A comprehensive review of SHP2 and its role in cancer

Cites (319)

Items 201–320 of 320

1. Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells
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2. Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET
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3. SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer
   Hao Chen, Sarah Libring, Kasi Viswanatharaju Ruddraraju, Jinmin Miao, Luis Solorio, Zhong‐Yin Zhang, Michael K. Wendt · 2020 · Oncogene
4. A novel double-negative feedback loop between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor growth
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5. Blocking interaction between SHP2 and PD‐1 denotes a novel opportunity for developing PD‐1 inhibitors
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6. Inhibition of IFN-γ-Induced STAT1 Tyrosine Phosphorylation by Human CMV Is Mediated by SHP2
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7. Tanshinone IIA induced cell death via miR30b-p53-PTPN11/SHP2 signaling pathway in human hepatocellular carcinoma cells
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8. A suggested role for mitochondria in Noonan syndrome
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9. Regulation of RhoA-dependent ROCKII activation by Shp2
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10. Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells
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11. Selective Sequestration of STAT1 in the Cytoplasm via Phosphorylated SHP-2 Ameliorates Murine Experimental Colitis
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12. SHP2 phosphatase as a novel therapeutic target for melanoma treatment
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13. Off‐target inhibition by active site‐targeting <scp>SHP</scp> 2 inhibitors
    Tsutsumi, Ryouhei, Ran, Hao, Neel, Benjamin G. · 2018 · FEBS Open Bio
14. Targeted Disruption of Shp2 in Chondrocytes Leads to Metachondromatosis With Multiple Cartilaginous Protrusions
    Harry K.W. Kim, Gen‐Sheng Feng, Di Chen, Philip D. King, Nobuhiro Kamiya · 2013 · Journal of Bone and Mineral Research
15. SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer
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16. The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling
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17. Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation
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18. p190-RhoGAP as an integral component of the Tiam1/Rac1-induced downregulation of Rho
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19. Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development
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20. Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2
    Jonathan R. LaRochelle, Michelle Fodor, Jana M. Ellegast, Xiaoxi Liu, Vidyasiri Vemulapalli, Morvarid Mohseni, Travis Stams, Sara J. Buhrlage, Kimberly Stegmaier, Matthew J. LaMarche et al. · 2017 · Bioorganic & Medicinal Chemistry
21. Transcriptional Co-activator Functions of YAP and TAZ Are Inversely Regulated by Tyrosine Phosphorylation Status of Parafibromin
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22. Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein–Protein Interactions
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23. Role of protein tyrosine phosphatase SHP2 in barrier function of pulmonary endothelium
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24. Hepatocyte growth factor (HGF) signals through SHP2 to regulate primary mouse myoblast proliferation
