The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
MiR-126 Affects Brain-Heart Interaction after Cerebral Ischemic Stroke
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“MiR-126 expression is significantly decreased in serum and brain after stroke in mice as well as in T2DM patients7, 38, 39.”
From MiR-126 Mediates Brain Endothelial Cell Exosome Treatment–Induced Neurorestorative Effects After Stroke in Type 2 Diabetes Mellitus Mice (2019) · cites this paper as [39]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cardiovascular effects of human insular cortex stimulation
Oppenheimer, S. M., Gelb, A., Girvin, J. P., & Hachinski, V. C. (1992) · Neurology · doi:10.1212/wnl.42.9.1727 · Cited by 1,272
Flagged first, then by citations
Research works printed but not linked: 52
- Koh SH, Park HH. Neurogenesis in stroke recovery. Transl Stroke Res. 2016; doi: 10.1007/s12975-016-0460-z . · DOI
- Cassidy JM, Cramer SC. Spontaneous and therapeutic-induced mechanisms of functional recovery after stroke. Transl Stroke Res. 2016; doi: 10.1007/s12975-016-0467-5 . · DOI · Paper page
- Wira 3rd CR, Rivers E, Martinez-Capolino C, Silver B, Iyer G, Sherwin R, et al. Cardiac complications in acute ischemic stroke. The Western Journal of Emergency Medicine. 2011;12(4):414–20. doi: 10.5811/westjem.2011.2.1765 . · DOI
- Imam YZ, D’Souza A, Malik RA, Shuaib A. Secondary stroke prevention: improving diagnosis and management with newer technologies. Transl Stroke Res. 2016;7(6):458–77. doi: 10.1007/s12975-016-0494-2 . · DOI
- Ergul A, Hafez S, Fouda A, Fagan SC. Impact of comorbidities on acute injury and recovery in preclinical stroke research: focus on hypertension and diabetes. Transl Stroke Res. 2016;7(4):248–60. doi: 10.1007/s12975-016-0464-8 . · DOI
- Ay H, Koroshetz WJ, Benner T, Vangel MG, Melinosky C, Arsava EM, et al. Neuroanatomic correlates of stroke-related myocardial injury. Neurology. 2006;66(9):1325–9. doi: 10.1212/01.wnl.0000206077.13705.6d . · DOI
- Oppenheimer SM. Neurogenic cardiac effects of cerebrovascular disease. Curr Opin Neurol. 1994;7(1):20–4. · DOI
- Ishikawa H, Tajiri N, Vasconcellos J, Kaneko Y, Mimura O, Dezawa M, et al. Ischemic stroke brain sends indirect cell death signals to the heart. Stroke. 2013;44(11):3175–82. doi: 10.1161/STROKEAHA.113.001714 . · DOI
- Gongora-Rivera F, Labreuche J, Jaramillo A, Steg PG, Hauw JJ, Amarenco P. Autopsy prevalence of coronary atherosclerosis in patients with fatal stroke. Stroke. 2007;38(4):1203–10. doi: 10.1161/01.str.0000260091.13729.96 . · DOI
- Tokgozoglu SL, Batur MK, Topcuoglu MA, Saribas O, Kes S, Oto A. Effects of stroke localization on cardiac autonomic balance and sudden death. Stroke. 1999;30(7):1307–11. · DOI
- Swerdel JN, Janevic TM, Kostis WJ, Faiz A, Cosgrove NM, Kostis JB. Association between dehydration and short-term risk of ischemic stroke in patients with atrial fibrillation. Transl Stroke Res. 2016; doi: 10.1007/s12975-016-0471-9 . · DOI
- Rosenzweig S, Carmichael ST. Age-dependent exacerbation of white matter stroke outcomes: a role for oxidative damage and inflammatory mediators. Stroke. 2013;44(9):2579–86. doi: 10.1161/STROKEAHA.113.001796 . · DOI
