The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Nano-graphene oxide for cellular imaging and drug delivery
Open accessAbstract
Two-dimensional graphene offers interesting electronic, thermal, and mechanical properties that are currently being explored for advanced electronics, membranes, and composites. Here we synthesize and explore the biological applications of nano-graphene oxide (NGO), i.e., single-layer graphene oxide sheets down to a few nanometers in lateral width. We develop functionalization chemistry in order to impart solubility and compatibility of NGO in biological environments. We obtain size separated pegylated NGO sheets that are soluble in buffers and serum without agglomeration. The NGO sheets are found to be photoluminescent in the visible and infrared regions. The intrinsic photoluminescence (PL) of NGO is used for live cell imaging in the near-infrared (NIR) with little background. We found that simple physisorption via pi-stacking can be used for loading doxorubicin, a widely used cancer drug onto NGO functionalized with antibody for selective killing of cancer cells in vitro. Owing to its small size, intrinsic optical properties, large specific surface area, low cost, and useful non-covalent interactions with aromatic drug molecules, NGO is a promising new material for biological and medical applications.
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Cites
Geim, A. K., & Novoselov, K. S. (2007) · Nature Materials · doi:10.1038/nmat1849 · Cited by 39,979
Graphene-based composite materials
Stankovich, S., Dikin, D. A., Dommett, G. H. B., Kohlhaas, K. M., Zimney, E. J., Stach, E. A., Piner, R. D., Nguyen, S. T., & Ruoff, R. S. (2006) · Nature · doi:10.1038/nature04969 · Cited by 12,922
Cited by
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Ni(OH) 2 Nanoplates Grown on Graphene as Advanced Electrochemical Pseudocapacitor Materials
Wang, H., Casalongue, H. S., Liang, Y., & Dai, H. (2010) · Journal of the American Chemical Society · doi:10.1021/ja102267j · Cited by 2,042
Self-citationMn3O4−Graphene Hybrid as a High-Capacity Anode Material for Lithium Ion Batteries
Wang, H., Cui, L.-F., Yang, Y., Sanchez Casalongue, H., Robinson, J. T., Liang, Y., Cui, Y., & Dai, H. (2010) · Journal of the American Chemical Society · doi:10.1021/ja105296a · Cited by 1,948
Self-citationBiju, V. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60273g · Cited by 1,186
Jahan, M., Liu, Z., & Loh, K. P. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201300510 · Cited by 1,016
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Metadata
- Authors
- Sun, X., Liu, Z., Welsher, K., Robinson, J. T., Goodwin, A., Zaric, S., & Dai, H.
- Venue
- Nano Research
- Publisher
- Tsinghua University Press
- Published
- 2008-08-08
- Volume
- 1
- Issue
- 3
- Pages
- 203-212
- ISSN
- 1998-0000 (ISSN-L)
- 1998-0124
- OpenAlex
- W1989037178
- Cited by
- 3,291
- References
- 2
- FWCI
- 49.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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