Comparison of Metformin and N Acetylcysteine on Clinical, Metabolic Parameter and Hormonal Profile in Women with Polycystic Ovarian Syndrome
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Objective Comparison of metformin and N acetylcysteine on clinical, metabolic parameter and hormonal profile in women with polycystic ovarian syndrome. Design Prospective comparative study. Setting Obstetrics and Gynecology department in Kamala Nehru Memorial Hospital Allahabad. Patients On the basis of inclusion and exclusion criteria, 100 patients of PCOS were selected for study and assigned randomly in two groups to receive either metformin (1500 mg/day) (group M) or N acetylcysteine (1800 mg/day) (group N) for 24 weeks. Interventions Metabolic parameter and hormonal profile were determined before and after the treatment. Main outcome measures Metabolic parameters, fasting glucose, fasting insulin and testosterone changes. Results Forty-five patients of both groups were ultimately evaluated. There was a significant improvement of body mass index, waist circumference and waist-hip ratio in group N, but there was no significant difference found in weight reduction among two groups. The biochemical marker of insulin resistance like fasting insulin, fasting glucose/insulin ratio improved significantly in group N. Greater reduction of total testosterone was observed in group N. Conclusions Better improvement of metabolic and hormonal profile was observed in N acetylcysteine group. Because of its less side effect comparing to metformin, NAC can be used as a substitute for insulin-sensitizing agent in treatment of PCOS.
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NAC can enhance lipid profile, hormonal equilibrium, and ovulation status, being a more effective alternative to other insulin-lowering medications.
“A different study also showed that NAC could significantly enhance the lipid profile, hormonal equilibrium, and ovulation status by becoming a more effective alternative to other insulin-lowering medications [191].”
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- Authors
- Chandil, N., Pande, S., Sen, S. S., & Gupta, D.
- Affiliations
- Kamla Nehru Memorial Hospital (IN)
- Dr Baba Saheb Ambedkar Hospital (IN)
- Institute of Medical Sciences (IN)
- Corresponding author
- Chandil, Nidhi
- Venue
- The Journal of Obstetrics and Gynecology of India
- Published
- 2018-05-28
- Volume
- 69
- Issue
- 1
- Pages
- 77-81
- ISSN
- 0971-9202 (ISSN-L)
- 0975-6434
- PMC
- PMC6361173
- OpenAlex
- W2805730015
- Cited by
- 17
- References
- 10
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- The Journal of Obstetrics and Gynecology of India (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, metformin, N-acetylcysteine, insulin resistance, insulin sensitizers, testosterone, fasting insulin, fasting blood glucose, body mass index, waist circumference, hormonal profile, metabolic parameters
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