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Cited by 17

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Transcriptional regulation of hemO encoding heme oxygenase in Clostridium perfringens

Hassan, Sufi, Ohtani, Kaori, Wang, Ruoyu, Yuan, Yonghui, Wang, Yun, Yamaguchi, Yumi, Shimizu, Tohru·2010·The Journal of Microbiology
DOI 10.1007/s12275-009-0384-3
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Abstract

A Gram-positive anaerobic pathogen, Clostridium perfringens, causes clostridial myonecrosis or gas gangrene in humans by producing numerous extracellular toxins and enzymes that act in concert to degrade host tissues. The ability of infectious bacteria to acquire sufficient iron during infection is essential for the pathogen to cause disease. In the C. perfringens strain 13 genome, a heme oxygenase gene homologue (CPE0214, hemO) was found and its role was examined. The purified recombinant HemO protein showed heme oxygenase activity that can convert heme to biliverdin. hemO transcription was induced in response to extracellular hemin in a dose-dependent manner. The global two-component VirR/VirS regulatory system and its secondary regulator VR-RNA had positive regulatory effects on the transcription of hemO. These data indicate that heme oxygenase may play important roles in iron acquisition and cellular metabolism, and that the VirR/VirS-VR-RNA system is also involved in the regulation of cellular iron homeostasis, which might be important for the survival of C. perfringens in a human host.

Overview

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Registry

Crossref · 10.1007/s12275-009-0384-3

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

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Citations

Cites

Cited by

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Metadata

Authors
Hassan, S., Ohtani, K., Wang, R., Yuan, Y., Wang, Y., Yamaguchi, Y., & Shimizu, T.
Venue
The Journal of Microbiology
Publisher
The Microbiological Society of Korea
Published
2010-02
Volume
48
Issue
1
Pages
96-101
ISSN
  • 1225-8873
  • 1976-3794
DOI
10.1007/s12275-009-0384-3
Cited by
17
References
26
Language
en
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.