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Cited by 25Multiple Myeloma Research and TreatmentsBone health and treatmentsProtein Degradation and Inhibitors

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Pomalidomide: A Review in Relapsed and Refractory Multiple Myeloma

Hoy, Sheridan M.·2017·Drugs
DOI 10.1007/s40265-017-0833-y
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Abstract

Pomalidomide (Imnovid®; Pomalyst®), an analogue of thalidomide, is an immunomodulatory agent, with several mechanisms of action (both direct and indirect) thought to be involved in its anti-myeloma activity. Oral pomalidomide is available in several countries for use in combination with low-dose dexamethasone in adults with relapsed and refractory multiple myeloma. In multinational, phase II or III studies in patients with refractory, or relapsed and refractory multiple myeloma who had received ≥ 2 prior treatment regimens (including ≥ 2 cycles of both lenalidomide and bortezomib), pomalidomide plus low-dose dexamethasone was associated with prolonged progression-free survival (PFS) and overall survival and an improved overall response rate. Pomalidomide plus low-dose dexamethasone had a manageable tolerability profile, with neutropenia, infections, anaemia and thrombocytopenia being the most frequently reported grade 3 or 4 treatment-emergent adverse events. In conclusion, pomalidomide plus low-dose dexamethasone extends the treatment options available for the management of relapsed and refractory multiple myeloma in a patient population that has very limited treatment options.

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Citations

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Research works printed but not linked: 26

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Metadata

Authors
Hoy, S. M.
Affiliations
Springer Nature (New Zealand) (NZ)
Corresponding author
Hoy, Sheridan M.
Venue
Drugs
Publisher
Springer Science and Business Media LLC
Published
2017-11
Volume
77
Issue
17
Pages
1897-1908
ISSN
  • 0012-6667 (ISSN-L)
  • 1179-1950
DOI
10.1007/s40265-017-0833-y
OpenAlex
W2767903236
Cited by
25
References
2
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 2
FWCI
0.30
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (unspecified)
Locations
  • Drugs (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
  • Health Sciences › Medicine › Oncology › Bone health and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
Keywords
pomalidomide, relapsed/refractory multiple myeloma, low-dose dexamethasone, immunomodulators, thalidomide analogues, progression-free survival, overall survival, treatment-emergent adverse events, neutropenia, lenalidomide, bortezomib
MeSH terms
Adult, Antineoplastic Combined Chemotherapy Protocols, Dexamethasone, Dose-Response Relationship, Drug, Female, Humans, Male, Multiple Myeloma, Recurrence, Thalidomide, Treatment Failure, Disease-Free Survival

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