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General Considerations of Dose-Effect and Dose-Response Relationships**This chapter is based on the chapter with the same title by Emil A. Pfitzer and Velimir Vouk in the 2nd edition of the Handbook.Disclaimer: The findings and conclusions in this chapter are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention/Agency for Toxic Substances and Disease Registry or the Environmental Protection Agency.

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