Cited by 381Multiple Myeloma Research and TreatmentsProtein Degradation and InhibitorsBone health and treatments

Pomalidomide alone or in combination with low-dose dexamethasone in relapsed and refractory multiple myeloma: a randomized phase 2 study

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Richardson, Paul G., Siegel, David S., Vij, Ravi, Hofmeister, Craig C., Baz, Rachid, Jagannath, Sundar, Chen, Christine, Lonial, Sagar +16 more·2014·Blood

Abstract

Key Points: Pomalidomide plus low-dose dexamethasone significantly improved PFS vs pomalidomide alone in relapsed and refractory multiple myeloma. Pomalidomide plus low-dose dexamethasone is an important new treatment option for RRMM patients who have received multiple prior therapies.

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Crossref · 10.1182/blood-2013-11-538835

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44 of 44 references verified0 citation errors · 0 not checkable

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  • In vitro studies support the hypothesis that thalidomide analogues synergize with dexamethasone, proteasome inhibitors, histone deacetylase inhibitors and a variety of other agents.

    “Data from a number of in vitro studies support the hypothesis that thalidomide analogues synergize with dexamethasone49,50, proteasome inhibitors51,52, histone deacetylase inhibitors53,54 and a variety of other agents”

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Research works printed but not linked: 1

  1. [6]Rychack E, Mendy D, Miller K, et al. Overcoming resistance; the use of pomalidomide (POM) and dexamethasone (DEX) in re-sensitizing lenalidomide (LEN)-resistant multiple myeloma (MM) cells. Haematologica. 2011;96(Suppl 1):S126. Abstract P-328. [Google Scholar]

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Authors
Richardson, P. G., Siegel, D. S., Vij, R., Hofmeister, C. C., Baz, R., Jagannath, S., Chen, C., Lonial, S., Jakubowiak, A., Bahlis, N., Song, K., Belch, A., Raje, N., Shustik, C., Lentzsch, S., Lacy, M., Mikhael, J., Matous, J., Vesole, D., Chen, M., Zaki, M. H., Jacques, C., Yu, Z., & Anderson, K. C.
Affiliations
  • Dana-Farber Cancer Institute (US)
  • Hackensack University Medical Center (US)
  • Washington University in St. Louis (US)
  • The Ohio State University (US)
  • Moffitt Cancer Center (US)
  • Mount Sinai Medical Center, New York, NY;
  • Princess Margaret Cancer Centre (CA)
  • Emory University (US)
  • University of Chicago Medical Center (US)
  • University of Calgary (CA)
  • Vancouver General Hospital (CA)
  • University of Alberta (CA)
  • Massachusetts General Hospital (US)
  • Royal Victoria Hospital (CA)
  • Columbia University (US)
  • Mayo Clinic (US)
  • Colorado Blood Cancer Institute (US)
  • Celgene (United States) (US)
Venue
Blood
Published
2014-03-20
Volume
123
Issue
12
Pages
1826-1832
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2091773528
Cited by
381
References
43
Citations by year
2026: 7 · 2025: 11 · 2024: 17 · 2023: 14 · 2022: 39 · 2021: 30 · 2020: 31 · 2019: 24 · 2018: 30 · 2017: 54 · 2016: 48 · 2015: 48 · 2014: 27
FWCI
41.83
Type
journal article
Language
en
Update notices
erratum (2014-05-15)
Open access
Locations
  • Blood (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Celgene
  • National Cancer Institute (P50CA100707, P01CA155258, P30CA016058)
Topics
  • Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
  • Health Sciences › Medicine › Oncology › Bone health and treatments
Keywords
pomalidomide, low-dose dexamethasone, relapsed/refractory multiple myeloma, progression-free survival, lenalidomide-refractory disease, bortezomib resistance, combination therapy, neutropenia, peripheral neuropathy, overall survival, overall response rate
MeSH terms
Bortezomib, Lenalidomide, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Boronic Acids, Dexamethasone, Female, Humans, Immunologic Factors, Male, Middle Aged, Multiple Myeloma, Neoplasm Recurrence, Local, Neutropenia, Pyrazines, Thalidomide, Treatment Outcome, Disease-Free Survival, Drug Resistance, Neoplasm

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