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Cited by 416

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Microneedle for transdermal drug delivery: current trends and fabrication

Open access
Jung, Jae Hwan, Jin, Sung Giu·2021·Journal of Pharmaceutical Investigation

Abstract

Background: Transdermal delivery has the advantage of bypassing the first-pass effect and allowing sustained release of the drug. However, the drug delivery is limited owing to the barrier created by the stratum corneum. Microneedles are a transdermal drug delivery system that is painless, less invasive, and easy to self-administer, with a high drug bioavailability. Area covered: The dose, delivery rate, and efficacy of the drugs can be controlled by the microneedle design and drug formulations. This review introduces the types of microneedles and their design, materials used for fabrication, and manufacturing methods. Additionally, recent biological applications and clinical trials are introduced. Expert opinion: With advancements made in formulation technologies, the drug-loading capability of microneedles can be improved. 3D printing and digital technology contribute to the improvement of microneedle fabrication technology. However, regulations regarding the manufacture of microneedle products should be established as soon as possible to promote commercialization.

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Metadata

Authors
Jung, J. H., & Jin, S. G.
Venue
Journal of Pharmaceutical Investigation
Published
2021-03-04
Volume
51
Issue
5
Pages
503-517
ISSN
  • 2093-5552 (ISSN-L)
  • 2093-6214
OpenAlex
W3135864047
Cited by
416
References
1
FWCI
20.85
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Microneedle for transdermal drug delivery: current trends and fabrication. https://app.cochat.ai/papers/10.1007/s40005-021-00512-4
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Jung, J. H., & Jin, S. G. (2021). Microneedle for transdermal drug delivery: current trends and fabrication. Journal of Pharmaceutical Investigation. https://doi.org/10.1007/s40005-021-00512-4

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.