The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Cevimeline (Evoxac ®) Overdose
Open accessAbstract
Cevimeline (Evoxac ®) is an oral muscarinic agent that has been recently approved for the treatment of xerostomia in the setting of Sjogren's syndrome. Its toxicity in overdose has not been reported in the medical literature to date. We report a previously healthy patient who intentionally ingested approximately 10 mg/kg of cevimeline and presented with symptoms of muscarinic excess and mental status depression. The patient recovered uneventfully after receiving activated charcoal and supportive care. This report describes the first documented cevimeline overdose.
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To our knowledge, there has only been one other documented cevimeline overdose, and that case was not associated with herbal supplementation interaction.
“To our knowledge, there has only been one other documented cevimeline overdose, and that case was not associated with herbal supplementation interaction [9].”
From Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report (2022) · cites this paper as [9]
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Cites
Management of acute organophosphorus pesticide poisoning
Eddleston, M., Buckley, N. A., Eyer, P., & Dawson, A. H. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61202-1 · Cited by 1,189
(2017) · Arzneimittelforschung · doi:10.1055/s-00000175 · Cited by 1,134
Petrone, D., Condemi, J. J., Fife, R. S., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.510 · Cited by 281
Cevimeline for the Treatment of Xerostomia in Patients With Sjögren Syndrome
Fife, R. S., Chase, W. F., Dore, R. K., Wiesenhutter, C. W., Lockhart, P. B., Tindall, E. A., & Suen, J. Y. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.11.1293 · Cited by 192
Bardin, P. G., & van Eeden, S. F. (1990) · PubMed · Cited by 87
Bardin, P. G., & van Eeden, S. F. (1990) · Critical Care Medicine · doi:10.1097/00003246-199009000-00010 · Cited by 80
Pilocarpine toxicity and the treatment of xerostomia
Hendrickson, R. G., Morocco, A. P., & Greenberg, M. I. (2004) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2003.09.013 · Cited by 38
Weber, J., & Keating, G. M. (2008) · Drugs · doi:10.2165/00003495-200868120-00006 · Cited by 33
Arisawa, H., Imai, E., Fujise, N., et al. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1299850 · Cited by 12
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Research works printed but not linked: 2
- Olson K (ed) (2004) Poisoning and drug overdose, 5th edn. McGraw-Hill, New York, pp 415–417
- Howland MA (2006) Antidotes in depth: Atropine. In: Flomenbaum NA (ed) Goldfrank’s toxicological emergencies, 8th edn. McGraw-Hill, New York, pp 1519–1522
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Acquarulo, B., Tandon, P., & Macica, C. M. (2022) · Journal of Medical Case Reports · doi:10.1186/s13256-022-03479-4 · Cited by 8
Metadata
- Authors
- Voskoboynik, B., Babu, K., & Hack, J. B.
- Affiliations
- Brown University (US)
- Corresponding author
- Voskoboynik, Berenika
- Venue
- Journal of Medical Toxicology
- Published
- 2010-09-24
- Volume
- 7
- Issue
- 1
- Pages
- 57-59
- ISSN
- 1556-9039 (ISSN-L)
- 1937-6995
- PMC
- PMC3614114
- OpenAlex
- W1983408331
- Cited by
- 14
- References
- 9
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2018: 1 · 2015: 1 · 2012: 1
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Medical Toxicology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Plant-based Medicinal Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- cevimeline, drug overdose, xerostomia, Sjögren's syndrome, cholinergic toxicity, activated carbon, intentional ingestion
- MeSH terms
- Female, Humans, Middle Aged, Poisoning, Quinuclidines, Thiophenes, Treatment Outcome, Muscarinic Agonists, Drug Overdose
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