- Mishra PK, Tyagi N, Kumar M, Tyagi SC. MicroRNAs as a therapeutic target for cardiovascular diseases. J Cell Mol Med. 2009;13(4):778–89. doi: 10.1111/j.1582-4934.2009.00744.x . · DOI
- Schober A, Nazari-Jahantigh M, Wei Y, Bidzhekov K, Gremse F, Grommes J, et al. MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med. 2014;20(4):368–76. doi: 10.1038/nm.3487 . · DOI
- Hsu A, Chen SJ, Chang YS, Chen HC, Chu PH. Systemic approach to identify serum microRNAs as potential biomarkers for acute myocardial infarction. Biomed Res Int. 2014;2014:418628. doi: 10.1155/2014/418628 . · DOI
- Long G, Wang F, Li H, Yin Z, Sandip C, Lou Y, et al. Circulating miR-30a, miR-126 and let-7b as biomarker for ischemic stroke in humans. BMC Neurol. 2013;13:178. doi: 10.1186/1471-2377-13-178 . · DOI
- Wei XJ, Han M, Yang FY, Wei GC, Liang ZG, Yao H, et al. Biological significance of miR-126 expression in atrial fibrillation and heart failure. Braz J Med Biol Res. 2015;48(11):983–9. doi: 10.1590/1414-431X20154590 . · DOI
- Kuraoka M, Furuta T, Matsuwaki T, Omatsu T, Ishii Y, Kyuwa S, et al. Direct experimental occlusion of the distal middle cerebral artery induces high reproducibility of brain ischemia in mice. Experimental animals/Japanese Association for Laboratory Animal Science. 2009;58(1):19–29. · DOI
- Rosell A, Agin V, Rahman M, Morancho A, Ali C, Koistinaho J, et al. Distal occlusion of the middle cerebral artery in mice: are we ready to assess long-term functional outcome? Transl Stroke Res. 2013;4(3):297–307. doi: 10.1007/s12975-012-0234-1 . · DOI
- Claxton S, Kostourou V, Jadeja S, Chambon P, Hodivala-Dilke K, Fruttiger M. Efficient, inducible Cre-recombinase activation in vascular endothelium. Genesis. 2008;46(2):74–80. doi: 10.1002/dvg.20367 . · DOI
- Kuhnert F, Mancuso MR, Hampton J, Stankunas K, Asano T, Chen CZ, et al. Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development. 2008;135(24):3989–93. doi: 10.1242/dev.029736 . · DOI
- Yang XP, Liu YH, Rhaleb NE, Kurihara N, Kim HE, Carretero OA. Echocardiographic assessment of cardiac function in conscious and anesthetized mice. Am J Phys. 1999;277(5 Pt 2):H1967–74.
- Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR. A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab. 1990;10(2):290–3. · DOI
- Xu J, Carretero OA, Liao TD, Peng H, Shesely EG, Xu J, et al. Local angiotensin II aggravates cardiac remodeling in hypertension. Am J Physiol Heart Circ Physiol. 2010;299(5):H1328–38. doi: 10.1152/ajpheart.00538.2010 . · DOI
- Mito S, Ozono R, Oshima T, Yano Y, Watari Y, Yamamoto Y, et al. Myocardial protection against pressure overload in mice lacking Bach1, a transcriptional repressor of heme oxygenase-1. Hypertension. 2008;51(6):1570–7. doi: 10.1161/HYPERTENSIONAHA.107.102566 . · DOI
- Belostotskaya GB, Golovanova TA. Characterization of contracting cardiomyocyte colonies in the primary culture of neonatal rat myocardial cells: a model of in vitro cardiomyogenesis. Cell Cycle. 2014;13(6):910–8. doi: 10.4161/cc.27768 . · DOI
