Polynucleotide and Hyaluronic Acid Mixture for Skin Wound Dressing for Accelerated Wound Healing
Open accessAbstract
Background Skin wound healing is a complex process requiring coordinated cellular and molecular interactions. Polynucleotides (PN) and hyaluronic acid (HA) have emerged as promising agents in regenerative medicine due to their ability to enhance cellular proliferation, angiogenesis, and extracellular matrix (ECM) remodeling. Combining PN and HA offers potential synergistic effects, accelerating wound repair. Methods PN and HA hydrogels were prepared and evaluated for viscosity and gel stability. Their effects on human dermal fibroblasts (HDF) and keratinocytes (HaCaT) were assessed using migration, proliferation assays, and gene expression analyses for vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and matrix metalloproteinase-10 (MMP-10). In vivo studies were conducted using a mouse wound model to observe wound closure and tissue regeneration over 14 days. Results The PN-HA mixture demonstrated superior mechanical stability compared to individual components. In vitro, PN-HA significantly enhanced HDF and HaCaT migration, proliferation, and upregulated VEGF, MMP-9, and MMP-10 expression. In vivo, PN-HA treatment accelerated wound closure, improved dermal thickness, and enhanced ECM remodeling, as evidenced by histological analyses. Conclusion The PN-HA combination synergistically accelerates wound healing by promoting angiogenesis, cellular migration, and ECM remodeling. These findings highlight its potential as an advanced wound dressing for a…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PN-HA treatments are well-tolerated and effective for repairing the skin barrier.
“PN-HA treatments are well-tolerated and effective for repairing the skin barrier [33,35,41].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [35]
PN contributes to restoring the structural integrity and physiological function of the skin.
“Additionally, PN contributes to restoring the structural integrity and physiological function of the skin, and its effects are often amplified when used in combination with hyaluronic acid (HA) [35,36].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [35]
PN's effects are often amplified when used in combination with hyaluronic acid.
“Additionally, PN contributes to restoring the structural integrity and physiological function of the skin, and its effects are often amplified when used in combination with hyaluronic acid (HA) [35,36].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [35]
PNs are often combined with other biocompatible polymers, such as HA, poly-L-lactic acid, or various bioactive compounds, to achieve synergistic effects on skin texture and rejuvenation outcomes.
“PNs are often combined with other biocompatible polymers, such as HA, poly-L-lactic acid, or various bioactive compounds, to achieve synergistic effects on skin texture and rejuvenation outcomes [21,24,31,32,33,34,35,40,41,42,150].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [35]
Cites
Reinke, J. M., & Sorg, H. (2012) · European Surgical Research · doi:10.1159/000339613 · Cited by 1,898 · see citing works
Kim, J. H., Kwon, T.-R., Lee, S. E., Jang, Y. N., Han, H. S., Mun, S. K., & Kim, B. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-61952-w · Cited by 53 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kim, S. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081024 · Cited by 18 · see citing works
- Authors
- Heo, T.-H., Gu, B. K., Ohk, K., Yoon, J.-K., Son, Y. H., Chun, H. J., Yang, D.-H., & Jeong, G.-J.
- Affiliations
- Chung-Ang University (KR)
- Georgia Institute of Technology (US)
- Catholic University of Korea (KR)
- Corresponding author
- Yang, Dae-Hyeok
- Jeong, Gun-Jae
- Venue
- Tissue Engineering and Regenerative Medicine
- Published
- 2025-02-26
- Volume
- 22
- Issue
- 4
- Pages
- 515-526
- ISSN
- 1738-2696 (ISSN-L)
- 2212-5469
- PMC
- PMC12122959
- OpenAlex
- W4407978009
- Cited by
- 17
- References
- 2
- Citations by year
- 2026: 10 · 2025: 7
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Tissue Engineering and Regenerative Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Funders
- National Research Foundation of Korea (RS-2023-00237493)
- Ministry of Trade, Industry and Energy (20017939, 20022953, RS-2024-00424600, 20026565)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- polynucleotides, hyaluronic acid, wound dressings, accelerated wound healing, hydrogels, angiogenesis, extracellular matrix remodeling, dermal fibroblasts, keratinocytes, vascular endothelial growth factor, matrix metalloproteinases, cell migration, cell proliferation, chronic wounds
- MeSH terms
- Animals, Bandages, Cell Movement, Extracellular Matrix, Fibroblasts, Humans, Hyaluronic Acid, Skin, Wound Healing, Keratinocytes, Matrix Metalloproteinase 9, Vascular Endothelial Growth Factor A, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
