APOE Genotype Influences Postprandial Blood Pressure After High fat Feeding in Older Adults
Open accessAbstract
OBJECTIVE: Postprandial hypotension (PPH) is a common phenomenon among older adults. The degree to which individuals experience PPH is related to cerebrovascular risk factors and the presence of neurodegenerative diseases such as Alzheimer's disease (AD). Carrier status of the E4 allele of the apolipoprotein E (APOE) gene is a risk factor for AD and influences a variety of responses to metabolic and dietary interventions. However, it is unknown whether APOE genotype influences the risk of PPH and whether type of meal can mediate that response. DESIGN: Acute meal study with a crossover design. PARTICIPANTS: 32 cognitively healthy older adults with (n=18) and without (n=14) E4+ carrier status. INTERVENTION: As a part of an ongoing meal study we examined the postprandial blood pressure response after ingestion of a high carbohydrate (HCM) and high fat meal (HFM). MEASUREMENTS: Blood pressure measurements were taken at 7 time points and change scores, area under the curve (AUC) scores were calculated. Data were analyzed by repeated measures ANOVA as well as Pearson correlation. RESULTS: Both meals produced a sustained drop in systolic (SBP) and diastolic (DBP) blood pressure, with 37.5% of participants meeting criteria for PPH. Participants carrying the E4+ risk gene experienced a larger decrease in SBP than E4- participants, and this was significantly different after the HFM (E4+ AUC = -30.8 ± 7.6, E4- AUC = -0.2 ± 8.7, p=0.015). Increasing age was associated with a larger drop in postprandial blood pressure but only for the E4+ group after the HFM (p=0.002). CONCLUSIONS: These data suggest that E4+ individuals experience a greater postprandial blood pressure response particularly following high fat feeding, and this effect becomes more pronounced with age. The prevalence of PPH may play a role in the development of AD and may be mediated by diet.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Higher diastolic blood pressure has been observed in some cohorts.
“Diastolic blood pressure was elevated for male APOE4 carriers relative to non-carriers, consistent with a documented susceptibility of APOE4 carriers to cardiovascular risk factors [54], including higher diastolic blood pressure observed in some cohorts [55–57].”
From Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status (2024) · cites this paper as [56]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Gauthier, S. G., Reisberg, ., Zaudig, M., Petersen, R. C., Ritchie, K. A., Broich, K., Belleville, S., Brodaty, H., Bennett, D. A., Chertkow, H. M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68542-5 · Cited by 3,920 · see citing works
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Liu, C.-C., Kanekiyo, T., Xu, H., & Bu, G. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.263 · Cited by 3,459 · see citing works
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920 · see citing works
Microvascular injury and blood–brain barrier leakage in Alzheimer's disease
Zipser, B. D., Johanson, C. E., Gonzalez, L., Berzin, T. M., Tavares, R., Hulette, C. M., Vitek, M. P., Hovanesian, V., & Stopa, E. G. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.016 · Cited by 487 · see citing works
Postprandial Hypotension: Epidemiology, Pathophysiology, and Clinical Management
Jansen, R. W. M. M., & Lipsitz, L. A. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-4-199502150-00009 · Cited by 406 · see citing works
Soininen, H., Solomon, A., Visser, P. J., Hendrix, S. B., Blennow, K., Kivipelto, M., Hartmann, T., Hallikainen, I., Hallikainen, M., Helisalmi, S., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30332-0 · Cited by 241 · see citing works
The role of APOE in cerebrovascular dysfunction
Tai, L. M., Thomas, R., Marottoli, F. M., Koster, K. P., Kanekiyo, T., Morris, A. W. J., & Bu, G. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1547-z · Cited by 231 · see citing works
Prudent diet may attenuate the adverse effects of Western diet on cognitive decline
Shakersain, B., Santoni, G., Larsson, S. C., Irving, G. F., Fastbom, J., Fratiglioni, L., & Xu, W. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.08.002 · Cited by 159 · see citing works
Luciano, G. L., Brennan, M. J., & Rothberg, M. B. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.06.026 · Cited by 138 · see citing works
Puisieux, F. L., Bulckaen, H., Fauchais, A. L., et al. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.9.m535 · Cited by 104 · see citing works
Risk factors for vascular dementia: Hypotension as a key point
Moretti, R. (2008) · Vascular Health and Risk Management · doi:10.2147/vhrm.s2434 · Cited by 102 · see citing works
Greasing the wheels of Aβ clearance in Alzheimer's Disease: The role of lipids and apolipoprotein E
Fan, J., Donkin, J., & Wellington, C. (2009) · BioFactors · doi:10.1002/biof.37 · Cited by 97 · see citing works
Amyloid-β Pathology and APOE Genotype Modulate Retinoid X Receptor Agonist Activity in Vivo
Tai, L. M., Koster, K. P., Luo, J., Lee, S., Wang, Y., Collins, N. C., Aissa, M. B., Thatcher, G. R. J., & LaDu, M. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.600833 · Cited by 93 · see citing works
