The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
Skin neurogenic inflammation
Open accessAbstract
The epidermis closely interacts with nerve endings, and both epidermis and nerves produce substances for mutual sustenance. Neuropeptides, like substance P (SP) and calcitonin gene-related protein (CGRP), are produced by sensory nerves in the dermis; they induce mast cells to release vasoactive amines that facilitate infiltration of neutrophils and T cells. Some receptors are more important than others in the generation of itch. The Mas-related G protein-coupled receptors (Mrgpr) family as well as transient receptor potential ankyrin 1 (TRPA1) and protease activated receptor 2(Par2) have important roles in itch and inflammation. The activation of MrgprX1 degranulates mast cells to communicate with sensory nerve and cutaneous cells for developing neurogenic inflammation. Mrgprs and transient receptor potential vanilloid 4 (TRPV4) are crucial for the generation of skin diseases like rosacea, while SP, CGRP, somatostatin, β-endorphin, vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase-activating polypeptide (PACAP) can modulate the immune system during psoriasis development. The increased level of SP, in atopic dermatitis, induces the release of interferon (IFN)-γ, interleukin (IL)-4, tumor necrosis factor (TNF)-α, and IL-10 from the peripheral blood mononuclear leukocytes. We are finally starting to understand the intricate connections between the skin neurons and resident skin cells and how their interaction can be key to controlling inflammation and from there the pathogenesis of diseases like atopic dermatitis, psoriasis, and rosacea.
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Cites
Williams, H. C., Leung, D. Y. M., Thestrup‐Pedersen, K., & David, T. J. (2000) · Cited by 4,596
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T. R., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,486
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
McLatchie, L. M., Fraser, N. J., Main, M. J., Wise, A., Brown, J., Thompson, N., Solari, R., Lee, M. G., & Foord, S. M. (1998) · Nature · doi:10.1038/30666 · Cited by 2,134
A systematic review of worldwide epidemiology of psoriasis
Michalek, I. M., Loring, B., & John, S. M. (2017) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13854 · Cited by 1,150
Leung, D. Y., & Bieber, T. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12193-9 · Cited by 1,147
The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis
Di Cesare, A., Di Meglio, P., & Nestle, F. O. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.59 · Cited by 1,129
The movements and innervation of the small intestine
Bayliss, W. M., & Starling, E. H. (1899) · The Journal of Physiology · doi:10.1113/jphysiol.1899.sp000752 · Cited by 990
The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch
Wilson, S. R., Thé, L., Batia, L. M., Beattie, K., Katibah, G. E., McClain, S. P., Pellegrino, M., Estandian, D. M., & Bautista, D. M. (2013) · Cell · doi:10.1016/j.cell.2013.08.057 · Cited by 987
Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus
Liu, Q., Tang, Z., Surdenikova, L., Kim, S., Patel, K. N., Kim, A., Ru, F., Guan, Y., Weng, H.-J., Geng, Y., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.034 · Cited by 813
Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology
Chiu, I. M., von Hehn, C. A., & Woolf, C. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3144 · Cited by 686
Cited by
Fournière, M., Latire, T., Souak, D., Feuilloley, M. G. J., & Bedoux, G. (2020) · Microorganisms · doi:10.3390/microorganisms8111752 · Cited by 227
Organization of the skin immune system and compartmentalized immune responses in infectious diseases
Quaresma, J. A. S. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00034-18 · Cited by 149
Itch in Atopic Dermatitis – What Is New?
Legat, F. J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.644760 · Cited by 82
Research progress in calcitonin gene-related peptide and bone repair
Wang, Q., Qin, H., Deng, J., Xu, H., Liu, S., Weng, J., & Zeng, H. (2023) · Biomolecules · doi:10.3390/biom13050838 · Cited by 58
Deng, Z., Chen, M., Zhao, Z., Xiao, W., Liu, T., Peng, Q., Wu, Z., Xu, S., Shi, W., Jian, D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39761-2 · Cited by 50
Metadata
- Authors
- Choi, J. E., & Di Nardo, A.
- Venue
- Seminars in Immunopathology
- Published
- 2018-04-30
- Volume
- 40
- Issue
- 3
- Pages
- 249-259
- ISSN
- 1863-2297 (ISSN-L)
- 1863-2300
- OpenAlex
- W2802723594
- Cited by
- 331
- References
- 128
- FWCI
- 21.48
- Type
- journal article
- Language
- en
- Open access
- green
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