The DOI matches its Crossref record; 52 of the 55 references it cites were found in a registry or an index.
Catecholamine sensitivity, thyroid hormone and the heart
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Sympatho-adrenal stimulation could thus contribute to sustain BP levels during acute hypothyroidism as a possible mechanism counteracting the decrease in myocardial inotropism and cardiac output (4,14,15).”
From The Role of Thyroid Hormone in Blood Pressure Homeostasis: Evidence from Short-Term Hypothyroidism in Humans (2002) · cites this paper as [14]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“in the hyperthyroid state the increase in renin release secondary to the hormone-dependent decrease in systemic vascular resistance may stimulate the angiotensin-aldosterone axis and consequently sodium reabsorption (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23).”
From The Role of Thyroid Hormone in Blood Pressure Homeostasis: Evidence from Short-Term Hypothyroidism in Humans (2002) · cites this paper as [14]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Some Aspects of the Biological Role of Adenosine 3',5'-monophosphate (Cyclic AMP)
Sutherland, E. W., Robison, G. A., & Butcher, R. W. (1968) · Circulation · doi:10.1161/01.cir.37.2.279 · Cited by 962
Murad, F., Chi, Y.-M., Rall, T. W., & Sutherland, E. W. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60314-x · Cited by 550
THE ACTION OF EPINEPHRINE AND THE ROLE OF THE ADENYL CYCLASE SYSTEM IN HORMONE ACTION.
Sutherland, E. W., Oye, I., & Butcher, R. W. (1965) · PubMed · Cited by 423
Buccino, R. A., Spann, J. F., Pool, P. E., Sonnenblick, E. H., & D, E. B. M. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105658 · Cited by 384
Brewster, W. R., Isaacs, J. P., Osgood, P. F., & KING, T. L. (1956) · Circulation · doi:10.1161/01.cir.13.1.1 · Cited by 351
CURRENT TOPICS IN THYROID RESEARCH
Cassano, C., & Andreoli, M. (1966) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196609000-00031 · Cited by 321
The Effect of Epinephrine on Adenosine 3',5'-Phosphate Levels in the Isolated Perfused Rat Heart
Robison, G. A., Butcher, R. W., Øye, I., Morgan, H. E., & Sutherland, E. W. (1965) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14750-0 · Cited by 304
Adrenal Medullary and Thyroid Relationships
Harrison, T. S. (1964) · Physiological Reviews · doi:10.1152/physrev.1964.44.2.161 · Cited by 229
Levey, G. S., & Epstein, S. E. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106131 · Cited by 167
Self-citationEffects of Oral and Intramuscular Administration of Reserpine in Thyrotoxicosis
Canary, J. J., Schaaf, M., Duffy, B. J., & Kyle, L. H. (1957) · New England Journal of Medicine · doi:10.1056/nejm195709052571001 · Cited by 161
Lee, W. Y., Bronsky, D., & Waldstein, S. S. (1962) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-22-9-879 · Cited by 152
Activation of Adenyl Cyclase by Glucagon in Cat and Human Heart
Levey, G. S., & Epstein, S. E. (1969) · Circulation Research · doi:10.1161/01.res.24.2.151 · Cited by 149
Self-citationTHE POTENTIATION OF CARDIAC INOTROPIC RESPONSES TO NOREPINEPHRINE BY THEOPHYLLINE
Rall, T. W., & West, T. C. (1963) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)26490-4 · Cited by 144
Thyroid-Catecholamine Interrelations
Waldstein, S. S. (1966) · Annual Review of Medicine · doi:10.1146/annurev.me.17.020166.001011 · Cited by 139
Effects of Guanethidine on Tri-Iodothyronine-Induced Hyperthyroidism in Man
Gaffney, T. E., D, E. B. M., & Kahler, R. L. (1961) · New England Journal of Medicine · doi:10.1056/nejm196107062650104 · Cited by 109
Thyroid Function and the Cardiac Disposition of Catecholamines
Wurtman, R. J., Kopin, I. J., & Axelrod, J. (1963) · Endocrinology · doi:10.1210/endo-73-1-63 · Cited by 101
Studies on the Metabolism of Aromatic Amines in Relation to Altered Thyroid Function in Man1
