The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization
Open accessAbstract
Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations are mainly sensory and vascular disorders such as pruritus and erythema. Transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively) are non-selective cation channels known to specifically participate in pain and CNI. Both TRPV1 and TRPA1 are co-expressed in a large subset of sensory nerves, where they integrate numerous noxious stimuli. It is now clear that the expression of both channels also extends far beyond the sensory nerves in the skin, occuring also in keratinocytes, mast cells, dendritic cells, and endothelial cells. In these non-neuronal cells, TRPV1 and TRPA1 also act as nociceptive sensors and potentiate the inflammatory process. This review discusses the role of TRPV1 and TRPA1 in the modulation of inflammatory genes that leads to or maintains CNI in sensory neurons and non-neuronal skin cells. In addition, this review provides a summary of current research on the intracellular sensitization pathways of both TRP channels by other endogenous inflammatory mediators that promote the self-maintenance of CNI.
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Cites
The capsaicin receptor: a heat-activated ion channel in the pain pathway
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The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
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ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
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Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
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TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
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Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
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Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
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Structure of the TRPV1 ion channel determined by electron cryo-microscopy
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TRPA1 mediates formalin-induced pain
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Cited by
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
Choi, J. E., & Di Nardo, A. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0675-z · Cited by 331
Metadata
- Authors
- Gouin, O., L’Herondelle, K., Lebonvallet, N., Le Gall-Ianotto, C., Sakka, M., Buhé, V., Plée-Gautier, E., Carré, J.-L., Lefeuvre, L., Misery, L., & Le Garrec, R.
- Venue
- Protein & Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-03-31
- Volume
- 8
- Issue
- 9
- Pages
- 644-661
- ISSN
- 1674-800X (ISSN-L)
- 1674-8018
- OpenAlex
- W2599204814
- Cited by
- 425
- References
- 155
- FWCI
- 16.18
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gouin, O., L’Herondelle, K., Lebonvallet, N., Le Gall-Ianotto, C., Sakka, M., Buhé, V., Plée-Gautier, E., Carré, J.-L., Lefeuvre, L., Misery, L., & Le Garrec, R. (2017). TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization. Protein & Cell. https://doi.org/10.1007/s13238-017-0395-5
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