The Toxicology Investigators Consortium Case Registry—the 2016 Experience
Open accessAbstract
The Toxicology Investigators Consortium (ToxIC) Case Registry was established by the American College of Medical Toxicology in 2010. The Registry contains data from participating sites with the agreement that all bedside medical toxicology consultations will be entered. Currently, 83% of accredited medical toxicology fellowship programs in the USA participate. The Registry continues to grow each year, and as of 31 December 2016, a new milestone was reached, with more than 50,000 cases reported since its inception. The objective of this seventh annual report is to summarize the Registry's 2016 data and activity with its additional 8529 cases. Cases were identified for inclusion in this report by a query of the ToxIC database for any case entered from 1 January to 31 December 2016. Detailed data was collected from these cases and aggregated to provide information which includes the following: demographics (age, gender, race, ethnicity, HIV status), reason for medical toxicology evaluation (intentional pharmaceutical exposure, envenomation, withdrawal from a substance), agent and agent class, clinical signs and symptoms (vital sign abnormalities, organ system dysfunction), treatments and antidotes administered, fatality and life support withdrawal data. Fifty percent of cases involved females, and adults aged 19-65 were the most commonly reported. There were 86 patients (1.0%) with HIV-positive status known. Non-opioid analgesics were the most commonly reported agent class, with acetaminophen the most common agent reported. There were 126 fatalities reported in 2016 (1.5% of cases). Major trends in demographics and exposure characteristics remained similar overall with past years' reports. While treatment interventions were commonly required, fatalities were rare.
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The case fatality rate for paracetamol poisonings was 0.4% (range 0.1-2.3%).
“The case fatality rate for paracetamol poisonings was 0.4% (range 0.1-2.3%)(Supplementary Figure S8) [58,125-128,135,143,144,148,157,160,196,229,230].”
From Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease (2023) · cites this paper as [143]
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Self-citation
- Authors
- On behalf of the Toxicology Investigators Consortium Study Group, Farrugia, L. A., Rhyee, S. H., Calello, D. P., Campleman, S. L., Riederer, A. M., Malashock, H. R., Pizon, A., Wiegand, T., Wax, P. M., & Brent, J.
- Affiliations
- Hartford Hospital (US)
- Saint Francis Hospital & Medical Center (US)
- Rutgers, The State University of New Jersey (US)
- American College of Medical Toxicology (US)
- University of Arizona (US)
- University of Pittsburgh Medical Center (US)
- Strong Memorial Hospital (US)
- University of Colorado Anschutz (US)
- Corresponding author
- Farrugia, Lynn A.
- ORCID
- Venue
- Journal of Medical Toxicology
- Published
- 2017-08-01
- Volume
- 13
- Issue
- 3
- Pages
- 203-226
- ISSN
- 1556-9039 (ISSN-L)
- 1937-6995
- PMC
- PMC5570732
- OpenAlex
- W2896527510
- Cited by
- 34
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 4 · 2015: 1 · 2014: 3
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Medical Toxicology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- National Institute on Drug Abuse (1R56DA38366, 1R01DA037317-01)
- U.S. Food and Drug Administration
- BTG International Inc.
- Topics
- Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- case registry, poisoning, envenomation, substance withdrawal, paracetamol, non-opioid analgesics, antidotes, treatment outcomes, mortality, demographics, people living with HIV
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Israel, Male, Middle Aged, Poisoning, Prognosis, Referral and Consultation, Registries, Time Factors, Toxicology, United States, Program Evaluation, Databases, Factual, Young Adult, Drug Overdose, Drug-Related Side Effects and Adverse Reactions
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