LncRNA H19 Overexpression in Endometriosis and its Utility as a Novel Biomarker for Predicting Recurrence
Abstract
Endometriosis has a high recurrence rate after treatment, and there are no effective recurrence predictors. LncRNA H19 has been found to be a predictor of the poor prognosis of multiple diseases. Here, we aimed to investigate the expression and clinical implications of lncRNAH19 in endometriosis and explore the clinical application value of lncRNAH19 for recurrence prediction. LncRNA H19 expression was evaluated in 104 ectopic and eutopic endometrial samples from patients with endometriosis and 50 control endometrial samples from patients without endometriosis. The association between lncRNA H19 expression and the clinical characteristics of endometriosis as well as its value as a potential predictor of recurrence were analyzed. LncRNA H19 expression in the ectopic and eutopic endometria of endometriosis patients was significantly higher than that in the normal endometrium. LncRNA H19 expression in the ectopic endometrium was associated with infertility, recurrence, bilateral ovarian lesions, an increased CA125 level, and revised American Fertility Society (rAFS) stage. Multivariate logistic regression analysis showed that age less than 40 years and lncRNA H19 overexpression in the ectopic endometrium were independent prognostic factors of endometriosis recurrence, and the receiver operating characteristic (ROC) curve showed that the sensitivity and specificity for predicting recurrence were 90.9% and 61.0%, respectively, when the lncRNA H19 expression level in the ectopic endometrium was higher than 0.0277. LncRNA H19 may be involved in the pathogenesis of endometriosis especially in the mechanism of recurrence and is a novel potential predictor of the recurrence of endometriosis.
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Zhou et al. found that 388 lncRNA transcripts were overexpressed and 188 showed decreased expression in ectopic endometrium compared to eutopic endometrium.
“Zhou et al. found that 388 transcripts of lncRNA tested showed overexpression and 188 showed decreased expression levels in the ectopic endometrium compared to eutopic endometrium [172].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [172]
LncRNA H19 may be involved in the pathogenesis of endometriosis, especially in the mechanism of recurrence, and is a novel potential predictor of recurrence; its expression in ectopic and eutopic endometria of endometriosis patients was significantly higher than in normal endometrium.
“Liu et al. showed that LncRNA H19 may be involved in the pathogenesis of endometriosis especially in the mechanism of recurrence and is a novel potential predictor of the recurrence of endometriosis. In this study LncRNA H19 expression in the ectopic and eutopic endometria of endometriosis patients was significantly higher than that in the normal endometrium [172].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [172]
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- Authors
- Liu, S., Xin, W., Tang, X., Qiu, J., Zhang, Y., & Hua, K.
- Affiliations
- Fudan University (CN)
- Venue
- Reproductive Sciences
- Published
- 2020-05-28
- Volume
- 27
- Issue
- 9
- Pages
- 1687-1697
- ISSN
- 1933-7191 (ISSN-L)
- 1933-7205
- OpenAlex
- W3030082703
- Cited by
- 31
- References
- 37
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 11 · 2022: 6 · 2021: 4
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- endometriosis, H19, long non-coding RNA, endometriosis recurrence, ectopic endometrium, eutopic endometrium, infertility, CA125, prognostic factors
- MeSH terms
- Adult, Endometriosis, Endometrium, Female, Humans, Middle Aged, Recurrence, Biomarkers, Case-Control Studies, Young Adult, RNA, Long Noncoding
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