Levine, R. J., Oates, J. A., Vendsalu, A., & Sjoerdsma, A. (1962) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-22-12-1242 · Cited by 94
Pharmacodynamic Effects of Beta-Adrenergic Receptor Blockade in Patients with Hyperthyroidism *
Wilson, W. R., Theilen, E. O., & Fletcher, F. W. (1964) · Journal of Clinical Investigation · doi:10.1172/jci105045 · Cited by 83
Wilson, W. R., Theilen, E. O., Hege, J. H., & VALENCA, M. R. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105422 · Cited by 80
van der Schoot, J. B., & Moran, N. C. (1965) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27119-1 · Cited by 76
Influence of beta sympathetic blockade (propranolol) on the hemodynamics of hyperthyroidism
Wiener, L., STOUT, B. D., & Cox, J. W. (1969) · The American Journal of Medicine · doi:10.1016/0002-9343(69)90007-2 · Cited by 72
Margolius, H. S., & Gaffney, T. E. (1965) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27118-x · Cited by 71
Levey, G. S., Skelton, C. L., & Epstein, S. E. (1969) · Endocrinology · doi:10.1210/endo-85-6-1004 · Cited by 60
Self-citationROLE OF THE AUTONOMIC NERVOUS SYSTEM IN THE RESTING TACHYCARDIA OF EXPERIMENTAL HYPERTHYROIDISM
Cairoli, V. J., & Crout, J. R. (1967) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27763-1 · Cited by 60
Urinary Catechol Amines and Their Metabolites in Hyperthyroidism and Hypothyroidism1
WISWELL, J. G., HURWITZ, G. E., Coronho, V., Bing, O. H. L., & CHILD, D. L. (1963) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-23-11-1102 · Cited by 58
Sympathetic Nervous System Blocking in Hyperthyroidism
Vinik, A., PlMSTONE, B. L., & Hoffenberg, R. (1968) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-28-5-725 · Cited by 57
Decreased myocardial adenyl cyclase activity in hypothyroidism
Levey, G. S., Skelton, C. L., & Epstein, S. E. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106190 · Cited by 51
Self-citationTHE EFFECTS OF TRIIODOTHYRONINE ON HEMODYNAMIC RESPONSES TO EPINEPHRINE AND NOREPINEPHRINE IN MAN
Aoki, V. S., Wilson, W. R., Theilen, E. O., Lukensmeyer, W. W., & Leaverton, P. E. (1967) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27679-0 · Cited by 49
RESPONSE OF EXPLANTED CARDIAC MUSCLE TO THYROXINE
Markowitz, C., & Yater, W. M. (1932) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1932.100.1.162 · Cited by 49
THE ESTIMATION OF EPINEPHRINE AND NOREPINEPHRINE IN HUMAN PLASMA*
Goldfien, A., ZILELI, S., Goodman, D. S., & Thorn, G. W. (1961) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-21-3-281 · Cited by 46
The effect of triiodothyronine on cyclic AMP, phosphorylase, and adenyl cyclase in rat heart
McNeill, J. H., Muschek, L. D., & Brody, T. M. (1969) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y69-149 · Cited by 45
Howitt, G., Rowlands, D. J., Leung, D. Y., & Logan, W. F. W. E. (1968) · PubMed · Cited by 43
MURRAY, J. F., & Kelly, J. J. (1959) · Annals of Internal Medicine · doi:10.7326/0003-4819-51-2-309 · Cited by 42
Rosenblum, H. (1933) · Archives of Internal Medicine · doi:10.1001/archinte.1933.00150210109008 · Cited by 39
Murayama, M., & Goodkind, M. J. (1968) · Circulation Research · doi:10.1161/01.res.23.6.743 · Cited by 35
Sawyer, M. E. M., & Brown, M. G. (1934) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1934.110.3.620 · Cited by 33
Frazer, A., Hess, M. E., & Shanfeld, J. L. (1969) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)28388-4 · Cited by 29
RESPONSE OF THE HYPERTHYROID HEART TO EPINEPHRINE
McDonald, C. H., Shepeard, W. L., Green, M. F., & Degroat, A. F. (1935) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1935.112.2.227 · Cited by 24
CARDIOVASCULAR AND METABOLIC INTERRELATIONSHIPS BETWEEN THYROXINE AND THE SYMPATHETIC NERVOUS SYSTEM
Hess, M. E., & Shanfeld, J. L. (1965) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27050-1 · Cited by 24
INFLUENCE OF THE THYROID HORMONE ON THE EFFECTOR SYSTEMS OF THE MAMMALIAN HEART
