The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A functionalized graphene oxide-iron oxide nanocomposite for magnetically targeted drug delivery, photothermal therapy, and magnetic resonance imaging
Abstract
Two-dimensional graphene and its composite nanomaterials offer interesting physical/chemical properties and have been extensively explored in a wide range of fields in recent years. In this work, we synthesize a multi-functional superparamagnetic graphene oxide-iron oxide hybrid nanocomposite (GO-IONP), which is then functionalized by a biocompatible polyethylene glycol (PEG) polymer to acquire high stability in physiological solutions. A chemotherapy drug, doxorubicin (DOX), was loaded onto GO-IONP-PEG, forming a GO-IONP-PEG-DOX complex, which enables magnetically targeted drug delivery. GO-IONP-PEG also exhibits strong optical absorbance from the visible to the near-infrared (NIR) region, and can be utilized for localized photothermal ablation of cancer cells guided by the magnetic field. Moreover, for the first time, in vivo magnetic resonance (MR) imaging of tumor-bearing mice is also demonstrated using GO-IONP-PEG as the T 2 contrast agent. Our work suggests the promise of using multifunctional GO-based nanocomposites for applications in cancer theranostics.
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Cites
Superior Thermal Conductivity of Single-Layer Graphene
Balandin, A. A., Ghosh, S., Bao, W., Calizo, I., Teweldebrhan, D., Miao, F., & Lau, C. N. (2008) · Nano Letters · doi:10.1021/nl0731872 · Cited by 13,823
Experimental observation of the quantum Hall effect and Berry's phase in graphene
Zhang, Y., Tan, Y.-W., Stormer, H. L., & Kim, P. (2005) · Nature · doi:10.1038/nature04235 · Cited by 13,435
Xu, H., Cheng, L., Wang, C., Ma, X., Li, Y., & Liu, Z. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.053 · Cited by 301
Cited by
Nano-graphene in biomedicine: theranostic applications
Yang, K., Feng, L., Shi, X., & Liu, Z. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35342c · Cited by 1,634
Self-citationGraphene-based nanomaterials for drug delivery and tissue engineering
Goenka, S., Sant, V., & Sant, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.017 · Cited by 1,311
New Horizons for Diagnostics and Therapeutic Applications of Graphene and Graphene Oxide
Feng, L., Wu, L., & Qu, X. (2013) · Advanced Materials · doi:10.1002/adma.201203229 · Cited by 632
Self-citationNanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery
Panwar, N., Soehartono, A. M., Chan, K. K., Zeng, S., Xu, G., Qu, J., Coquet, P., Yong, K.-T., & Chen, X. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00099 · Cited by 555
Liang, C., Xu, L., Song, G., & Liu, Z. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00458j · Cited by 435
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Metadata
- Authors
- Ma, X., Tao, H., Yang, K., Feng, L., Cheng, L., Shi, X., Li, Y., Guo, L., & Liu, Z.
- Venue
- Nano Research
- Publisher
- Tsinghua University Press
- Published
- 2012-02-11
- Volume
- 5
- Issue
- 3
- Pages
- 199-212
- ISSN
- 1998-0000 (ISSN-L)
- 1998-0124
- OpenAlex
- W2026972453
- Cited by
- 614
- References
- 3
- FWCI
- 27.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ma, X., Tao, H., Yang, K., Feng, L., Cheng, L., Shi, X., Li, Y., Guo, L., & Liu, Z. (2012). A functionalized graphene oxide-iron oxide nanocomposite for magnetically targeted drug delivery, photothermal therapy, and magnetic resonance imaging. Nano Research. https://doi.org/10.1007/s12274-012-0200-y
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