Oral microbiomes: more and more importance in oral cavity and whole body
Open accessAbstract
Microbes appear in every corner of human life, and microbes affect every aspect of human life. The human oral cavity contains a number of different habitats. Synergy and interaction of variable oral microorganisms help human body against invasion of undesirable stimulation outside. However, imbalance of microbial flora contributes to oral diseases and systemic diseases. Oral microbiomes play an important role in the human microbial community and human health. The use of recently developed molecular methods has greatly expanded our knowledge of the composition and function of the oral microbiome in health and disease. Studies in oral microbiomes and their interactions with microbiomes in variable body sites and variable health condition are critical in our cognition of our body and how to make effect on human health improvement.
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Fixed appliance treatment is associated with increased bacterial accumulation, which may alter the oral ecosystem towards pathogenic colonization, and increases the risk of caries, periodontal inflammation, and enamel demineralization.
“Fixed appliance treatment is associated with increased bacterial accumulation, which may alter the oral ecosystem towards pathogenic colonization [7, 8], and increases the risk of caries, periodontal inflammation, and enamel demineralization [6, 9].”
From Influence of elastomeric and steel ligatures on periodontal health during fixed appliance orthodontic treatment: a systematic review and meta-analysis (2024) · cites this paper as [7]
The Introduction (page unavailable) says that an imbalance of oral microbes contributes to caries and periodontitis, supporting the general link between a changed oral ecosystem and disease. The Caries and Periodontal diseases sections also discuss disease-associated bacteria. However, the paper does not link fixed appliances to increased bacterial accumulation or pathogenic colonization; the sentence cites other sources for the specific disease-risk outcomes. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThe nonshedding enamel surfaces, the gingival crevice, the mucosal epithelium of the cheeks, the tongue dorsum, and tonsillar crypts together present the oral cavity as a complex microbial environment with wide-ranging topography.
“The nonshedding enamel surfaces, the gingival crevice, the mucosal epithelium of the cheeks, the tongue dorsum, and tonsillar crypts, together present the oral cavity as a complex microbial environment with wide‐ranging topography.227, 228”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [228]
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References 128 · Cited by 770
Research works printed but not linked: 1
- Hu X Zhang Q Hua H Chen F Changes in the salivary microbiota of oral leukoplakia and oral cancer Oral Oncol 2016 56 6 8 27026576
- Authors
- Gao, L., Xu, T., Huang, G., Jiang, S., Gu, Y., & Chen, F.
- Affiliations
- Peking University School and Hospital of Stomatology (CN)
- Corresponding author
- Chen, Feng
- Venue
- Protein & Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-05
- Volume
- 9
- Issue
- 5
- Pages
- 488-500
- ISSN
- 1674-800X (ISSN-L)
- 1674-8018
- PMC
- PMC5960472
- OpenAlex
- W2801072950
- Cited by
- 770
- References
- 128
- Citations by year
- 2026: 61 · 2025: 96 · 2024: 115 · 2023: 129 · 2022: 106 · 2021: 118 · 2020: 96 · 2019: 41 · 2018: 8
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Protein & Cell (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81771027)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
- Keywords
- oral microbiota, oral cavity, microbial communities, oral diseases, systemic disease, dysbiosis, host-microbe interactions, oral health, molecular microbiology
- MeSH terms
- Humans, Mouth, Mouth Diseases, Human Body, Microbiota
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