Denosumab: A review in postmenopausal osteoporosis
Abstract
Denosumab (Prolia ® ; Pralia ® ) is a human monoclonal antibody targeting the key bone resorption mediator RANKL. The drug is administered via subcutaneous injection once every 6 months and is approved for various indications, including the treatment of postmenopausal (PM) women with osteoporosis at increased/high risk of fracture or failure/intolerance of other osteoporosis therapies (indications featured in this review). Denosumab showed benefit in several phase 3 or 4 studies in PM women with osteoporosis or low bone mineral density (BMD), including the pivotal 3-year double-blind FREEDOM trial and its 7-year open-label extension. Denosumab reduced the risk of vertebral, nonvertebral and hip fractures and increased BMD across skeletal sites versus placebo in FREEDOM, with these benefits maintained over up to 10 years' therapy in the extension. The drug was also more effective in improving BMD than bisphosphonates, including in women switched from a bisphosphonate regimen, in 1-year trials; however, whether these differences translate into differences in anti-fracture efficacy is unclear. Denosumab was generally well tolerated over up to 10 years' treatment, although an increased risk of multiple vertebral fractures was observed after discontinuation of the drug. Thus, denosumab is a key treatment option for PM women with osteoporosis who have an increased/high risk of fracture or failure/intolerance of other osteoporosis therapies, although the potential for multiple verte…
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Denosumab has undesirable side effects and, similar to bisphosphonates, adversely affects osteoblastogenesis.
“denosumab, has been shown to have undesirable side effects and, similar to biphosphonates, adversely affects osteoblastogenesis [71]”
From Osteoclasts and Microgravity (2020) · cites this paper as [71]
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- Authors
- Deeks, E. D.
- Affiliations
- Springer Nature (New Zealand) (NZ)
- Corresponding author
- Deeks, Emma D.
- Venue
- Drugs & Aging
- Published
- 2018-02
- Volume
- 35
- Issue
- 2
- Pages
- 163-173
- ISSN
- 1170-229X (ISSN-L)
- 1179-1969
- OpenAlex
- W2792392055
- Cited by
- 169
- References
- 55
- Citations by year
- 2026: 7 · 2025: 23 · 2024: 16 · 2023: 22 · 2022: 32 · 2021: 37 · 2020: 19 · 2019: 10 · 2018: 3
- FWCI
- 18.74
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-03-09)
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Drugs & Aging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- denosumab, postmenopausal osteoporosis, RANKL, monoclonal antibodies, fracture risk, vertebral fractures, hip fracture, osteopenia, FREEDOM trial, drug discontinuation, adverse events, long-term treatment
- MeSH terms
- Denosumab, Aged, Clinical Trials as Topic, Female, Humans, Bone Density, Osteoporosis, Postmenopausal, Treatment Outcome, Bone Density Conservation Agents, Fractures, Bone, RANK Ligand
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