    Ju Li, Sarah A Reed, Sally Johnson · 2009 · Experimental Cell Research
25. Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies
    Xia Liu, Hong Zheng, Xiaobo Li, Siying Wang, Howard J. Meyerson, Wentian Yang, Benjamin G. Neel, Cheng‐Kui Qu · 2016 · Proceedings of the National Academy of Sciences
26. Modulation of Fatty Acid Synthase Degradation by Concerted Action of p38 MAP Kinase, E3 Ligase COP1, and SH2-Tyrosine Phosphatase Shp2
    Jianxiu Yu, Rong Deng, Helen He Zhu, Sharon S. Zhang, Changhong Zhu, Marc Montminy, Roger J. Davis, Gen‐Sheng Feng · 2012 · Journal of Biological Chemistry
27. Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase
    Koichi Miura, Yuki Wakayama, Mishie Ann Tanino, Yasuko Orba, Hirofumi Sawa, Masanori Hatakeyama, Shinya Tanaka, Hisataka Sabe, Naoki Mochizuki · 2013 · Oncogene
28. Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2
    Jie Sun, Shaoying Lu, Mingxing Ouyang, Li-Jung Lin, Yue Zhuo, Bo Liu, Shu Chien, Benjamin G. Neel, Yingxiao Wang · 2013 · Nature Communications
29. Induction of a Tumor-associated Activating Mutation in Protein Tyrosine Phosphatase Ptpn11 (Shp2) Enhances Mitochondrial Metabolism, Leading to Oxidative Stress and Senescence
    Hong Zheng, Shanhu Li, Peter Hsu, Cheng‐Kui Qu · 2013 · Journal of Biological Chemistry
30. Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2
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31. Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma
    Valentina E. Schneeberger, Yuan Ren, Noreen Luetteke, Qingling Huang, Liwei Chen, Harshani R. Lawrence, Nicholas J. Lawrence, Eric B. Haura, John M. Koomen, Domenico Coppola et al. · 2015 · Oncotarget
32. Constitutively Active SHP2 Cooperates with HoxA10 Overexpression to Induce Acute Myeloid Leukemia
    Hao Wang, Stephan C. Lindsey, Iwona M. Konieczna, Ling Bei, Elizabeth Horvath, Weiqi Huang, Gurveen Sethi Saberwal, Elizabeth A. Eklund · 2008 · Journal of Biological Chemistry
33. PD-1 Ligand Expression in Epithelial Thyroid Cancers: Potential Clinical Implications
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34. A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2
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35. Src and SHP2 coordinately regulate the dynamics and organization of vimentin filaments during cell migration
    Cheng-Yi Yang, Po-Wei Chang, Wen‐Hsin Hsu, Hsuan-Chia Chang, Chien‐Lin Chen, Chien‐Chen Lai, Wen‐Tai Chiu, Hong‐Chen Chen · 2019 · Oncogene
36. SHP2 Mediates the Localized Activation of Fyn Downstream of the α6β4 Integrin To Promote Carcinoma Invasion
    Xiaoqing Yang, Udayan Dutta, Leslie M. Shaw · 2010 · Molecular and Cellular Biology
37. SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity
    Chunlin Zuo, Lijun Wang, Raghavendra M. Kamalesh, Margot E. Bowen, Douglas C. Moore, Mark S. Dooner, Anthony M. Reginato, Qian Wu, Christoph Schorl, Yueming Song et al. · 2018 · Bone Research
38. Regulation of peripheral and central immunity: Understanding the role of Src homology 2 domain-containing tyrosine phosphatases, SHP-1 & SHP-2
    Manika Garg, Mohd Wahid, Farah Khan · 2019 · Immunobiology
39. Targeted Degradation of the Oncogenic Phosphatase SHP2
    Vemulapalli, Vidyasiri, Donovan, Katherine A., Seegar, Tom C. M., Rogers, Julia M., Bae, Munhyung, Lumpkin, Ryan J., Cao, Ruili, Henke, Matthew T., Ray, Soumya S., Fischer, Eric S. et al. · 2021 · Biochemistry
40. Abnormal repression of SHP-1, SHP-2 and SOCS-1 transcription sustains the activation of the JAK/STAT3 pathway and the progression of the disease in multiple myeloma
