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Minocycline Development for Acute Ischemic Stroke
Open accessAbstract
Minocycline, a tetracycline antibiotic, has shown anti-inflammatory, anti-apoptotic, and neuroprotective effects in many models of cerebral ischemia and neurodegenerative disease. Its high penetration of the blood-brain barrier, good safety profile, and delayed therapeutic window make it an ideal candidate for use in stroke. In animal models, minocycline reduced infarct size and improved neurologic outcome when administered acutely, with similar neuroprotective benefits seen following delayed administration. To date, two early phase clinical trials have shown minocycline to be safe and potentially effective in acute ischemic stroke, alone or in combination with tissue plasminogen activator. A large efficacy clinical trial is now needed to confirm previous studies, allow for subgroup analysis, and pinpoint the potential place for minocycline in acute stroke therapy.
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“So far, minocycline has been incorporated into two clinical trials involving ischemic stroke patients, demonstrating that minocycline administration (both alone and in combination with Fibrinolysis) improved neurological functional outcome following stroke (Fagan et al., 2011).”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Fagan et al., 2011
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Metadata
- Authors
- Fagan, S. C., Cronic, L. E., & Hess, D. C.
- Affiliations
- University of Georgia (US)
- Corresponding author
- Fagan, Susan C.
- ORCID
- Hess, David C.
- Venue
- Translational Stroke Research
- Published
- 2011-04-13
- Volume
- 2
- Issue
- 2
- Pages
- 202-208
- ISSN
- 1868-4483 (ISSN-L)
- 1868-601X
- PMC
- PMC3169090
- OpenAlex
- W2019475666
- Cited by
- 100
- References
- 53
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 3 · 2020: 9 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 7 · 2013: 15 · 2012: 10
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Translational Stroke Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS063965, R01NS055728)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- minocycline, acute ischemic stroke, neuroprotection, anti-inflammatory activity, anti-apoptotic effects, blood-brain barrier penetration, infarct size, tissue plasminogen activator, clinical trials, drug development
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