Advances in colon-targeted nano-drug delivery systems: challenges and solutions

Colorectal cancer statistics, 2014

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Barrier properties of mucus

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Colorectal cancer

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The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

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Intestinal Inflammation and Cancer

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Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer

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Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

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Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

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Exploring β-glucan as a micro-nano system for oral delivery targeted the colon

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Transferrin modified PEG–PLGA nanoparticles: highly effective notoginsenoside R1 formulations for the treatment of ulcerative colitis

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Biomembrane‐coated nanosystems as next‐generation delivery systems for the treatment of gastrointestinal cancers

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Analysis of nanomedicine applications for inflammatory bowel disease: structural and temporal dynamics, research hotspots, and emerging trends

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Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers

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Exploring Recent Advances in Colon-targeted Drug Delivery Systems: from Traditional Methods to Advanced Technologies

Agrawal, N., Siddiqui, M. A., Gupta, S., Jaiswal, M., & Lanjhiyana, S. K. (2025) · Current Gastroenterology Reports · doi:10.1007/s11894-025-01019-w · Cited by 14

Mesoporous selenium nanoparticles for therapeutic goals: a review

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Magnetic Nanoparticles with Aspects of their Use in Cancer Therapy

Dinç, R. (2023) · Letters in Drug Design & Discovery · doi:10.2174/1570180820666230228103903 · Cited by 13

Biomimetic engineered nanocarriers inspired by viruses for oral-drug delivery

Zhang, J., Liu, X., Lin, J., Bao, X., Peng, J., Gong, Z., Luan, X., & Chen, Y. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121979 · Cited by 13

Synergistic cytotoxicity of irinotecan combined with polysaccharide-based nanoparticles for colorectal carcinoma

Pai, F.-T., & Lin, L. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213577 · Cited by 13

Recent progress in calcium carbonate nanoparticles for cancer therapy: design strategies and clinical prospects

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Progress and challenges of functionalized bacterial encapsulation: A novel biotechnology for next-generation biotherapeutics

Zhang, Y., Wu, Y., Zhao, X., Ye, Q., Cao, L., Liu, M., Gao, B., Niu, Q., Chen, N., Duan, Z., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.07.028 · Cited by 12

Selective Nanoparticulate Systems for Drug Delivery in Inflammatory Bowel Disease

Ribeiro, A., & Nunes, R. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics18010055 · Cited by 13

Ulcerative colitis alleviation of colon-specific delivered rhamnolipid/fullerene nanocomposites via dual modulation in oxidative stress and intestinal microbiome

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Recent advances in oral drug delivery materials for targeted diagnosis or treatment of gastrointestinal diseases

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pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

Kumawat, A., Karmakar, M., & Ghoroi, C. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c02769 · Cited by 12

Advances in prebiotic carbohydrate–based targeted delivery: Overcoming gastrointestinal challenges for bioactive ingredients

Zhang, Y., He, J., Zeng, H., Xu, D., Li, W., & Wang, Y. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.142210 · Cited by 12

Self-assembled calcium pyrophosphate nanostructures for targeted molecular delivery

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Dual advantages of SN38 prodrug nanoassemblies overcome defects of irinotecan and SN38: enhanced stability and activatability

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ROS/Enzyme Dual-Responsive Drug Delivery System for Targeted Colorectal Cancer Therapy: Synergistic Chemotherapy, Anti-Inflammatory, and Gut Microbiota Modulation

Zhang, X., Lian, R., Fan, B., Meng, L., Zhang, P., Zhang, Y., & Sun, W. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17070940 · Cited by 11

Improving Oral Bioavailability of Herbal Drugs: A Focused Review of Self-Emulsifying Drug Delivery System for Colon Cancer

Bhardwaj, K., Sharma, A., Kumar, R., Tyagi, V., & Kumar, R. (2023) · Current Drug Delivery · doi:10.2174/1567201820666230505113108 · Cited by 11

An evaluation of animal models for using bioactive compounds in the treatment of inflammatory bowel disease

Tie, S., Chen, Y., & Tan, M. (2024) · Food Frontiers · doi:10.1002/fft2.360 · Cited by 11

Advanced polymeric systems for colon drug delivery: from experimental models to market applications

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Short‐chain fatty acids regulate T cell heterogeneity to alleviate recurrent spontaneous abortion

