Comparative Evaluation of the Effectiveness of Novel Hyaluronic Acid-Polynucleotide Complex Dermal Filler
Open accessAbstract
HA (Hyaluronic acid) filler, the most commonly used dermal filler, causes several side effects. HA-PN (Hyaluronic acid-Polynucleotide), a new composite filler, has excellent biocompatibility and induces tissue regeneration. In this study, we compare the efficacies and safety profiles of these fillers. The characteristics of HA and HA–PN fillers were compared using scanning electron microscopy and rheometry. No morphological difference was noted between the fillers. However, the latter had higher viscosity and elasticity values. The HA-PN filler induced higher cell migration than the HA filler in a wound healing assay. It was also found to stimulate better collagen synthesis in human and mouse fibroblasts. The HA and HA–PN fillers were injected into SKH1 hairless mice to determine changes in their volume for up to 24 weeks. Increased cell migration and collagen synthesis were observed in mice injected with the HA–PN complex filler. Although the safety and durability of the HA and HA–PN fillers were similar, the latter induced a lower transient receptor potential vanilloid 4 expression and caused less stimulation upon injection. In conclusion, HA–PN complex fillers can stimulate fibroblast growth and facilitate volume growth and skin regeneration.
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PNs are often combined with other biocompatible polymers, such as HA, poly-L-lactic acid, or various bioactive compounds, to achieve synergistic effects on skin texture and rejuvenation outcomes.
“PNs are often combined with other biocompatible polymers, such as HA, poly-L-lactic acid, or various bioactive compounds, to achieve synergistic effects on skin texture and rejuvenation outcomes [21,24,31,32,33,34,35,40,41,42,150].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [40]
The Introduction and Discussion describe an HA–PN filler that combines the benefits of tissue regeneration and durability and reports improved skin-regeneration effects. This paper supports HA as an example, but the passages do not establish that PNs are often combined with other materials or address poly-L-lactic acid or other bioactive compounds. (LLM, conf=0.87)
Experimental — accuracy not yet measuredThe combined use of PN and HA promotes human fibroblast proliferation.
“Kim et al. demonstrated that the combined use of PN and HA promotes human fibroblast proliferation [40].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [40]
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- Authors
- Kim, J. H., Kwon, T.-R., Lee, S. E., Jang, Y. N., Han, H. S., Mun, S. K., & Kim, B. J.
- Affiliations
- Chung-Ang University Hospital (KR)
- Chung-Ang University (KR)
- Corresponding author
- Kim, Beom Joon
- Venue
- Scientific Reports
- Published
- 2020-03-20
- Volume
- 10
- Issue
- 1
- Pages
- 5127-5127
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC7083941
- OpenAlex
- W3012008682
- Cited by
- 53
- References
- 55
- Citations by year
- 2026: 14 · 2025: 14 · 2024: 11 · 2023: 7 · 2022: 3 · 2021: 4
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- hyaluronic acid, polynucleotides, dermal fillers, filler safety, filler durability, collagen synthesis, wound healing, skin regeneration
- MeSH terms
- Dermal Fillers, Animals, Biocompatible Materials, Cell Line, Cell Movement, Collagen, Cosmetic Techniques, Fibroblasts, Humans, Hyaluronic Acid, Mice, Hairless, Polynucleotides, Skin, Skin Physiological Phenomena, Wound Healing, TRPV Cation Channels, Mice
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