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Percutaneous transluminal balloon pulmonary valvuloplasty for the relief of pulmonary valve stenosis with special reference to double-balloon technique
Abstract
PTBPV was performed 33 times in 32 patients in the Riyadh Armed Forces Hospital. Patients ranged in age from 6 months to 12 years (mean 4.5 years); average weight was 14.86 kg. Before dilatation, all patients had grade 4/6 late peaking systolic ejection murmurs, with right-axis deviation and right ventricular hypertrophy on ECG. Moderate to severe pulmonary valve stenosis (right ventricle-pulmonary artery gradient 50 mm Hg systolic) was confirmed both hemodynamically and angiographically. Balloon size was selected to be approximately 2 mm larger than the pulmonary valve anulus was over 25 were inflated to approximately 5 atmospheres of pressure. Two patients required two simultaneous balloons as the pulmonary valve anulus was over 25 mm. Predilatation peak systolic pressure gradients ranged from 50 to 245 mm Hg (mean 99.2 mm Hg); postdilatation gradients ranged from 8 to 93 mm Hg (mean 23.4 mm Hg). There were no deaths or complications. The systolic murmur with early systolic peak decreased in all but three patients. Systolic thrill disappeared in all but three patients. Follow-up at an average of 10 months revealed increasing exercise tolerance in two thirds of patients. Fourteen patients have been recatheterized at least 6 months after dilatation and showed persistent minimal gradient. We conclude that balloon valvuloplasty of pulmonary valve stenosis is an effective, safe procedure. At this writing, a total of 90 successful PTBPVs have been performed, with equally impressi…
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Microglia and astrocytes coordinate their functions in many ways, both in the healthy and diseased brain.
“However, recent data indicate that microglia and astrocytes coordinate their functions in many ways, both in the healthy and diseased brain [14–21].”
From Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates (2021) · cites this paper as [14]
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Research works printed but not linked: 22
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Rostami, J., Mothes, T., Kolahdouzan, M., Eriksson, O., Moslem, M., Bergström, J., Ingelsson, M., O’Callaghan, P., Healy, L. M., Falk, A., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02158-3 · Cited by 224
Metadata
- Authors
- Ali Khan, M. A., Yousef, S. A., & Mullins, C. E.
- Affiliations
- Riyadh Armed Forces Hospital (SA)
- Venue
- American Heart Journal
- Publisher
- Elsevier BV
- Published
- 1986-07
- Volume
- 112
- Issue
- 1
- Pages
- 158-166
- ISSN
- 0002-8703 (ISSN-L)
- OpenAlex
- W2066760774
- Cited by
- 73
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 1 · 2020: 1 · 2016: 2 · 2014: 1 · 2012: 1
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Keywords
- pulmonary valve stenosis, double balloon technique, pediatric patients, right ventricular pressure gradient, exercise tolerance, procedural safety
- MeSH terms
- Angioplasty, Balloon, Child, Child, Preschool, Evaluation Studies as Topic, Female, Follow-Up Studies, Heart Murmurs, Hemodynamics, Humans, Infant, Male, Pulmonary Valve, Pulmonary Valve Stenosis, Radiography
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