- Cui X, Chopp M, Zacharek A, Ye X, Roberts C, Chen J. Angiopoietin-Tie2 pathway mediates type 2 diabetes induced vascular damage after cerebral stroke. Neurobiol Dis. 2011;43(1):285–92. doi: 10.1016/j.nbd.2011.04.005 . · DOI
- Xu J, Sun Y, Carretero OA, Zhu L, Harding P, Shesely EG, et al. Effects of cardiac overexpression of the angiotensin II type 2 receptor on remodeling and dysfunction in mice post-myocardial infarction. Hypertension. 2014;63(6):1251–9. · DOI
- Chen J, Ning R, Zacharek A, Cui C, Cui X, Yan T, et al. MiR-126 contributes to human umbilical cord blood cell induced Neurorestorative effects after stroke in type-2 diabetic mice. Stem Cells. 2015; doi: 10.1002/stem.2193 . · DOI · Paper page
- Arner E, Mejhert N, Kulyte A, Balwierz PJ, Pachkov M, Cormont M, et al. Adipose tissue microRNAs as regulators of CCL2 production in human obesity. Diabetes. 2012;61(8):1986–93. doi: 10.2337/db11-1508 . · DOI
- Witkowski M, Weithauser A, Tabaraie T, Steffens D, Krankel N, Witkowski M, et al. Micro-RNA-126 reduces the blood thrombogenicity in diabetes mellitus via targeting of tissue factor. Arterioscler Thromb Vasc Biol. 2016; doi: 10.1161/ATVBAHA.115.306094 . · DOI · Paper page
- Harris TA, Yamakuchi M, Ferlito M, Mendell JT, Lowenstein CJ. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci U S A. 2008;105(5):1516–21. doi: 10.1073/pnas.0707493105 . · DOI
- Rauh R, Fischereder M, Spengel FA. Transesophageal echocardiography in patients with focal cerebral ischemia of unknown cause. Stroke. 1996;27(4):691–4. · DOI
- Kim JM, Jung KH, Chu K, Lee ST, Ban J, Moon J, et al. Atherosclerosis-related circulating MicroRNAs as a predictor of stroke recurrence. Transl Stroke Res. 2015;6(3):191–7. doi: 10.1007/s12975-015-0390-1 . · DOI
- Turchinovich A, Samatov TR, Tonevitsky AG, Burwinkel B. Circulating miRNAs: cell-cell communication function? Front Genet. 2013;4:119. doi: 10.3389/fgene.2013.00119 . · DOI
- Peng G, Yuan Y, Wu S, He F, Hu Y, Luo B. MicroRNA let-7e is a potential circulating biomarker of acute stage ischemic stroke. Transl Stroke Res. 2015;6(6):437–45. doi: 10.1007/s12975-015-0422-x . · DOI
- Small EM, Frost RJA, Olson EN. MicroRNAs add a new dimension to cardiovascular disease. Circulation. 2010;121(8):1022–32. doi: 10.1161/CIRCULATIONAHA.109.889048 . · DOI
- Fei L, Zhang J, Niu H, Yuan C, Ma X. Effects of rosuvastatin and MiR-126 on myocardial injury induced by acute myocardial infarction in rats: role of vascular endothelial growth factor a (VEGF-A). Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2016;22:2324–34. doi: 10.12659/MSM.896983 . · DOI
- Olivieri F, Spazzafumo L, Bonafe M, Recchioni R, Prattichizzo F, Marcheselli F, et al. MiR-21-5p and miR-126a-3p levels in plasma and circulating angiogenic cells: relationship with type 2 diabetes complications. Oncotarget. 2015;6(34):35372–82. doi: 10.18632/oncotarget.6164 . · DOI · Paper page
- Chen F, Du Y, Esposito E, Liu Y, Guo S, Wang X, et al. Effects of focal cerebral ischemia on exosomal versus serum miR126. Transl Stroke Res. 2015;6(6):478–84. doi: 10.1007/s12975-015-0429-3 . · DOI
- Long G, Wang F, Duan Q, Chen F, Yang S, Gong W, et al. Human circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction. Int J Biol Sci. 2012;8(6):811–8. doi: 10.7150/ijbs.4439 . · DOI
