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Cited by 49Acute Myocardial Infarction ResearchBlood Coagulation and Thrombosis MechanismsAcute Ischemic Stroke Management

Association of patency of the infarct-related coronary artery with plasma levels of plasminogen activator inhibitor activity in acute myocardial infarction

Sakamoto, Tomohiro, Yasue, Hirofumi, Ogawa, Hisao, Misumi, Ikuo, Masuda, Takenobu·1992·The American Journal of Cardiology
DOI 10.1016/0002-9149(92)90603-v
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Abstract

To examine the fibrinolytic capacity in patients with acute myocardial infarction (AMI), baseline levels of plasma plasminogen activator inhibitor (PAI) activity and tissue-type plasminogen activator (t-PA) antigen were measured in 47 patients with Q-wave AMI who underwent emergent coronary angiography 3.0 +/- 0.2 hours after the symptom onset. They received intracoronary injection of urokinase if their infarct-related arteries were occluded. They were classified into 3 groups according to the patency of the infarct-related artery before and after thrombolytic therapy: the patent group (13 patients), the recanalized group (23 patients) and the occluded group (11 patients). The mean level of plasma PAI activity (IU/ml) was higher in patients with AMI as a whole than in the control group (12.8 +/- 1.6 vs 5.4 +/- 0.5, p less than 0.01). The level was lower in the patent group (3.0 +/- 1.1) and higher in the recanalized (18.6 +/- 2.2) and occluded (10.8 +/- 2.5) groups than in the control group (each p less than 0.01). The level was lower in the occluded than in the recanalized group (p less than 0.01) and 62% of the patients in the occluded group had levels within range of the control group. The mean level of plasma t-PA antigen (ng/ml) was higher in patients with AMI as a whole than in the control group (10.3 +/- 0.8 vs 5.8 +/- 0.3, p less than 0.01). There was no difference in the level among the 3 groups with AMI.(ABSTRACT TRUNCATED AT 250 WORDS)

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  • In recent reports on the association of CRP and fibrinogen with mean IMT and coronary artery calcium score in Japanese, Japanese-American, and Caucasian populations, a significant association was not seen in any of the races after adjustment for multiple variables or for age and BMI.

    “By contrast, some recent reports on the association of CRP and fibrinogen with mean IMT and coronary artery calcium score in the Japanese, Japanese–American, and Caucasian populations have stated that a significant association was not seen in any of the races after adjustment for multiple variables (age, SBP, LDL-C, HDL-C, fasting glucose level, smoking, and alcohol consumption) or for age and BMI”

    From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [301]

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Authors
Sakamoto, T., Yasue, H., Ogawa, H., Misumi, I., & Masuda, T.
Affiliations
Kumamoto University (JP)
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1992-08
Volume
70
Issue
3
Pages
271-276
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/0002-9149(92)90603-v
OpenAlex
W2051364696
Cited by
49
References
26
Citations by year
2023: 1 · 2021: 1 · 2018: 1 · 2014: 2 · 2012: 1
FWCI
4.40
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education
  • Smoking Research Foundation
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords
acute myocardial infarction, plasminogen activator inhibitor, tissue plasminogen activator, fibrinolysis, coronary recanalization, coronary artery occlusion, urokinase thrombolysis, Q-wave myocardial infarction
MeSH terms
Adult, Aged, Aged, 80 and over, Antigens, Arteries, Coronary Vessels, Female, Humans, Male, Middle Aged, Myocardial Infarction, Tissue Plasminogen Activator, Urokinase-Type Plasminogen Activator, Vascular Patency, Plasminogen Inactivators, Thrombolytic Therapy, Coronary Angiography

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