Potter, J. F., Heseltine, D., Hartley, G., Matthews, J., Macdonald, I. A., & James, O. F. W. (1989) · Clinical Science · doi:10.1042/cs0770265 · Cited by 90 · see citing works
Apolipoprotein E, Amyloid-β, and Blood-Brain Barrier Permeability in Alzheimer Disease
Donahue, J. E., & Johanson, C. E. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31816a0dc8 · Cited by 86 · see citing works
ApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children
Oriá, R. B., Patrick, P. D., Oriá, M. O. B., Lorntz, B., Thompson, M. R., de Azevedo, O. G. R., Lôbo, R. N. B., Pinkerton, R., Guerrant, R. L., & Lima, A. Â. M. (2010) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2010007500003 · Cited by 81 · see citing works
Postprandial hypotension in neurological disorders: systematic review and meta-analysis
Pavelić, A. R., Skorić, M. K., Crnošija, L., et al. (2017) · Clinical Autonomic Research · doi:10.1007/s10286-017-0440-8 · Cited by 55 · see citing works
Mathias, C. J., Costa, D., McIntosh, C. M., Fosbraey, P., Bannister, R., Wood, S. M., Bloom, S. R., & Christensen, N. J. (1989) · Clinical Science · doi:10.1042/cs0770085 · Cited by 51 · see citing works
Cardiovascular responses to a high-fat and a high-carbohydrate meal in healthy elderly subjects
Sidery, M. B., Cowley, A. J., & Macdonald, I. A. (1993) · Clinical Science · doi:10.1042/cs0840263 · Cited by 50 · see citing works
Vloet, L. C. M., Mehagnoul‐Schipper, D. J., Hoefnagels, W. H. L., et al. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.12.m744 · Cited by 50 · see citing works
Gentilcore, D., Hausken, T., Meyer, J. H., Chapman, I. M., Horowitz, M., & Jones, K. L. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.156 · Cited by 49 · see citing works
Kuipers, H. M., Jansen, R. W. M. M., Peeters, T. L., et al. (1991) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1991.tb01623.x · Cited by 48 · see citing works
Hanson, A. J., Bayer, J. L., Baker, L. D., Cholerton, B., VanFossen, B. T., Trittschuh, E. H., Rissman, R. A., Donohue, M., Moghadam, S. H., Plymate, S. R., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150273 · Cited by 47 · see citing works
Self-citationThe course of blood pressure after a meal: a difference between young and elderly subjects.
Westenend, M., Lenders, J. W. M., & Thien, T. B. (1985) · PubMed · Cited by 33 · see citing works
Hypotensive Syndromes Are Not Associated With Cognitive Impairment in Geriatric Patients
Schoon, Y., Lagró, J., Verhoeven, Y., Rikkert, M. G. M. O., & Claassen, J. A. H. R. (2012) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317512466692 · Cited by 31 · see citing works
Antihypertensive Treatment and Postprandial Blood Pressure Reduction in the Elderly
Jansen, R. W. M. M., Lenders, J. W. M., Thien, T. B., et al. (2009) · Gerontology · doi:10.1159/000212904 · Cited by 21 · see citing works
Postprandial hypotension in Alzheimer's disease
Idiaquez, J. F., Rios, L., & Sandoval, E. (1997) · Clinical Autonomic Research · doi:10.1007/bf02308837 · Cited by 18 · see citing works
Hanson, A. J., Banks, W. A., Saucedo, H. H., & Craft, S. (2016) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000444079 · Cited by 17 · see citing works
Self-citationLupattelli, G., Pisciotta, L., VUONO, S. D., Siepi, D., Bellocchio, A., Melis, F., Bertolini, S., Pirro, M., & Mannarino, E. (2012) · Journal of clinical lipidology · doi:10.1016/j.jacl.2012.12.003 · Cited by 13 · see citing works
Nutrient stimulation of mesenteric blood flow - implications for older critically ill patients
Nguyen, T. A., Abdelhamid, Y. A., Phillips, L. K., Chapple, L. S., Horowitz, M., Jones, K. L., & Deane, A. M. (2017) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v6.i1.28 · Cited by 10 · see citing works
Postprandial hypotension in the elderly: Findings in a Mexican population
Asensio, E., Alvarez, J. B., Lara, S., et al. (2015) · Archivos de cardiología de México · doi:10.1016/j.acmx.2015.05.002 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Reas, E. T., Triebswetter, C., Banks, S. J., & McEvoy, L. K. (2024) · Alzheimer's Research & Therapy · doi:10.1186/s13195-023-01380-w · Cited by 20 · see citing works
- Authors
- Stewart, K. C., Subramanian, D., Neal, U. J., & Hanson, A. J.
- Affiliations
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- Corresponding author
- Hanson, Angela J.
- ORCID
- Hanson, Angela J.
- Venue
- The Journal of nutrition, health and aging
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 23
- Issue
- 5
- Pages
- 408-413
- ISSN
- 1279-7707 (ISSN-L)
- PMC
- PMC6544369
- OpenAlex
- W2922964290
- Cited by
- 3
- References
- 31
- Citations by year
- 2025: 1 · 2024: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The journal of nutrition health & aging (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (K23AG047978)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- postprandial hypotension, apolipoprotein E, APOE ε4, high-fat meal, postprandial blood pressure, older adults, Alzheimer's disease risk, age effects, high-carbohydrate meal
- MeSH terms
- Aged, Aged, 80 and over, Apolipoproteins E, Blood Pressure, Female, Genotype, Humans, Hypotension, Male, Middle Aged, Postprandial Period, Diet, High-Fat, Meals, Healthy Volunteers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
