Systemic hypertension associated with tricyclic antidepressant treatment in patients with panic disorder
Abstract
In a sample of 114 patients, 6 patients developed hypertension while taking tricyclic antidepressants. All these patients were diagnosed as having panic disorder, with or without major depression. Half of the 6 patients had a previous diagnosis of hypertension, which had been well controlled by antihypertensive drugs for years. A comparison group of patients with major depression, who had never had panic attacks, had no cases of hypertension induced by these antidepressants. These findings raise the possibility that patients who have panic disorder may experience cardiovascular disregulation that increases their risk for antidepressant-induced hypertension.
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Tricyclic antidepressants have been found to increase blood pressure in patients with panic disorders.
“Tricyclic antidepressants have been found to increase BP in patients with panic disorders.246”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [246]
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Carey, R. M., Calhoun, D. A., Bakris, G. L., Brook, R. D., Daugherty, S. L., Dennison-Himmelfarb, C. R., Egan, B. M., Flack, J. M., Gidding, S. S., Judd, E., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000084 · Cited by 1,153 · see citing works
- Authors
- Louie, A. K., Louie, E. K., & Lannon, R. A.
- Affiliations
- Loyola University Medical Center (US)
- Corresponding author
- Louie, Alan K.
- ORCID
- Louie, Alan K.
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 1992-11
- Volume
- 70
- Issue
- 15
- Pages
- 1306-1309
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2000502229
- Cited by
- 25
- References
- 19
- Citations by year
- 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 1
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k11mh000582-02)
- National Institute of Mental Health (MH-00582)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- tricyclic antidepressants, hypertension, panic disorder, cardiovascular dysregulation, major depressive disorder, adverse drug reactions
- MeSH terms
- Adult, Antidepressive Agents, Tricyclic, Female, Humans, Hypertension, Male, Panic Disorder
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