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Targeted disruption of Rab10 causes early embryonic lethality
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Rab10 plays a critical role in development, as evidenced by the lethality of a Rab10 double knockout in mice.
“Rab10 also plays a critical role in development as evidenced by the lethality of a Rab10 double knock out in mice [45].”
From Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain (2023) · cites this paper as [45]
Rab10 knockout mice are embryonic lethal.
“Due to prior reports showing that Rab10 knockout (KO) mice are embryonic lethal [45], Rab10 KO induced neurons from human iPSCs were used to confirm the specificity of the pRab10 antibody.”
From Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain (2023) · cites this paper as [45]
Germline deletion of RAB10 in mice results in embryonic lethality.
“In further support of the breadth of cellular functions for RAB10, germline deletion of RAB10 in mice results in embryonic lethality (53).”
From The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes (2022) · cites this paper as [53]
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Research works printed but not linked: 15
- Babbey CM, Ahktar N, Wang E, Chen CCH, Grant BD, Dunn KW (2006) Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. Mol Biol Cell 17:3156–3175 · DOI · Paper page
- Chen CC, Schweinsberg PJ, Vashist S, Mareiniss DP, Lambie EJ, Grant BD (2006) RAB-10 is required for endocytic recycling in the Caenorhabditis elegans intestine. Mol Biol Cell 17:1286–1297 · DOI · Paper page
- Chen Y, Wang Y, Zhang J, Deng Y, Jiang L, Song E, Wu XS, Hammer JA, Xu T, Lippincott-Schwartz J (2012) Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. J Cell Biol 198:545–560 · DOI
- Chen S, Li L, Li J, Liu B, Zhu X, Zheng L, Zhang R, Xu T (2014) SEC-10 and RAB-10 coordinate basolateral recycling of clathrin-independent cargo through endosomal tubules in Caenorhabditis elegans. Proc Natl Acad Sci USA 111:15432–15437 · DOI
- Fürthauer M, González-Gaitán M (2009) Endocytic regulation of notch signalling during development. Traffic 10:792–802 · DOI
- Furthauer M, Gonzalez-Gaitan M (2009) Tales of 1001 functions: the multiple roles of membrane trafficking in development. Traffic 10:781–782 · DOI
- Kolotuev I, Apaydin A, Labouesse M (2009) Secretion of Hedgehog-related peptides and WNT during caenorhabditis elegans development. Traffic 10:803–810 · DOI
- Lebreton S, Boissel L, Moreau J (2003) Control of embryonic Xenopus morphogenesis by a Ral-GDS/Xral branch of the Ras signalling pathway. J Cell Sci 116:4651–4662 · DOI
- Lerner DW, McCoy D, Isabella AJ, Mahowald AP, Gerlach GF, Chaudhry TA, Horne-Badovinac S (2013) A Rab10-dependent mechanism for polarized basement membrane secretion during organ morphogenesis. Dev Cell 24:159–168 · DOI
- Lučin P, Mahmutefendić H, Blagojević Zagorac G, Ilić Tomaš M (2014) Cytomegalovirus immune evasion by perturbation of endosomal trafficking. Cell Mol Immunol 12:154–169 · DOI
- Richter S, Voss U, Jurgens G (2009) Post-Golgi traffic in plants. Traffic 10:819–828 · DOI
- Stenmark H (2009) Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Bio 10:513–525 · DOI · Paper page
- Ulrich F, Heisenberg CP (2009) Trafficking and cell migration. Traffic 10:811–818 · DOI
- Xu XH, Deng CY, Liu Y, He M, Peng J, Wang T, Yuan L, Zheng ZS, Blackshear PJ, Luo ZG (2014) MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development. Cell Res 24:576–594 · DOI
- Zerial M, McBride H (2001) Rab proteins as membrane organizers. Nat Rev Mol Cell Bio 2:107–117 · DOI · Paper page
Cited by
Sorted by citations
RAB10: an Alzheimer’s disease resilience locus and potential drug target
Tavana, J., Rosene, M., Jensen, N., Ridge, P. G., Kauwe, J. S. K., & Karch, C. M. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s159148 · Cited by 62
Khan, T. G., Ginsburg, D., & Emmer, B. T. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100248 · Cited by 21
Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain
Singh, V., Menard, M. A., Serrano, G. E., Beach, T. G., Zhao, H. T., Riley-DiPaolo, A., Subrahmanian, N., LaVoie, M. J., & Volpicelli-Daley, L. A. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01704-9 · Cited by 9
Metadata
- Authors
- Lv, P., Sheng, Y., Zhao, Z., Zhao, W., Gu, L., Xu, T., & Song, E.
- Venue
- Protein & Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-04-10
- Volume
- 6
- Issue
- 6
- Pages
- 463-467
- ISSN
- 1674-800X
- 1674-8018
- PMC
- PMC4444807
- Cited by
- 41
- References
- 0
- Language
- en
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