CoChat
Sign Up
Cited by 132Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlCardiac electrophysiology and arrhythmias

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Neurally mediated syncope detected by carotid sinus massage and head-up tilt test in sick sinus syndrome

Brignole, Michele, Menozzi, Carlo, Gianfranchi, Lorella, Oddone, Daniele, Lolli, Gino, Bertulla, Antonio·1991·The American Journal of Cardiology
DOI 10.1016/0002-9149(91)90491-3
Open this paper in CoChat — free account

Abstract

It is generally accepted that a positive response to carotid sinus massage (CSM) or head-up tilt (HUT) in patients affected by syncope suggests a reflex cause of the syncope. To study the role of the autonomic nervous system in causing syncope in the sick sinus syndrome (SSS), CSM and HUT were performed in 35 consecutive patients (20 men, mean age 70 +/- 9 years) with syncope and SSS. Results were compared with those in 35 patients affected by syncope that, despite careful cardiovascular and neurologic examination, were of uncertain origin (21 men; mean age 68 +/- 9 years) and with those of 35 subjects without syncope (20 men; mean age 69 +/- 10). All patients underwent CSM in the supine and standing positions for 10 seconds and HUT to 60 degrees for 60 minutes. In the patients with SSS, the full reproduction of spontaneous symptoms by CSM occurred in 21 (60%) and by HUT, in 19 (54%). At least 1 test was positive in 28 patients (80%): cardioinhibitory or mixed responses in 69%, vasodepressor responses in 11%. The percentages of positive tests in the patients with syncope of uncertain origin were similar to or slightly less than those of patients with SSS (CSM 63%, HUT 26%, overall 74%) with cardioinhibitory or mixed responses in 54% and vasodepressor in 20% (p less than 0.05). In control subjects, syncope was induced by CSM in 1 (3%) and by HUT in 2 (6%); overall positivity was 9%. In conclusion, in most patients affected by syncope and SSS, an abnormal neural reflex probably plays a major role in causing syncope.(ABSTRACT TRUNCATED AT 250 WORDS)

Overview

Integrity signals

Registry

Crossref · 10.1016/0002-9149(91)90491-3

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 22 references

Research works printed but not linked: 1

  1. Kaseda, 1988, Vagal denervation of canine sinus and atrioventricular nodes creates supersensitive response to acetylcholine (abstr), J Am Coll Cardiol, 11, 39A

Cited by

Sorted by citations

Items 101–132 of 132

Related

See all

Metadata

Authors
Brignole, M., Menozzi, C., Gianfranchi, L., Oddone, D., Lolli, G., & Bertulla, A.
Affiliations
Presidio Ospedaliero (IT)
ORCID
Brignole, Michele
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1991-10
Volume
68
Issue
10
Pages
1032-1036
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/0002-9149(91)90491-3
OpenAlex
W2127225262
Cited by
132
References
22
Citations by year
2025: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 5 · 2016: 2 · 2014: 2 · 2013: 5 · 2012: 6
FWCI
4.36
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
syncope, sick sinus syndrome, carotid sinus massage, head-up tilt, neurogenic syncope, autonomic nervous system, cardioinhibitory response, vasodepressor response, neural reflexes
MeSH terms
Aged, Autonomic Nervous System, Carotid Sinus, Female, Humans, Male, Posture, Reflex, Sick Sinus Syndrome, Syncope

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review