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41. Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase
    Hao Ran, Shuangbo Kong, Shuang Zhang, Jianghong Cheng, Chan Zhou, Bo He, Qiliang Xin, John P. Lydon, Francesco John DeMayo, Gen‐Sheng Feng et al. · 2017 · Proceedings of the National Academy of Sciences
42. Regulation of SHP2 by PTEN/AKT/GSK-3β signaling facilitates IFN-γ resistance in hyperproliferating gastric cancer
    Po‐Chun Tseng, Wei‐Ching Huang, Chia‐Ling Chen, Bor‐Shyang Sheu, Yan‐Shen Shan, Cheng‐Chieh Tsai, Chi‐Yun Wang, Su-O Chen, Chia-Yuan Hsieh, Chiou‐Feng Lin · 2012 · Immunobiology
43. Expression and Clinical Significance of SHP2 in Gastric Cancer
    Shengzhang Dong, Li Fq, Q Zhang, K-Z Lv, H-L Yang, Yuzhen Gao, J-R Yu · 2012 · Journal of International Medical Research
44. Phosphatase-independent functions of SHP2 and its regulation by small molecule compounds
    Wenjie Guo, Qiang Xu · 2020 · Journal of Pharmacological Sciences
45. Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer
    Peifen Cai, Wenjie Guo, Huaqin Yuan, Qian Li, Weicheng Wang, Yang Sun, Xiaomin Li, Yanhong Gu · 2013 · Biomedicine & Pharmacotherapy
46. SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes
    Lijun Wang, Jiahui Huang, Douglas C. Moore, Chunlin Zuo, Qian Wu, Liqin Xie, Klaus von der Mark, Xin Yuan, Di Chen, Matthew L. Warman et al. · 2017 · Scientific Reports
47. Activating Mutations in Protein Tyrosine Phosphatase Ptpn11 (Shp2) Enhance Reactive Oxygen Species Production That Contributes to Myeloproliferative Disorder
    Dan Xu, Hong Zheng, Wen-Mei Yu, Cheng‐Kui Qu · 2013 · PLoS ONE
48. SHP2 overexpression enhances the invasion and metastasis of ovarian cancer in vitro and in vivo
    Zhongqian Hu, Jia Li, Qi Gao, Shuping Wei, Bin Yang · 2017 · OncoTargets and Therapy
49. Shipping out MEK inhibitor resistance with SHP2 inhibitors
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50. Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling
    Vidyasiri Vemulapalli, Lily A. Chylek, Alison R. Erickson, Anamarija Pfeiffer, Khal-Hentz Gabriel, Jonathan R. LaRochelle, Kartik Subramanian, Ruili Cao, Kimberly Stegmaier, Morvarid Mohseni et al. · 2021 · eLife
51. Phosphotyrosine couples peptide binding and SHP2 activation via a dynamic allosteric network
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52. Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3
    Chen Qi, T. Han, Hua Tang, Ke-Nan Huang, Jie Min, Jing Li, Xin-Yu Ding, Zhi-fei Xu · 2017 · International Journal of Molecular Sciences
53. SHP2 associates with nuclear localization of STAT3: significance in progression and prognosis of colorectal cancer
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54. Quantitative phosphoproteomic analysis reveals involvement of PD-1 in multiple T cell functions
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55. Interleukin-6 promotes a STAT3-PRL3 feedforward loop via SHP2 repression in Multiple Myeloma.
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56. Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development
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57. The pro-metastasis tyrosine phosphatase, PRL-3 (PTP4A3), is a novel mediator of oncogenic function of BCR-ABL in human chronic myeloid leukemia
    Jianbiao Zhou, Lip-Lee Cheong, Shaw-Cheng Liu, Phyllis S.Y. Chong, Sylvia Mahara, Chonglei Bi, Kelly OK Ong, Qi Zeng, Wee Joo Chng · 2012 · Molecular Cancer
58. Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression
    Yao-Chen Wang, De‐Wei Wu, Tzu‐Chin Wu, Lee Wang, Chih‐Yi Chen, Huei Lee · 2018 · International Journal of Biological Sciences
59. Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration
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60. The YAP-Interacting Phosphatase SHP2 Can Regulate Transcriptional Coactivity and Modulate Sensitivity to Chemotherapy in Cholangiocarcinoma
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61. MicroRNA-186 serves as a tumor suppressor in oral squamous cell carcinoma by negatively regulating the protein tyrosine phosphatase SHP2 expression
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62. Protein tyrosine phosphatase 11 acts through RhoA/ROCK to regulate eosinophil accumulation in the allergic airway
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63. Grb2 binding induces phosphorylation-independent activation of Shp2
    Chi‐Chuan Lin, Łukasz Wieteska, Kin Man Suen, Arnout P. Kalverda, Zamal Ahmed, John Edward Ladbury · 2021 · Communications Biology
64. The tyrosine phosphatase SHP2 promotes proliferation and oxaliplatin resistance of colon cancer cells through AKT and ERK
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65. Overexpression of Protein Phosphatase Non-receptor Type 11 (PTPN11) in Gastric Carcinomas
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66. Protein-tyrosine phosphatase SH-PTP2 (PTPN11) is localized to 12q24.1?24.3
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67. SHP2 deficiency promotes Staphylococcus aureus pneumonia following influenza infection
    Wei Ouyang, Chao Liu, Ying Pan, Han Yu, Liping Yang, Jingyan Xia, Feng Xu · 2019 · Cell Proliferation
68. The loops of the N-SH2 binding cleft do not serve as allosteric switch in SHP2 activation
    Massimiliano Anselmi, Jochen S. Hub · 2021 · Proceedings of the National Academy of Sciences
69. Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity
    Brian T. Burmeister, Li Wang, Matthew G. Gold, Randal A. Skidgel, John P. O’Bryan, Graeme K. Carnegie · 2015 · Journal of Biological Chemistry
70. Isovitexin Inhibits Ginkgolic Acids-Induced Inflammation Through Downregulating SHP2 Activation
    Yiwei Zhang, Zhipeng Qi, Wenjie Wang, Lei Wang, Fuliang Cao, Linguo Zhao, Xianying Fang · 2021 · Frontiers in Pharmacology
71. Tyrosine Phosphatase Shp2 Mediates the Estrogen Biological Action in Breast Cancer via Interaction with the Estrogen Extranuclear Receptor
    Jun Li, Yujia Kang, Longgang Wei, Wenjie Liu, Yingpu Tian, Baozhen Chen, Xiandong Lin, Yang Li, Gen‐Sheng Feng, Zhongxian Lu · 2014 · PLoS ONE
72. SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells
    Young Cha, Kyung‐Soon Park · 2010 · FEBS Letters
73. The gain‐of‐function mutation E76K in SHP2 promotes CAC tumorigenesis and induces EMT via the Wnt/β‐catenin signaling pathway
    Qian Zhang, Yao Li, Rongrong Zhao, Xinyi Wang, Chuling Fan, Youzhi Xu, Yakun Liu, Jiabin Li, Siying Wang · 2018 · Molecular Carcinogenesis
74. Decline in arylsulfatase B expression increases EGFR expression by inhibiting the protein-tyrosine phosphatase SHP2 and activating JNK in prostate cells
    Sumit Bhattacharyya, Leo Feferman, Xiaorui Han, Yilan Ouyang, Fuming Zhang, Robert J. Linhardt, Joanne Kramer Tobacman · 2018 · Journal of Biological Chemistry
75. Association of nuclear localization of SHP2 and YAP1 with unfavorable prognosis in non-small cell lung cancer
    Ming‐Jenn Chen, Yaochen Wang, De‐Wei Wu, Chi-Yi Chen, Huei Lee · 2019 · Pathology - Research and Practice
76. Growth Factors, and Cytokines; Understanding the Role of Tyrosine Phosphatase SHP2 in Gametogenesis and Early Embryo Development
