa, O., Sica, V., & Ignarro, L. J. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.03.011 · Cited by 471
Self-citationRole of Krüppel-Like Transcription Factors in Endothelial Biology
Atkins, G. B., & Jain, M. K. (2007) · Circulation Research · doi:10.1161/01.res.0000267856.00713.0a · Cited by 422
Kruppel-Like Factor 2 (KLF2) Regulates Endothelial Thrombotic Function
Lin, Z., Kumar, A., SenBanerjee, S., Staniszewski, K. E., Parmar, K. M., Vaughan, D. E., Gimbrone, M. A., Balasubramanian, V., García‐Cardeña, G., & Jain, M. K. (2005) · Circulation Research · doi:10.1161/01.res.0000159707.05637.a1 · Cited by 385
Nitric Oxide and Atherosclerosis
Claudio Napoli, A., & Ignarro, L. J. (2001) · Nitric Oxide · doi:10.1006/niox.2001.0337 · Cited by 374
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cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action
Francis, S. H., Busch, J. L., & Corbin, J. D. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002907 · Cited by 1,059
Calabrese, V., Cornelius, C., Dinkova‐Kostova, A. T., Calabrese, E. J., & Mattson, M. P. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3074 · Cited by 817
Cocoa and Chocolate in Human Health and Disease
Katz, D. L., Doughty, K. N., & Ali, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3697 · Cited by 475
Mitochondria and Reactive Oxygen Species: Physiology and Pathophysiology
Bolisetty, S., & Jaimes, E. A. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036306 · Cited by 287
Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity
Mladěnka, P., Zatloukalová, L., Filipský, T., & Hrdina, R. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.06.010 · Cited by 256
Metadata
- Authors
- Napoli, C., & Ignarro, L. J.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Archives of Pharmacal Research
- Published
- 2009-08
- Volume
- 32
- Issue
- 8
- Pages
- 1103-1108
- ISSN
- 0253-6269 (ISSN-L)
- 1976-3786
- OpenAlex
- W2049131838
- Cited by
- 281
- References
- 37
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 11 · 2023: 5 · 2022: 15 · 2021: 9 · 2020: 15 · 2019: 16 · 2018: 18 · 2017: 20 · 2016: 9 · 2015: 18 · 2014: 23 · 2013: 17 · 2012: 24
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Pharmacal Research (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- nitric oxide, NO bioavailability, endothelial dysfunction, vascular disease, atherosclerosis, hypertension, hypercholesterolemia, diabetes mellitus, thrombosis, stroke, vascular tone, vascular smooth muscle cell proliferation, hemostasis, fibrinolysis
- MeSH terms
- Animals, Humans, Nitric Oxide, Oxidation-Reduction, Vascular Diseases, Kruppel-Like Transcription Factors, Nitric Oxide Synthase Type III
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