Plasma renin substrate, renin activity, and aldosterone levels in a sample of oral contraceptive users from a community survey
Abstract
Fasting plasma renin substrate (PRS), plasma renin activity (PRA), plasma aldosterone (PA), and blood pressure (BP) levels were measured from 212 apparently healthy normotensive nonpregnant white women aged 21 to 39 years, selected on the basis of oral contraceptive (OC) use of nonuse in 1976 following a community survey in East Boston. The mean PRS level was 7118 ng/dl among OC users and 1935 ng/dl among nonusers (p less than 0.0001). In contrast, mean PRA was 2.9 ng of angiotensin 1 per milliliter per hour among users and 3.0 ng of angiotensin l/ml/hr among nonusers (p = NS); mean PA levels were 26.2 ng/dl and 25.4 ng/dl, respectively (p = NS). Mean systolic BPs were 113.8 mm Hg among current OC users and 111.2 mm Hg among nonusers (p = 0.078); diastolic BPs were 68.5 and 68.9, respectively (p = NS). These data indicate a greater than three-fold increase in PRS among current OC users compared to nonusers, with virtually identical PRA and PA levels. The data indicate that normotensive women using OCs maintain normal PRA and PA levels despite marked elevations in PRS.
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Estrogen replacement therapy and hormone replacement therapy appear to have a neutral effect on blood pressure.
“Estrogen replacement therapy and hormone replacement therapy appear to have a neutral effect on BP, as illustrated by the following observations from 2 large randomized trials.”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [211]
The Women's Health Initiative found that at 5.2 years hormone replacement therapy produced only a small increase (1.5 mm Hg) in systolic blood pressure compared with placebo.
“The Women’s Health Initiative, a randomized placebo-controlled trial, assessed the effect of estrogen-progestin replacement on outcomes in postmenopausal women211 and found that at 5.2 years hormone replacement therapy produced only a small increase (1.5 mm Hg) in SBP compared with placebo.212”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [211]
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- Authors
- Goldhaber, S. Z., Hennekens, C. H., Spark, R. F., Evans, D. A., Rosner, B., Taylor, J. O., & Kass, E. H.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Goldhaber, Samuel Z.
- Venue
- American Heart Journal
- Publisher
- Elsevier BV
- Published
- 1984-01
- Volume
- 107
- Issue
- 1
- Pages
- 119-122
- ISSN
- 0002-8703 (ISSN-L)
- OpenAlex
- W1977312708
- Cited by
- 45
- References
- 40
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- oral contraceptives, plasma renin substrate, renin-angiotensin system, plasma renin activity, plasma aldosterone, blood pressure, normotensive women, East Boston
- MeSH terms
- Adult, Aldosterone, Angiotensinogen, Angiotensins, Blood Pressure, Contraceptives, Oral, Female, Health Surveys, Humans, Renin, Renin-Angiotensin System
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