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Multiparticulate Systems of Meloxicam for Colonic Administration in Cancer or Autoimmune Diseases

Ruiz, E. N., Álvarez, C., Peña, M. D. L. Á., Torrado‐Salmerón, C., Dahma, Z., & de la Torre-Iglesias, P. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071504 · Cited by 11

Fabrication, design, and in vivo investigation of mesoporous silica-based docetaxel trihydrate nanoparticles for colonic drug delivery

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Colon delivery of resveratrol for the treatment of inflammatory bowel disease

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Investigating the therapeutic promise of drug-repurposed-loaded nanocarriers: A pioneering strategy in advancing colorectal cancer treatment

Mneimneh, A. T., Darwiche, N., & Mehanna, M. M. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124473 · Cited by 11

Redox-Sensitive Linear and Cross-Linked Cystamine-Based Polymers for Colon-Targeted Drug Delivery: Design, Synthesis, and Characterisation

Ng, Y. M., Yusuf, S. N. A. M., Chiu, H. I., & Lim, V. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12050461 · Cited by 10

Ionically bridged dexamethasone sodium phosphate–zinc–PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis

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A biodegradable nanodrug with highly efficient treatment effect by remodeling tumor microenvironment and manipulating energy metabolism against colorectal cancer

Zhang, S., Zhang, H., Song, P., Cao, Y., Li, W., Wang, D., Wang, Y., & Zhang, H. (2023) · Science China Materials · doi:10.1007/s40843-023-2693-7 · Cited by 10

Recent advances in nanocarrier systems for ulcerative colitis: A new era of targeted therapy and biomarker integration

Chauhan, S., & Harwansh, R. K. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105466 · Cited by 11

Exploring the potential of metalloporphyrin-like C54N4 fullerene (TM-PC60F) nanoclusters as new drug delivery platform for 5-fluorouracil: A DFT and QTAIM study

Marlina, L. A., Hutama, A. S., Arief, I., Mazaya, M., Syafarina, I., & Saputri, W. D. (2024) · Diamond and Related Materials · doi:10.1016/j.diamond.2024.111267 · Cited by 10

Nature-inspired protein mineralization strategies for nanoparticle construction: advancing effective cancer therapy

Cao, Y., Xu, R., Liang, Y., Tan, J., Guo, X., Fang, J., Wang, S., & Xu, L. (2024) · Nanoscale · doi:10.1039/d4nr01536c · Cited by 10

Physicochemical characterization, release profile, and antibacterial mechanisms of caffeic acid phenethyl ester loaded in lipid nanocapsules with lauric acid and glycerol monolaurate

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Research progress of polysaccharide drug delivery systems in the treatment of intestinal diseases: A review

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Research progress and potential of 3D printing in development of foods for gastrointestinal target: A comprehensive review

Niu, D., Zhang, M., MUJUMDAR, A. S., & Li, J. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.105422 · Cited by 10

Cupriavidus necator-Produced Polyhydroxybutyrate/Eudragit FS Hybrid Nanoparticles Mitigates Ulcerative Colitis via Colon-Targeted Delivery of Cyclosporine A

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Multifunctional systems based on nano-in-microparticles as strategies for drug delivery: advances, challenges, and future perspectives

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Preparation of baicalin colon-targeted granules and its intervention effect on ulcerative colitis in rats

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Recognizing the biological barriers and pathophysiological characteristics of the gastrointestinal tract for the design and application of nanotherapeutics

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A bigel co-delivering highly hydrophilic and hydrophobic natural compounds for enhanced ulcerative colitis therapy

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Mapping the intellectual structure and landscape of nano-drug delivery systems in colorectal cancer

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Colon-targeted EMSCs conditional medium hydrogel for treatment of ulcerative colitis in mice

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Fabrication of pH-dependent solid dispersion for oral colon-targeted delivery of notoginsenoside R1 and its protective effects on ulcerative colitis mice

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Solidification and oral delivery of biologics to the colon- A review

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Global research progress of nanomedicine and colorectal cancer: a bibliometrics and visualization analysis

Tian, S. I. P., & Chen, M. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1460201 · Cited by 8

On-site sol-gel-sol transition of alginate enables reversible shielding/deshielding of tumor cell-activated nanoconjugates for precise local colorectal cancer therapy

