Anti-amnestic Effect of Curcumin in Combination with Donepezil, an Anticholinesterase Drug: Involvement of Cholinergic System
Abstract
Recently, combination therapy involving cholinesterase (ChE) inhibitor with other neuroprotective agents has shown better desirable effect in the management/prevention of dementia but limited information is available on their effect with dietary polyphenols. Hence, this study sought to assess the combined pretreatment effect of curcumin, the major polyphenolic compound of turmeric (Curcuma longa) rhizomes, with donepezil, a cholinesterase inhibitor, on cognitive function in scopolamine-induced memory impairment in rats. Rats were pretreated with curcumin (50 mg/kg) and/or donepezil (2.5 mg/kg) via oral administration (p.o.) for seven successive days. Dementia was induced at the end of the treatment period by a single injection of scopolamine (1 mg/kg) via intraperitoneal (i.p.) administration. Thereafter, the changes in spatial and episodic memory were conducted; then, the estimation of some biochemical parameters associated with cognitive function was determined. Scopolamine-treated rats showed impaired learning and memory and increased activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), adenosine deaminase (ADA), and lipid peroxidation with a concomitant decreased in levels of nitric oxide (NO) and reduced glutathione (GSH), superoxide dismutase (SOD), and catalase activities when compared with control. However, combination of curcumin and donepezil improves learning and memory activity associated with inhibitory effect on AChE, BuChE, and ADA activities as compared to control. In addition, combined pretreatment significantly decreased lipid peroxidation and increased levels of NO and antioxidant status when compared with scopolamine-treated rats. This finding supports the concept that the combination strategy might be an alternative therapy in the management/prevention of neurological disorders. Thus, the observed anti-amnestic effect could be linked to their inhibitory effect on key enzyme of cholinergic system associated with memory function.
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Coadministration of curcumin and donepezil has a synergistic effect on cognition and oxidative stress.
“coadministration of curcumin and donepezil (reversible cholinesterase inhibitor) had a synergistic effect on cognition and oxidative stress [273]”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [273]
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References 58 · Cited by 82
- Authors
- Akinyemi, A. J., Oboh, G., Oyeleye, S. I., & Ogunsuyi, O.
- Affiliations
- Federal University of Technology (NG)
- Corresponding author
- Akinyemi, Ayodele Jacob
- Venue
- Neurotoxicity Research
- Published
- 2017-01-19
- Volume
- 31
- Issue
- 4
- Pages
- 560-569
- ISSN
- 1029-8428 (ISSN-L)
- 1476-3524
- OpenAlex
- W2578838809
- Cited by
- 82
- References
- 58
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 11 · 2023: 11 · 2022: 9 · 2021: 10 · 2020: 13 · 2019: 5 · 2018: 11 · 2017: 1 · 2015: 1
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurotoxicity Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- curcumin, donepezil, cholinesterase inhibitors, scopolamine-induced amnesia, amnesia, cholinergic system, acetylcholinesterase, butyrylcholinesterase, adenosine deaminase, lipid peroxidation, oxidative stress, antioxidant enzymes, nitric oxide, spatial memory, episodic memory, dementia, combination therapy, dietary polyphenols
- MeSH terms
- Donepezil, Adenosine Deaminase, Animals, Brain, Catalase, Cholinesterase Inhibitors, Curcumin, Drug Synergism, Glutathione, Indans, Male, Memory Disorders, Nitric Oxide, Piperidines, Scopolamine, Superoxide Dismutase, Lipid Peroxidation, Maze Learning, Recognition, Psychology, Rats, Cholinergic Neurons
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