Cited by 301Luminescence Properties of Advanced MaterialsNanoplatforms for cancer theranosticsNanoparticle-Based Drug Delivery

Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery

Xu, Huan, Cheng, Liang, Wang, Chao, Ma, Xinxing, Li, Yonggang, Liu, Zhuang·2011·Biomaterials

Abstract

Multimodal imaging and imaging-guided therapies have become a new trend in the current development of cancer theranostics. In this work, we encapsulate hydrophobic upconversion nanoparticles (UCNPs) together with iron oxide nanoparticles (IONPs) by using an amphiphilic block copolymer, poly (styrene-block-allyl alcohol) (PS(16)-b-PAA(10)), via a microemulsion method, obtaining an UC-IO@Polymer multi-functional nanocomposite system. Fluorescent dye and anti-cancer drug molecules can be further loaded inside the UC-IO@Polymer nanocomposite for additional functionalities. Utilizing the Squaraine (SQ) dye loaded nanocomposite (UC-IO@Polymer-SQ), triple-modal upconversion luminescence (UCL)/down-conversion fluorescence (FL)/magnetic resonance (MR) imaging is demonstrated in vitro and in vivo, and also applied for in vivo cancer cell tracking in mice. On the other hand, a chemotherapy drug, doxorubicin, is also loaded into the nanocomposite, forming an UC-IO@Polymer-DOX complex, which enables novel imaging-guided and magnetic targeted drug delivery. Our work provides a method to fabricate a nanocomposite system with highly integrated functionalities for multimodal biomedical imaging and cancer therapy.

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Crossref · 10.1016/j.biomaterials.2011.08.053

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  • Upon surface modification, superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging, magnetic particle imaging, targeted delivery of drugs, proteins, antibodies and nucleic acids, hyperthermia, biosensing, tissue repair, and separation of biomolecules.

    “Upon surface-modification, the resulting superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging (MRI) [4–8], magnetic particle imaging (MPI) [9–12], targeted delivery of drugs, proteins, antibodies, and nucleic acids [6, 7, 13, 14], hyperthermia [15–17], biosensing [18], tissue repair [19], and separation of biomolecules [20].”

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Authors
Xu, H., Cheng, L., Wang, C., Ma, X., Li, Y., & Liu, Z.
Affiliations
  • Soochow University (CN)
  • First Affiliated Hospital of Soochow University (CN)
Corresponding author
  • Li, Yonggang
  • Liu, Zhuang
Venue
Biomaterials
Publisher
Elsevier BV
Published
2011-12
Volume
32
Issue
35
Pages
9364-9373
ISSN
0142-9612 (ISSN-L)
OpenAlex
W1964991943
Cited by
301
References
33
Citations by year
2026: 5 · 2025: 8 · 2024: 9 · 2023: 14 · 2022: 17 · 2021: 20 · 2020: 13 · 2019: 18 · 2018: 24 · 2017: 30 · 2016: 21 · 2015: 27 · 2014: 28 · 2013: 34 · 2012: 32
FWCI
14.90
Type
journal article
Language
en
Open access
closed
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • Soochow University
  • Specialized Research Fund for the Doctoral Program of Higher Education of China
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
upconversion nanoparticles, iron oxide nanoparticles, polymer nanocomposites, amphiphilic block copolymers, microemulsion polymerization, multimodal imaging, upconversion luminescence, magnetic resonance imaging, squaraine dyes, doxorubicin, cancer theranostics, tumor cell tracking, image-guided therapy
MeSH terms
Animals, Doxorubicin, Ferric Compounds, Fluorescence, Humans, Injections, Intravenous, Magnetic Resonance Spectroscopy, Polymers, Drug Delivery Systems, Imaging, Three-Dimensional, Cell Line, Tumor, Mice, Nanoparticles, Nanocomposites

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