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Cited by 20Attention Deficit Hyperactivity DisorderPrenatal Substance Exposure EffectsSmoking Behavior and Cessation

Maternal smoking during pregnancy and offspring attention-deficit/hyperactivity disorder: a case-control study in Japan

The Wakayama ADHD Study Group, Yoshimasu, Kouichi, Kiyohara, Chikako, Minami, Takaomi, Yoshikawa, Norishige, Kihira, Shogo, Toyonaga, Koji, Yamamoto, Akira +3 more·2009·ADHD Attention Deficit and Hyperactivity Disorders
DOI 10.1007/s12402-009-0015-1
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Abstract

Although maternal smoking during pregnancy has been shown to be associated with an increased risk of offspring attention-deficit/hyperactivity disorder (ADHD) in Western countries, there is no empirical evidence in non-Caucasian. Purpose of the present study is to examine the relationship between maternal smoking during pregnancy and offspring ADHD in Japanese population. A case-control study design was adopted. A total of 90 pairs of children with ADHD and mothers as well as 270 corresponding control pairs were recruited throughout the study period. A psychiatrist interviewed all the mothers of children with ADHD and control children and elicited information regarding their lifestyles during pregnancy, including active and passive smoking or drinking habits, as well as psychosocial and perinatal factors. Diagnosis of ADHD was made by each physician in charge according to DSM-IV diagnostic criteria. Logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI) with adjustments for other possible confounding factors. Maternal active smoking during pregnancy was associated with an approximately twofold increased risk of offspring ADHD, even after adjusting for socioeconomic and perinatal confounding factors (OR 1.8 95% CI 0.9-3.6). However, the association was obviously attenuated when factors regarding parental psychopathological vulnerability were controlled (OR 1.3 95% CI 0.6-2.9). On the other hand, maternal passive smoking during pregnancy failed to show any material association with ADHD. These results suggested that a significant part of the association between maternal smoking during pregnancy, and ADHD might be explained by genetic factors including parental psychopathological vulnerability.

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  • Prenatal and perinatal factors including maternal alcohol consumption and smoking, maternal stress, and low birth weight and prematurity are frequently associated with ADHD.

    “Prenatal and perinatal factors, including maternal alcohol consumption and smoking (Yoshimasu et al., 2009; Silva et al., 2014; Schwenke et al., 2018), maternal stress (Grizenko et al., 2008; Van Batenburg-Eddes et al., 2013; Glover, 2014), and low birth weight and prematurity (Mick et al., 2002; Thapar et al., 2013) are frequently associated with ADHD.”

    From A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD) (2019) · cites this paper as Yoshimasu et al., 2009

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Authors
The Wakayama ADHD Study Group, Yoshimasu, K., Kiyohara, C., Minami, T., Yoshikawa, N., Kihira, S., Toyonaga, K., Yamamoto, A., Shinosaki, K., Yamashita, H., & Miyashita, K.
Affiliations
  • Wakayama Medical University (JP)
  • Kyushu University (JP)
  • Osaka City General Hospital (JP)
Corresponding author
Yoshimasu, Kouichi
ORCID
Venue
ADHD Attention Deficit and Hyperactivity Disorders
Publisher
Springer Science and Business Media LLC
Published
2009-11-12
Volume
1
Issue
2
Pages
223-231
ISSN
  • 1866-6116 (ISSN-L)
  • 1866-6647
DOI
10.1007/s12402-009-0015-1
OpenAlex
W2038984714
Cited by
20
References
37
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 2
FWCI
0.82
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • ADHD Attention Deficit and Hyperactivity Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords
smoking during pregnancy, attention deficit hyperactivity disorder, passive smoking, genetic susceptibility, perinatal factors, Japanese population
MeSH terms
Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Child, Female, Humans, Japan, Male, Maternal Behavior, Pregnancy, Prenatal Exposure Delayed Effects, Smoking, Tobacco Smoke Pollution, Reproducibility of Results, Models, Statistical, Odds Ratio, Case-Control Studies, Asian People

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