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Cited by 44Natural product bioactivities and synthesisChemotherapy-induced organ toxicity mitigationPhytochemicals and Medicinal Plants

Protective effect of centella triterpene saponins against cyclophosphamide-induced immune and hepatic system dysfunction in rats: its possible mechanisms of action

Duggina, Pragathi, Kalla, Chandra Mouli, Varikasuvu, Seshadri Reddy, Bukke, Suman, Tartte, Vijaya·2015·Journal of Physiology and Biochemistry
DOI 10.1007/s13105-015-0423-y
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Abstract

This study was designed to investigate the protective effects of the centella triterpene saponins (EXT) on cyclophosphamide (CYP)-induced hepatotoxicity and immunosuppression in rats. The phytochemical profile of EXT was analyzed for centella saponins by using high-performance liquid chromatographic (HPLC). Therapeutic efficacy of EXT (250 mg/kg/day p.o) on hematological profile of blood, liver function markers, and cytokine profiles in CYP (10 mg/kg/day p.o)-treated rats. In addition, weights of immune organs (spleen and thymus) and histopathological changes in the liver, intestine, and spleen were also evaluated. The active principles in EXT were identified as madecassoside, asiaticoside, and asiatic acid by HPLC analysis. Upon administration of EXT, enhanced levels of glutamate pyruvate transaminase, alkaline phosphatase, and lipid peroxidation were found reduced while the levels of reduced glutathione and hematological parameters and relative weights of immune organs were restored to normal in CYP-treated rats. The hepatic mRNA level of TNF-α, which was increased during CYP administration, was significantly decreased by the EXT treatment. The decreased levels of mRNA expression of other cytokines like IFN-γ, IL-2, GM-CSF, after CYP treatment, were also found elevated upon administration of the EXT. Histopathological examination of the intestine, liver, and spleen indicated that the extract could attenuate the CYP-induced hepatic and immune organ damage. These results indi…

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Authors
Duggina, P., Kalla, C. M., Varikasuvu, S. R., Bukke, S., & Tartte, V.
Affiliations
  • Sri Venkateswara University (IN)
  • Government of Haryana (IN)
ORCID
Varikasuvu, Seshadri Reddy
Venue
Journal of Physiology and Biochemistry
Publisher
Springer Science and Business Media LLC
Published
2015-07-14
Volume
71
Issue
3
Pages
435-454
ISSN
  • 1138-7548 (ISSN-L)
  • 1877-8755
DOI
10.1007/s13105-015-0423-y
OpenAlex
W885983275
Cited by
44
References
2
Citations by year
2026: 3 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 1 · 2016: 1
FWCI
1.30
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Physiology and Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Keywords
Centella asiatica, triterpenoid saponins, cyclophosphamide, hepatotoxicity, immunosuppression, madecassoside, asiaticoside, asiatic acid, cytokines, TNF-α, interferon-gamma, interleukin-2, GM-CSF, antioxidant defense, glutathione, lipid peroxidation, liver function markers, hepatoprotection, immunomodulation
MeSH terms
Alkaline Phosphatase, Animals, Cyclophosphamide, Drug Evaluation, Preclinical, Erythrocyte Count, Interferon-gamma, Interleukin-2, Intestines, Leukocyte Count, Liver, Male, Organ Size, Plant Extracts, Platelet Count, Saponins, Spleen, Triterpenes, Tumor Necrosis Factor-alpha, Lipid Peroxidation, Gene Expression, Granulocyte-Macrophage Colony-Stimulating Factor, Rats, Wistar, Antineoplastic Agents, Alkylating, Cytoprotection, Centella

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