Cited by 78Advancements in Transdermal Drug DeliverySurfactants and Colloidal SystemsDrug Solubulity and Delivery Systems

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Investigation of effect of non-ionic surfactant on preparation of griseofulvin non-aqueous nanoemulsion

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Jadhav, Chaitali, Kate, Vaishali, Payghan, Santosh A.·2015·Journal of nanostructure in chemistry

DOI 10.1007/s40097-014-0141-y

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Abstract

Generally emulsions are water-in-oil or oil-in-water type, but emulsions may contain polar liquid as one of the phase. Non-aqueous emulsions are useful in many situations where presence of water is not desirable, and formulation of active ingredients which undergo hydrolysis or oxidation in the presence of water. The study was to design a stable non-aqueous nanoemulsion (NANE) using cosmetically approved ingredients as a vehicle for the water-sensitive active ingredients. Non-aqueous nanoemulsion was designed to increase the dermal penetration and permeation and study solubility and dermal bioavailability of griseofulvin. For better compliance, the NANEs will be incorporated in cosmetics or personal care products. A non-aqueous system was obtained with glycerin and olive oil stabilized by glycerol monosterate with co-surfactant. It was observed that emulsification behavior is completely unpredictable and conventional theories of emulsification and HLB system cannot be applied here. An optimized NANE was obtained through implementation of pseudo-ternary phase diagram. Pseudo-ternary phase diagram was constructed using surfactant and co-surfactant ratio (1:1, 2:1, 3:1, 4:1) and nanoemulsion region was determined and further characterized for pH, rheology, globule size analysis, zeta potential and stability. Stability studies (agitation, centrifugation, freeze thaw cycle, accelerated stability) were carried out at 5, 25 and 40 °C. Cream was stable at 5 and 25. Results proved that NANE can be used as vehicle for the poorly water-soluble drug, suspension vehicles and oleogels.

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Authors: Jadhav, C., Kate, V., & Payghan, S. A.
Corresponding author: Payghan, Santosh A.
ORCID: Payghan, Santosh A.
Venue: Journal of nanostructure in chemistry
Publisher: Springer Science and Business Media LLC
Published: 2014-12-18
Volume: 5
Issue: 1
Pages: 107-113
ISSN: 2008-9244 (ISSN-L)
2193-8865
DOI: 10.1007/s40097-014-0141-y
OpenAlex: W2068504124
Cited by: 78
References: 22
Citations by year: 2026: 3 · 2025: 2 · 2024: 11 · 2023: 7 · 2022: 9 · 2021: 12 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 8 · 2015: 2
FWCI: 2.84
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: Journal of nanostructure in chemistry (publishedVersion, cc-by)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords: griseofulvin, nonionic surfactants, glyceryl monostearate, pseudo-ternary phase diagram, emulsion stability, skin penetration, poorly water-soluble drugs, emulsification, rheology, zeta potential, globule size, cosmetic formulation, personal care products

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Investigation of effect of non-ionic surfactant on preparation of griseofulvin non-aqueous nanoemulsion

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