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77. Recruitment of the Tyrosine Phosphatase Src Homology 2 Domain Tyrosine Phosphatase-2 to the p85 Subunit of Phosphatidylinositol-3 (PI-3) Kinase Is Required for Insulin-Like Growth Factor-I-Dependent PI-3 Kinase Activation in Smooth Muscle Cells
    Mijin Kwon, Ling Yan, Laura A. Maile, Jane Badley-Clarke, David R. Clemmons · 2005 · Endocrinology
78. Expression and prognosis value of SHP2 in patients with pancreatic ductal adenocarcinoma
    Jiawei Zheng, Shanshan Huang, Yu-Fang Huang, Song Li, Yin Yin, Wencui Kong, Xiong Chen, Xuenong Ouyang · 2015 · Tumor Biology
79. Structural Determinants of Phosphopeptide Binding to the N‑Terminal Src Homology 2 Domain of the SHP2 Phosphatase
    Massimiliano Anselmi, Paolo A. Calligari, Jochen S. Hub, Marco Tartaglia, Gianfranco Bocchinfuso, Lorenzo Stella · 2020 · Journal of Chemical Information and Modeling
80. Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth
    Yuyi Wang, Ombretta Salvucci, Hidetaka Ohnuki, Andy D. Tran, Taekyu Ha, Jingxin Feng, Michael DiPrima, Hyeongil Kwak, Dunrui Wang, Yanlin Yu et al. · 2021 · EMBO Molecular Medicine
81. Leukocyte immunoglobulin-like receptor B4 protects against cardiac hypertrophy via SHP-2-dependent inhibition of the NF-κB pathway
    Heng Zhou, Ning Li, Yuan Yuan, Ya‐Ge Jin, Qingqing Wu, Ling Yan, Zhou‐Yan Bian, Wei Deng, Zhi‐Gang She, Hongliang Li et al. · 2020 · Journal of Molecular Medicine
82. SHP2 Targets ITK Downstream of PD-1 to Inhibit T Cell Function
    Marianne Strazza, Kieran R. Adam, Shalom Lerrer, Johanna Straube, Sabina Sandigursky, Beatrix M. Ueberheide, Adam Mor · 2021 · Inflammation
83. Activating Mutation of SHP2 Establishes a Tumorigenic Phonotype Through Cell-Autonomous and Non-Cell-Autonomous Mechanisms
    Lei Dong, Da Woon Han, Xinyi Meng, Mengchuan Xu, Chuwen Zheng, Xia Qin · 2021 · Frontiers in Cell and Developmental Biology
84. Intersectin 1 Enhances Cbl Ubiquitylation of Epidermal Growth Factor Receptor through Regulation of Sprouty2-Cbl Interaction
    Mustafa Nazir Okur, Jolene Ooi, Chee Wai Fong, Natalia J. Martinez, Carlota A. García-Domínguez, José M. Rojas, Graeme R. Guy, John P. O’Bryan · 2011 · Molecular and Cellular Biology
85. Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2
    Zhang, Ruo-Yu, Yu, Zhi-Hong, Chen, Lan, Walls, Chad D., Zhang, Sheng, Wu, Li, Zhang, Zhong-Yin · 2020 · Journal of Biological Chemistry
86. Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling
    Saori Noda, Atsushi Takahashi, Takeru Hayashi, Sei-ichi Tanuma, Masanori Hatakeyama · 2015 · Biochemical and Biophysical Research Communications
87. Increased expression of tyrosine phosphatase SHP-2 inHelicobacter pylori-infected gastric cancer
    Jing Jiang · 2013 · World Journal of Gastroenterology
88. Deregulation of hsa_circ_0001971/miR-186 and hsa_circ_0001874/miR-296 signaling pathways promotes the proliferation of oral squamous carcinoma cells by synergistically activating SHP2/PLK1 signals
    Wang Jun, Ouyang Shaobo, Zhang Xianhua, Siyu Zhao, Cheng Mingyang, Xin Fan, Cai Ying, Lan Liao · 2021 · Scientific Reports
89. Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD–Driven AML
    Anamarija Pfeiffer, Giulia Franciosa, Marie Locard‐Paulet, Ilaria Piga, Kristian Reckzeh, Vidyasiri Vemulapalli, Stephen C. Blacklow, Kim Theilgaard‐Mönch, Lars Juhl Jensen, Jesper Velgaard Olsen · 2022 · Cancer Research
90. Receptor Tyrosine Kinase Ubiquitylation Involves the Dynamic Regulation of Cbl-Spry2 by Intersectin 1 and the Shp2 Tyrosine Phosphatase
    Mustafa Nazir Okur, Angela Russo, John P. O’Bryan · 2013 · Molecular and Cellular Biology
