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Cited by 81Cardiac electrophysiology and arrhythmiasAcute Myocardial Infarction ResearchCardiac Ischemia and Reperfusion

Time-related changes in the Q-T interval in acute myocardial infarction: possible relation to local hypocalcemia

Doroghazi, Robert M., Childers, Rory·1978·The American Journal of Cardiology
DOI 10.1016/0002-9149(78)90818-4
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Abstract

In 63 patients with either acute transmural or nontransmural myocardial infarction, the Q-T interval was prolonged beyond normal limits on at least 1 of the 5 days after infarction in 27 patients (8 with transmural and 19 with nontransmural infarction). The time-related changes in the corrected Q-T (Q-Tc) interval were defined for the entire sample and showed significant expansion, maximal on day 2, from a preinfarction control value. By day 5, the Q-Tc interval was no longer significantly prolonged and was not expanded beyond normal limits in any patient. Various possible causes of Q-T prolongation in myocardial infarction are local hypothermia, local conduction delay, neurogenic effect and local hypocalcemia. Collateral evidence suggests that the letter may contribute significantly to prolongation.

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Crossref · 10.1016/0002-9149(78)90818-4

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Authors
Doroghazi, R. M., & Childers, R.
Affiliations
University of Chicago (US)
Corresponding author
Childers, Rory
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1978-04
Volume
41
Issue
4
Pages
684-688
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/0002-9149(78)90818-4
OpenAlex
W2088776880
Cited by
81
References
42
Citations by year
2025: 1 · 2024: 1 · 2021: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2012: 1
FWCI
4.71
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Keywords
QT interval, QTc interval, acute myocardial infarction, transmural infarction, nontransmural infarction, local hypothermia, conduction delay
MeSH terms
Action Potentials, Calcium, Electrocardiography, Heart Conduction System, Humans, Myocardial Contraction, Myocardial Infarction, Time Factors, Water-Electrolyte Balance

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