Lee, J., Kim, J., Kwak, D., Kim, H., Ullah, M., Kim, M. C., Hyun, K., Lee, E. H., Yun, H., Jung, Y., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.158935 · Cited by 8

Increased survival rate of selected probiotics under environmental stresses through encapsulation in α-glucan-coated porous starch granules

Kwon, T.-E., Kim, D., Seo, D., Hamaker, B. R., & Yoo, S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140754 · Cited by 8

Design and characterization of lipid nanocarriers for oral delivery of immunotherapeutic peptides

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Natural Nanoparticles in Gegen–Qinlian Decoction Promote the Colonic Absorption of Active Constituents in Mice with Dextran Sulfate Sodium-Induced Ulcerative Colitis

Mu, S., Zheng, Z.-J., Lu, J., Pan, L., & Ma, B. (2025) · Pharmaceuticals · doi:10.3390/ph18111718 · Cited by 7

MUCOADHESIVE POLYMERS IN COLON TARGETED DRUG DELIVERY SYSTEMS: A COMPREHENSIVE REVIEW

Ghodratı, A. D., & Çomoğlu, T. (2024) · Ankara Universitesi Eczacilik Fakultesi Dergisi · doi:10.33483/jfpau.1400920 · Cited by 7

Nanocarriers for cancer-targeted delivery based on Pickering emulsions stabilized by casein nanoparticles

Ben‐Haim, A. E., Shalev, N., Amalraj, A. J. J., Zelinger, E., Mani, K. A., Belausov, E., Shoval, I., Nativ‐Roth, E., Maria, R., Atkins, A., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140822 · Cited by 7

Chitosan Oligosaccharide Modified Bovine Serum Albumin Nanoparticles for Improving Oral Bioavailability of Naringenin

Fang, R., Liao, Y., Qiu, H., Liu, Y., Lin, S., & Chen, H. (2023) · Current Drug Delivery · doi:10.2174/1567201820666230718143726 · Cited by 7

Liver-Targeted Nanoparticles Loaded with Cannabidiol Based on Redox Response for Effective Alleviation of Acute Liver Injury

Zhang, X., Yi, X., Gao, X., Li, Y., & Shen, X. (2024) · Foods · doi:10.3390/foods13152464 · Cited by 6

Progress in construction and release of natural polysaccharide-platinum nanomedicines: A review

Wang, P., Yang, Y., Wen, H., Li, D., Zhang, H., & Wang, Y. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126143 · Cited by 6

Co-delivery of 5-fluorouracil and oxali-palladium via β-lactoglobulin nano-capsules coated with Low Methoxyl Pectin for colon cancer therapy

Leilabadi-Asl, A., Ghalandari, B., Divsalar, A., Karizak, A. Z., Haertlé, T., Ding, X., Saboury, A. A., & Ghorbani, F. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105010 · Cited by 6

An enhanced bioactive chitosan-modified microemulsion for mucosal healing of ulcerative colitis

Yue, L., Ye, P., Zhang, Y., Guo, R., Xu, W., Huang, S., Xiu, Y., Huang, Y., & Wang, B. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137847 · Cited by 6

Hydroxypropyl trimethyl ammonium chloride chitosan (HACC)-modified protein nanoparticles enhance docetaxel oral delivery and exhibit potent in vitro anti-tumor and macrophage-activating effects

Ding, D., Ye, D., Pan, L., Zheng, Z.-J., Xu, Y., Xu, X., Zheng, M., Wang, T.-M., Zhao, Q. S., & Ma, B. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141375 · Cited by 6

Revolutionizing colon-targeted drug delivery: The pivotal role of lipid nano-carriers and their transformative modifications

Willie, Y. B. A., Gunawan, M., Hadad, Y., Ramadon, D., Saputri, F. C., Jansook, P., Boonkanokwong, V., & Iswandana, R. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107319 · Cited by 7

Colon-targeted drug delivery systems through electrospun core–shell nanofiber loaded with camptothecin for the treatment of colorectal cancer

Zhao, Y., Ma, X., Xu, H., Han, L., Zou, M., Wen, Q., & Zhou, J. (2025) · International Journal of Polymeric Materials · doi:10.1080/00914037.2025.2477159 · Cited by 5