91. The prognostic significance of SHP2 and its binding protein Hook1 in non-small cell lung cancer
    Lingjuan He, Yinyan Li, Xin Huang, Hongqiang Cheng, Yuehai Ke, Lin-run Wang · 2019 · OncoTargets and Therapy
92. SHP2 inhibition enhances the anticancer effect of Osimertinib in EGFR T790M mutant lung adenocarcinoma by blocking CXCL8 loop mediated stemness
    Leiming Xia, Fan Yang, Xiao Qin Wu, Suzhi Li, Chen Kan, Hong Zheng, Siying Wang · 2021 · Cancer Cell International
93. Emerging chemical scaffolds with potential SHP2 phosphatase inhibitory capabilities – A comprehensive review
    Rati Kailash Prasad Tripathi, Senthil Raja Ayyannan · 2020 · Chemical Biology & Drug Design
94. The Novel Role of the C-terminal Region of SHP-2
    Qunhua Huang, Nicole Lerner‐Marmarosh, Wenyi Che, Shinsuke Ohta, Masaki Osawa, Masanori Yoshizumi, Michael Glassman, Yan Chen, Bradford C. Berk, Jun‐ichi Abe · 2002 · Journal of Biological Chemistry
95. SHP-2 restricts apoptosis induced by chemotherapeutic agents via Parkin-dependent autophagy in cervical cancer
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96. SHP2 Inhibition Enhances the Effects of Tyrosine Kinase Inhibitors in Preclinical Models of Treatment-naïve ALK-, ROS1- , or EGFR -altered Non–small Cell Lung Cancer
    Hirohisa Kano, Eiki Ichihara, Hiromi Watanabe, Kazuya Nishii, Chihiro Ando, Takamasa Nakasuka, Kiichiro Ninomiya, Yuka Kato, Toshio Kubo, Kammei Rai et al. · 2021 · Molecular Cancer Therapeutics
97. Shp2 confers cisplatin resistance in small cell lung cancer via an AKT-mediated increase in CA916798
    Xuemei Yang, Chunlan Tang, Hu Luo, Haijing Wang, Xiangdong Zhou · 2017 · Oncotarget
98. Reciprocal regulation of TLR2-mediated IFN-β production by SHP2 and Gsk3β
    Jin Hee Park, Ryeojin Ko, Soo Young Lee · 2017 · Scientific Reports
99. Gain-Of-Function E76K-Mutant SHP2 Promotes Cell Proliferation, Metastasis, And Tumor Growth In Glioblastoma Through Activation Of The ERK/CREB Pathway
    Fan Yang, Mo Xu, Shiqing Wang, Le Song, Dandan Yu, Yao Li, Rui Cao, Xiong Zhang, Zhijun Chen, Qian Zhang et al. · 2019 · OncoTargets and Therapy
100. SHP2 as a Potential Therapeutic Target in Diffuse-Type Gastric Carcinoma Addicted to Receptor Tyrosine Kinase Signaling
     Yuko Nagamura, Makoto Miyazaki, Yoshiko Nagano, Arata Tomiyama, Rieko Ohki, Kazuyoshi Yanagihara, Ryuichi Sakai, Hideki Yamaguchi · 2021 · Cancers
101. The Phosphatase SHP-2 Activates HIF-1α in Wounds In Vivo by Inhibition of 26S Proteasome Activity
     Yvonn Heun, Katharina Grundler Groterhorst, Kristin Pogoda, Bjoern F. Kraemer, Alexander Pfeifer, Ulrich Pohl, Hanna Mannell · 2019 · International Journal of Molecular Sciences
102. Tumorigenic role of YAP in hepatocellular carcinogenesis is involved in SHP2 whose function is different in vitro and in vivo
     Min-Kyung Kim, Jee Young Park, Yu Na Kang · 2018 · Pathology - Research and Practice
103. Novel Small-Molecule Inhibitor for the Oncogenic Tyrosine Phosphatase SHP2 with Anti-Breast Cancer Cell Effects
     Zachary Hartman, Werner J. Geldenhuys, Yehenew M. Agazie · 2020 · ACS Omega
104. SHP2 Potentiates the Oncogenic Activity of β-Catenin to Promote Triple-Negative Breast Cancer
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105. The Tyrosine Phosphatase SHP2 Associates with CUB Domain-Containing Protein-1 (CDCP1), Regulating Its Expression at the Cell Surface in a Phosphorylation-Dependent Manner
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109. What Have We Learned from SH2 Domains?
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