The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
Focused Ultrasound for Neuromodulation
Open accessAbstract
For more than 70 years, the promise of noninvasive neuromodulation using focused ultrasound has been growing while diagnostic ultrasound established itself as a foundation of clinical imaging. Significant technical challenges have been overcome to allow transcranial focused ultrasound to deliver spatially restricted energy into the nervous system at a wide range of intensities. High-intensity focused ultrasound produces reliable permanent lesions within the brain, and low-intensity focused ultrasound has been reported to both excite and inhibit neural activity reversibly. Despite intense interest in this promising new platform for noninvasive, highly focused neuromodulation, the underlying mechanism remains elusive, though recent studies provide further insight. Despite the barriers, the potential of focused ultrasound to deliver a range of permanent and reversible neuromodulation with seamless translation from bench to the bedside warrants unparalleled attention and scientific investment. Focused ultrasound boasts a number of key features such as multimodal compatibility, submillimeter steerable focusing, multifocal, high temporal resolution, coregistration, and the ability to monitor delivered therapy and temperatures in real time. Despite the technical complexity, the future of noninvasive focused ultrasound for neuromodulation as a neuroscience and clinical platform remains bright.
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“HIFU creates permanent lesions through coagulation of cellular proteins and thermal ablation [58]”
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Cites
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Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression
Guo, B., Zhang, M., Hao, W., Wang, Y., Zhang, T., & Liu, C. (2023) · Translational Psychiatry · doi:10.1038/s41398-022-02297-y · Cited by 404
Non-invasive transcranial ultrasound stimulation for neuromodulation
Darmani, G., Bergmann, T. O., Pauly, K. B., Caskey, C. F., de Lecea, L., Fomenko, A., Fouragnan, E. F., Legon, W., Murphy, K. R., Nandi, T., et al. (2021) · Clinical Neurophysiology · doi:10.1016/j.clinph.2021.12.010 · Cited by 335
Beisteiner, R., Matt, E., Fan, C., Baldysiak, H., Schönfeld, M., Philippi Novak, T., Amini, A., Aslan, T., Reinecke, R., Lehrner, J., et al. (2020) · Advanced Science · doi:10.1002/advs.201902583 · Cited by 269
di Biase, L., Falato, E., & Di Lazzaro, V. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00549 · Cited by 166
Reversible neuroinhibition by focused ultrasound is mediated by a thermal mechanism
Darrow, D., O'Brien, P. D., Richner, T. J., Netoff, T. I., & Ebbini, E. S. (2019) · Brain stimulation · doi:10.1016/j.brs.2019.07.015 · Cited by 136
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Metadata
- Authors
- Darrow, D. P.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Darrow, David P
- ORCID
- Darrow, David P
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 16
- Issue
- 1
- Pages
- 88-99
- ISSN
- 1878-7479 (ISSN-L)
- PMC
- PMC6361056
- OpenAlex
- W2902574161
- Cited by
- 190
- References
- 125
- Citations by year
- 2026: 29 · 2025: 28 · 2024: 24 · 2023: 36 · 2022: 33 · 2021: 18 · 2020: 12 · 2019: 9
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurotherapeutics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
- Keywords
- focused ultrasound, neuromodulation, transcranial ultrasound, non-invasive brain stimulation, high-intensity focused ultrasound, low-intensity focused ultrasound, multimodal imaging, real-time temperature monitoring, mechanism of action
- MeSH terms
- Animals, Brain, Humans, Ultrasonic Therapy
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