Cited by 248Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryDrug Solubulity and Delivery Systems

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Advances in colon-targeted nano-drug delivery systems: challenges and solutions

Naeem, Muhammad, Awan, Uzma Azeem, Subhan, Fazli, Cao, Jiafu, Hlaing, Shwe Phyu, Lee, Juho, Im, Eunok, Jung, Yunjin, Yoo, Jin-Wook·2020·Archives of Pharmacal Research

DOI 10.1007/s12272-020-01219-0

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Abstract

Nano-drug delivery systems (NDDS) for colon-targeted drug delivery are an active area of research on local diseases affecting the colon, such as ulcerative colitis, Crohn's disease, colon cancer, and for the delivery of peptide or protein drugs and vaccinations. In particular, targeted nano-drug delivery to the colon is advantageous for colon-specific diseases because nanoparticles can accumulate in diseased parts, improve the efficacies of therapeutics, and enable localized treatments, which reduces systemic toxicity. However, there are many hurdles, such as burst drug release, enzyme and acidic degradation of drug and carrier in the stomach, pH variations, mucus entrapment, and systemic uptake in the upper small intestine, which could challenge and compromise the successful delivery of NDDS to the colon. With advancements in NDDS, it may be possible to overcome these challenges leading to efficient drug delivery for colon-specific disorders. This review describes a few of the potential colon-specific drug delivery areas and the challenges faced by colon-targeted orally administered delivery systems, and provides an updated summary of recent advances in the development of orally administered NDDS for colon targeting, and the future advances in this research.

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Authors: Naeem, M., Awan, U. A., Subhan, F., Cao, J., Hlaing, S. P., Lee, J., Im, E., Jung, Y., & Yoo, J.-W.
Affiliations: National University of Medical Sciences (PK)
Pusan National University (KR)
Corresponding author: Yoo, Jin-Wook
ORCID: Awan, Uzma Azeem
Subhan, Fazli
Cao, Jiafu
Hlaing, Shwe Phyu
Lee, Juho
Im, Eunok
Jung, Yunjin
Yoo, Jin-Wook
Venue: Archives of Pharmacal Research
Publisher: Springer Science and Business Media LLC
Published: 2020-01
Volume: 43
Issue: 1
Pages: 153-169
ISSN: 0253-6269 (ISSN-L)
1976-3786
DOI: 10.1007/s12272-020-01219-0
OpenAlex: W3000884526
Cited by: 248
References: 138
Citations by year: 2026: 22 · 2025: 57 · 2024: 44 · 2023: 50 · 2022: 40 · 2021: 20 · 2020: 14
FWCI: 2.70
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Archives of Pharmacal Research (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education (NRF-2019R1I1A3A01057849)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords: colon-targeted drug delivery, nanoparticle drug delivery, oral drug delivery, gastrointestinal pH, enzyme degradation, ulcerative colitis, Crohn's disease, colon cancer
MeSH terms: Animals, Colonic Diseases, Drug Carriers, Humans, Hydrogen-Ion Concentration, Drug Delivery Systems, Nanoparticles, Drug Liberation

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