Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland
Open accessAbstract
Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15–77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%.
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The clinical utility of caspofungin is increasingly compromised by emergence of non-susceptible strains.
“However, the clinical utility of caspofungin is increasingly compromised by the emergence of non‐susceptible strains [5, 6].”
From Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in <i>Candida Glabrata</i> (2026) · cites this paper as [5]
The distribution of these carbohydrate molecules across dynamically distinct phases, as demonstrated in the SC5314 strain, was consistently observed in the spectra of other C. albicans strains, including JKC1450, JCK1583, JKC302, as well as BS1 strains.
“It should be noted that distribution of these carbohydrate molecules across dynamically distinct phases, as demonstrated in the SC5314 strain, was consistently observed in the spectra of other C. albicans strains, including JKC1450, JCK1583, JKC302, as well as BS1 strains (Supplementary Fig. 1)66.”
From Distinct echinocandin responses of Candida albicans and Candida auris cell walls revealed by solid-state NMR (2025) · cites this paper as [66]
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- Authors
- Coste, A. T., Kritikos, A., Li, J., Khanna, N., Goldenberger, D., Garzoni, C., Zehnder, C., Boggian, K., Neofytos, D., Riat, A., Bachmann, D., Sanglard, D., Lamoth, F., The Fungal Infection Network of Switzerland (FUNGINOS), Lamoth, F., Khanna, N., Boggian, K., & Sanglard, D.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- University of Basel (CH)
- Clinica Luganese Moncucco (CH)
- University Hospital of Geneva (CH)
- Venue
- Infection
- Published
- 2020-07-13
- Volume
- 48
- Issue
- 5
- Pages
- 761-766
- ISSN
- 0300-8126 (ISSN-L)
- 1439-0973
- PMC
- PMC7518979
- OpenAlex
- W3043323594
- Cited by
- 69
- References
- 13
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 16 · 2023: 12 · 2022: 11 · 2021: 11 · 2020: 3
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Infection (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, cc-by)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- IRIS (submittedVersion, cc-by)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- FUNGINOS
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- echinocandin resistance, Candida albicans, Candida glabrata, candidemia, antifungal resistance, persistent candidemia, mortality, Switzerland
- MeSH terms
- Adult, Aged, Aged, 80 and over, Antifungal Agents, Candida albicans, Female, Humans, Male, Middle Aged, Switzerland, Drug Resistance, Fungal, Candida glabrata, Echinocandins, Candidemia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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