Cited by 1,272Heart Rate Variability and Autonomic ControlVagus Nerve Stimulation ResearchEpilepsy research and treatment

Cardiovascular effects of human insular cortex stimulation

Oppenheimer, Stephen M., Gelb, Adrian, Girvin, John P., Hachinski, Vladimir C.·1992·Neurology

Abstract

Recent investigations indicate a site of cardiac representation within the left insular cortex of the rat. Moreover, the results of lesion studies suggest left-sided insular dominance for sympathetic cardiovascular effects. It is unclear whether similar representation exists within the human insular cortex. Five epileptic patients underwent intraoperative insular stimulation prior to temporal lobectomy for seizure control. On stimulation of the left insular cortex, bradycardia and depressor responses were more frequently produced than tachycardia and pressor effects (p less than 0.005). The converse applied for the right insular cortex. We believe this to be the first demonstration of cardiovascular changes elicitable during insular stimulation in humans, and of lateralization of such responses for a cortical site. In humans, unlike the rat, there appears to be right-sided dominance for sympathetic effects. These findings may be of relevance in predicting the autonomic effects of stroke in humans and in the explanation of sudden unexpected epileptic death.

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Crossref · 10.1212/wnl.42.9.1727

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Authors
Oppenheimer, S. M., Gelb, A., Girvin, J. P., & Hachinski, V. C.
Affiliations
Johns Hopkins University (US)
Venue
Neurology
Published
1992-09
Volume
42
Issue
9
Pages
1727-1727
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
OpenAlex
W2169985903
Cited by
1,272
References
22
Citations by year
2026: 40 · 2025: 31 · 2024: 38 · 2023: 39 · 2022: 47 · 2021: 48 · 2020: 49 · 2019: 64 · 2018: 62 · 2017: 59 · 2016: 63 · 2015: 57 · 2014: 59 · 2013: 50 · 2012: 48
FWCI
6.24
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
Keywords
insula, cardiovascular effects, electrical brain stimulation, bradycardia, tachycardia, hemispheric lateralization, epilepsy, sudden unexpected death in epilepsy
MeSH terms
Adolescent, Adult, Analysis of Variance, Blood Pressure, Cardiovascular Physiological Phenomena, Cerebral Cortex, Craniotomy, Epilepsy, Heart Rate, Humans, Male, Chi-Square Distribution

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