Polymeric Micelles in Colorectal Cancer Therapy: A Comprehensive Review of Nano-drug Delivery Strategies, Copolymer Types, Physicochemical Characteristics, and Therapeutic Applications

Shaikh, R., & Bhattacharya, S. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673306752240726104241 · Cited by 6

pH-sensitive nanoformulation of acetyl-11-keto-beta-boswellic acid (AKBA) as a potential antiproliferative agent in colon adenocarcinoma (in vitro and in vivo)

Al-e-Ahmad, A., Kazemi, S., Daraei, A., Sepidarkish, M., Moghadamnia, A. A., & Parsian, H. (2024) · Cancer Nanotechnology · doi:10.1186/s12645-024-00289-9 · Cited by 5

An Overview of Colon Specific Drug Delivery: Approaches and Evaluation Aspects

Siddiqui, M. A., Agrawal, N., Jaiswal, M., Gupta, S., & Lanjhiyana, S. K. (2025) · Current Drug Research Reviews · doi:10.2174/0125899775364358250124105814 · Cited by 5

Dual-responsive magnetoliposome-stabilized Pickering emulsion alginate hydrogel beads for oral drug delivery

Sia, C. S., Bong, W. A., Goh, B. H., Chong, L. H., Tey, B. T., & Low, L. E. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146291 · Cited by 5

Precision targeted delivery based on PUFAs: Overview, strategies and applications

Zhu, P., Li, J., Zhou, Y., Li, J., & Yu, Q. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145800 · Cited by 5

MAGNETIC NANOPARTICLE-BASED APPROACHES IN CANCER THERAPY–A CRITICAL REVIEW

Karthikeyan, R., Velmurugan, V., Abishek, V., & K., L. (2022) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2022v14i6.45064 · Cited by 5

Clinical applications and future clinical trials of the drug delivery system

Çetin, K., Şarkaya, K., & Deni̇zli̇, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95325-2.00020-1 · Cited by 5

The Emerging Roles of Nano Drug Delivery Systems in Treatment of Osteoporosis-Current Knowledge, Challenges and Future Perspectives

Yin, P., Dong, S., Yu, J., Zhao, Z., & Hu, Y. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s539879 · Cited by 4

Structural and temporal dynamics of nano-based therapies in ulcerative colitis: history, hotspots, and emerging trends

Shi, J., Cui, D., Yu, L., & Gong, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1739037 · Cited by 4

Polymer for Biomedical Applications

Riasat, I., Naeem, M., Khan, M. U. A., Jamal, S. B., Khalil, A. A. K., Haider, S., & Haider, A. (2022) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-030-84977-1_15 · Cited by 4

From Prodrug to Multimatrix: Recent Advancement of Colon Specific Drug Delivery System

Saha, S. K., Hasan, A. H. M. N., Anjum, R., Rimun, S. N., Rahman, N. Z., Akanda, M. K. M., Buhiyan, M. A., & Islam, S. M. A. (2024) · Sciences of Pharmacy · doi:10.58920/sciphar0303233 · Cited by 4

Application of Nanobubble-Based Ultrasound Combined with General Anesthesia for the Treatment of Colon Cancer Patients

Qiu, Y., Li, Y., & Fan, C. (2021) · Science of Advanced Materials · doi:10.1166/sam.2021.4046 · Cited by 4

Preparation and properties of tumor-targeting lentinan-oleic acid polymer micelles based on folic acid for adriamycin delivery

Yang, Y., Song, Z., Qi, W., Zhang, N.-N., Gao, Y., Jin, L., Zhang, A., & Song, Y. (2023) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2023.105717 · Cited by 4

Role of Nano Enzyme in Diagnosis, Prognosis and Treatment of Gastrointestinal Tract (GIT) Cancer

Shuja, A., Abubakar, M., Shahbaz, M. N., Shahid, S., & Mukhtiar, M. (2024) · Developmental medico-life-sciences · doi:10.69750/dmls.01.01.015 · Cited by 4

Advances and prospects of microenvironment-targeted nanotherapeutics for ulcerative colitis: evolving paradigms in the precision gut microenvironment

Lu, H., Zhang, W., Wu, Z., Peng, Y., Liu, F., Gao, S., & Deng, L. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126546 · Cited by 3

Colon-responsive targeted drug delivery for treating colonic disorder

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