Hoffmann, F., Hoffmann, E. J., & Talesnik, J. (1947) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1947.148.3.689 · Cited by 24
THE EFFECT OF THYROXIN, CORTICOSTEROIDS, AND EPINEPHRINE ON ATRIAL RATE
Cravey, G. M., & Gravenstein, J. S. (1965) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27016-1 · Cited by 21
THYROXIN, RESERPINE, EPINEPHRINE AND TEMPERATURE ON ATRIAL RATE
Thier, M. D., Gravenstein, J. S., & Hoffmann, R. G. (1962) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)26272-3 · Cited by 21
Normal Myocardial Adenyl Cyclase Activity in Hyperthyroid Cats
Sobel, B. E., Dempsey, P. J., & Cooper, T. (1969) · Experimental Biology and Medicine · doi:10.3181/00379727-132-34135 · Cited by 20
Total thyroidectomy in angina pectoris
Shambaugh, P., & Cutler, E. C. (1934) · American Heart Journal · doi:10.1016/s0002-8703(34)90375-6 · Cited by 19
EFFECT OF TREATMENT OF HYPOTHYROIDISM ON CIRCULATORY RESPONSE TO ADRENALINE
Leak, D., & Lew, M. (1963) · Heart · doi:10.1136/hrt.25.1.30 · Cited by 17
Benforado, J. M., & Wiggins, L. (1965) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)26952-x · Cited by 16
Benfey, B. G., & Varma, D. R. (1963) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1963.tb01513.x · Cited by 14
EPINEPHRINE TOLERANCE OF THE HEART ALTERED BY THYROXINE AND THIOURACIL
Raab, W. H.-M. (1944) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)08746-4 · Cited by 12
Goodkind, M. J. (1969) · Circulation Research · doi:10.1161/01.res.25.3.237 · Cited by 8
EFFECT OF GUANETHIDINE AND BRETYLIUM ON HEART RATE RESPONSES TO THYROXINE
Barker, S., & Makiuchi, M. (1965) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27015-x · Cited by 7
Klein, I., Levey, G. S., & Epstein, S. E. (1971) · Experimental Biology and Medicine · doi:10.3181/00379727-137-35578 · Cited by 7
Self-citation
Research works printed but not linked: 2
- Goetsch, 1918, Adrenaline hypersensitiveness in clinical states of hyperthyroidism, NY State J Med, 18, 259
- DeGroot, 1961, The importance of autonomic integrity in maintaining the hyperkinetic circulatory dynamics of human hyperthyroidism, J Clin Invest, 40, 1033
Cited by
Sorted by citations
Thyroid hormone and the cardiovascular system
Klein, I. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90531-h · Cited by 370
Cardiovascular and Atherogenic Aspects of Subclinical Hypothyroidism
Kahaly, G. J. (2000) · Thyroid · doi:10.1089/10507250050137743 · Cited by 310
Vascular and renal function in experimental thyroid disorders
Vargas, F., Moreno, J. M., Rodríguez‐Gómez, I., Wangensteen, R., Osuna, A., Álvarez-Guerra, M., & García‐Estañ, J. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02093 · Cited by 285
The clinical pharmacology of beta-adrenoceptor-blocking drugs
CONOLLY, M. E., Kersting, F., & Dollery, C. T. (1976) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(76)90016-5 · Cited by 226
Catecholamine-thyroid hormone interactions and the cardiovascular manifestations of hyperthyroidism
Levey, G. S., & Klein, I. L. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90533-j · Cited by 214
Self-citation
Metadata
- Authors
- Levey, G. S.
- Affiliations
- University of Miami (US)
- Corresponding author
- Levey, Gerald S.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 1971-04
- Volume
- 50
- Issue
- 4
- Pages
- 413-420
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2070055155
- Cited by
- 160
- References
- 55
- Citations by year
- 2024: 2 · 2020: 2 · 2018: 1 · 2016: 1 · 2015: 2 · 2012: 1
- FWCI
- 12.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The American Journal of Medicine (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- catecholamine sensitivity, thyroid hormones, hyperthyroidism, hypothyroidism, inotropic effect, chronotropic effect, adenylate cyclase, hyperdynamic circulation, propranolol, heart rate, cardiac contractility
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review