- Potus F, Ruffenach G, Dahou A, Thebault C, Breuils-Bonnet S, Tremblay E, et al. Downregulation of microRNA-126 contributes to the failing right ventricle in pulmonary arterial hypertension. Circulation. 2015;132(10):932–43. doi: 10.1161/CIRCULATIONAHA.115.016382 . · DOI
- Silvani A, Calandra-Buonaura G, Dampney RA, Cortelli P. Brain-heart interactions: physiology and clinical implications. Philos Trans A Math Phys Eng Sci. 2016;374(2067) doi: 10.1098/rsta.2015.0181 . · DOI
- Daniele O, Caravaglios G, Fierro B, Natale E. Stroke and cardiac arrhythmias. J Stroke Cerebrovasc Dis. 2002;11(1):28–33. doi: 10.1053/jscd.2002.123972 . · DOI
- Liesz A, Kleinschnitz C. Regulatory T cells in post-stroke immune homeostasis. Transl Stroke Res. 2016;7(4):313–21. doi: 10.1007/s12975-016-0465-7 . · DOI
- Atangana E, Schneider UC, Blecharz K, Magrini S, Wagner J, Nieminen-Kelha M, et al. Intravascular inflammation triggers intracerebral activated microglia and contributes to secondary brain injury after experimental subarachnoid hemorrhage (eSAH). Transl Stroke Res. 2016; doi: 10.1007/s12975-016-0485-3 . · DOI
- Ahmad M, Graham SH. Inflammation after stroke: mechanisms and therapeutic approaches. Transl Stroke Res. 2010;1(2):74–84. doi: 10.1007/s12975-010-0023-7 . · DOI
- Yao Y, Tsirka SE. Chemokines and their receptors in intracerebral hemorrhage. Transl Stroke Res. 2012;3(1):70–9. doi: 10.1007/s12975-012-0155-z . · DOI
- Lambert JM, Lopez EF, Lindsey ML. Macrophage roles following myocardial infarction. Int J Cardiol. 2008;130(2):147–58. doi: 10.1016/j.ijcard.2008.04.059 . · DOI
- Mewhort HE, Lipon BD, Svystonyuk DA, Teng G, Guzzardi DG, Silva C, et al. Monocytes increase human cardiac myofibroblast-mediated extracellular matrix remodeling through TGF-beta1. Am J Physiol Heart Circ Physiol. 2016;310(6):H716–24. doi: 10.1152/ajpheart.00309.2015 . · DOI
- Bujak M, Frangogiannis NG. The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res. 2007;74(2):184–95. doi: 10.1016/j.cardiores.2006.10.002 . · DOI
- Liu Y, Zhang J. Nox2 contributes to cardiac fibrosis in diabetic cardiomyopathy in a transforming growth factor-beta dependent manner. Int J Clin Exp Pathol. 2015;8(9):10908–14.
Cited by
Sorted by citations
Venkat, P., Cui, C., Chopp, M., Zacharek, A., Wang, F., Landschoot-Ward, J., Shen, Y., & Chen, J. (2019) · Stroke · doi:10.1161/strokeaha.119.025371 · Cited by 172
Self-citationExtracellular vesicles: New horizons in neurodegeneration
Chen, J., Tian, C., Xiong, X., Yang, Y., & Zhang, J. (2025) · eBioMedicine · doi:10.1016/j.ebiom.2025.105605 · Cited by 53
Self-citation
Metadata
- Authors
- Chen, J., Cui, C., Yang, X., Xu, J., Venkat, P., Zacharek, A., Yu, P., & Chopp, M.
- ORCID
- Chen, Jieli
- Venue
- Translational Stroke Research
- Published
- 2017-01-19
- Volume
- 8
- Issue
- 4
- Pages
- 374-385
- ISSN
- 1868-4483
- 1868-601X
- PMC
- PMC5604242
- Cited by
- 148
- References
- 1
- Language
- en
- Funders
- National Institute of Neurological Disorders and Stroke (R01 NS083078-01A1, R01 NS099030-01)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review