Cited by 102Acute Ischemic Stroke ManagementNeuroprotection in Cerebral IschemiaNeuroinflammation and Neurodegeneration Mechanisms

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Minocycline Development for Acute Ischemic Stroke

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Fagan, Susan C., Cronic, Lydia E., Hess, David C.·2011·Translational Stroke Research

DOI 10.1007/s12975-011-0072-6PMC PMC3169090

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Abstract

Minocycline, a tetracycline antibiotic, has shown anti-inflammatory, anti-apoptotic, and neuroprotective effects in many models of cerebral ischemia and neurodegenerative disease. Its high penetration of the blood-brain barrier, good safety profile, and delayed therapeutic window make it an ideal candidate for use in stroke. In animal models, minocycline reduced infarct size and improved neurologic outcome when administered acutely, with similar neuroprotective benefits seen following delayed administration. To date, two early phase clinical trials have shown minocycline to be safe and potentially effective in acute ischemic stroke, alone or in combination with tissue plasminogen activator. A large efficacy clinical trial is now needed to confirm previous studies, allow for subgroup analysis, and pinpoint the potential place for minocycline in acute stroke therapy.

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Authors: Fagan, S. C., Cronic, L. E., & Hess, D. C.
Affiliations: University of Georgia (US)
Corresponding author: Fagan, Susan C.
ORCID: Hess, David C.
Venue: Translational Stroke Research
Publisher: Springer Science and Business Media LLC
Published: 2011-04-13
Volume: 2
Issue: 2
Pages: 202-208
ISSN: 1868-4483 (ISSN-L)
1868-601X
DOI: 10.1007/s12975-011-0072-6
PMC: PMC3169090
OpenAlex: W2019475666
Cited by: 100
References: 53
Citations by year: 2026: 2 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 3 · 2020: 9 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 7 · 2013: 15 · 2012: 10
FWCI: 8.19
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Translational Stroke Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS063965, R01NS055728)
Topics: Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: minocycline, acute ischemic stroke, neuroprotection, anti-inflammatory activity, anti-apoptotic effects, blood-brain barrier penetration, infarct size, tissue plasminogen activator, clinical trials, drug development

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Minocycline Development for Acute Ischemic Stroke

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