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Rab10 Regulates Membrane Transport through Early Endosomes of Polarized Madin-Darby Canine Kidney Cells

Babbey, Clifford M., Ahktar, Nahid, Wang, Exing, Chen, Carlos Chih-Hsiung, Grant, Barth D., Dunn, Kenneth W.·2006·Molecular Biology of the Cell
DOI 10.1091/mbc.e05-08-0799
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Abstract

Rab10, a protein originally isolated from Madin-Darby Canine Kidney (MDCK) epithelial cells, belongs to a family of Rab proteins that includes Rab8 and Rab13. Although both Rab8 and Rab13 have been found to mediate polarized membrane transport, the function of Rab10 in mammalian cells has not yet been established. We have used quantitative confocal microscopy of polarized MDCK cells expressing GFP chimeras of wild-type and mutant forms of Rab10 to analyze the function of Rab10 in polarized cells. These studies demonstrate that Rab10 is specifically associated with the common endosomes of MDCK cells, accessible to endocytic probes internalized from either the apical or basolateral plasma membrane domains. Expression of mutant Rab10 defective for either GTP hydrolysis or GTP binding increased recycling from early compartments on the basolateral endocytic pathway without affecting recycling from later compartments or the apical recycling pathway. These results suggest that Rab10 mediates transport from basolateral sorting endosomes to common endosomes.

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Metadata

Authors
Babbey, C. M., Ahktar, N., Wang, E., Chen, C. C.-H., Grant, B. D., & Dunn, K. W.
Affiliations
  • *Department of Medicine, Division of Nephrology, Indiana University Medical Center, Indianapolis, IN 46202; and
  • Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854
Venue
Molecular Biology of the Cell
Publisher
American Society for Cell Biology (ASCB)
Published
2006-07
Volume
17
Issue
7
Pages
3156-3175
ISSN
  • 1059-1524
  • 1939-4586
DOI
10.1091/mbc.e05-08-0799
Cited by
164
References
0
Language
en

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